Effects of Brain Ventricular Shape on Periventricular Biomechanics: A Finite-element Analysis

Peña, Alonso; Bolton, M. D.; Whitehouse, Helen; Pickard, John D.

doi:10.1097/00006123-199907000-00026

Cited by 63 publications

(44 citation statements)

References 27 publications

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“…5,30 Despite the advances reported in these studies, the models used omitted other important geometrical details, such as sulci. Additionally, there has been no attempt to investigate the effect of the degree of ventricular deformation on the biomechanical changes in the brain.…”

Section: Discussionmentioning

confidence: 99%

“…However, a previous FE simulation study suggested that geometrical characteristics may play a major role in PVL in hydrocephalus. 30 In that study, Peña et al found that the distribution of PVL is affected by ventricular geometry, and considered their findings to be evidence supporting the extravasation theory. In contrast, the present study further investigated the effects of the degree of structural deformation, and the results led to opposite conclusions.…”

Section: Influence Of Geometrical Characteristics Of the Hydrocephalimentioning

confidence: 93%

“…FE analysis of the hydrocephalic brain can simulate the main features of hydrocephalus, such as structural deformation, ventricular enlargement, PVL, and cerebral edema; thus, it is widely considered a valid approach to assess biomechanical changes in the hydrocephalic brain. 5,6,9,19,26,30,39,42,43,45 …”

Section: Methodsmentioning

confidence: 99%

“…Previous studies by Peña et al 30 and Cheng and Bilston 5 accurately described the degree and pattern of the stress distribution caused by brain deformation in the hydrocephalic brain using various biomechanical parameters. For the purpose of this study, only the changes in pore pressure were analyzed.…”

Section: Materials Properties and Biomechanical Assessment Of Simulationsmentioning

confidence: 99%

“…15 The relationship between ventricular enlargement and PVL can be investigated via finite element (FE) analysis. 5,30 FE analysis enables the numerical approximation of the mechanical behavior of a structure under stress, by development of a 2D or 3D model that is composed of numerous, yet finite, smaller elements. The method has been increasingly used to assess the biomechanical behavior of the hydrocephalic brain since the pioneering study of Nagashima et al in 1987.…”

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confidence: 99%

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Finite element analysis of periventricular lucency in hydrocephalus: extravasation or transependymal CSF absorption?

Kim¹,

Jeong

Park³

et al. 2016

JNS

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P eriventricular lucency (PVL) refers to the decreased attenuation level, or "blurring," around the periventricular area on CT, or T2 hyperintensity on MRI. This radiological phenomenon is a common finding not only in various neurological or cardiovascular disorders, but also in the general elderly population. 21,22,29,47 Although widely researched and documented, the pathogenesis and clinical significance of PVL are still inconclusive, especially for PVL associated with hydrocephalus. Hydrocephalus is defined as the excessive accumulation of CSF in the brain due to various causes. The disease is considered to be caused by an imbalance between the formation and reabsorption of CSF, due to the disturbance in CSF dynamics. 28 Considering the site of the obstruction in the flow of CSF, two types of hydrocephalus have been defined: communicating and noncommunicating. PVL in hydrocephalus was first documented by Naidich et al. 27PVL and enlarged ventricles are typical radiological signs of acute or noncommunicating hydrocephalus.30 However, these two signs also exist in chronic or communicating hydrocephalus, although the prevalence is relatively lower. 25,34 In either case, the pathogenesis of PVL remains abbreviatioNs FE = finite element; ICP = intracranial pressure; ISF = interstitial fluid; PVL = periventricular lucency; TPG = transmantle pressure gradient. obJective Periventricular lucency (PVL) is often observed in the hydrocephalic brain on CT or MRI. Earlier studies have proposed the extravasation of ventricular CSF into the periventricular white matter or transependymal CSF absorption as possible causes of PVL in hydrocephalus. However, there is insufficient evidence for either theory to be conclusive. methods A finite element (FE) model of the hydrocephalic brain with detailed anatomical geometry was constructed to investigate the possible mechanism of PVL in hydrocephalus. The initiation of hydrocephalus was modeled by applying a transmantle pressure gradient (TPG). The model was exposed to varying TPGs to investigate the effects of different geometrical characteristics on the distribution of PVL. The edema map was derived based on the interstitial pore pressure. results The model simulated the main radiological features of hydrocephalus, i.e., ventriculomegaly and PVL. The degree of PVL, assessed by the pore pressure, was prominent in mild to moderate ventriculomegaly. As the degree of ventriculomegaly exceeded certain values, the pore pressure across the cerebrum became positive, thus inducing the disappearance of PVL. coNclusioNs The results are in accordance with common clinical findings of PVL. The degree of ventriculomegaly significantly influences the development of PVL, but two factors were not linearly correlated. The results are indicative of the transependymal CSF absorption as a possible cause of PVL, but the extravasation theory cannot be formally rejected.

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Section: Discussionmentioning

confidence: 99%

Section: Influence Of Geometrical Characteristics Of the Hydrocephalimentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Materials Properties and Biomechanical Assessment Of Simulationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Finite element analysis of periventricular lucency in hydrocephalus: extravasation or transependymal CSF absorption?

Kim¹,

Jeong

Park³

et al. 2016

JNS

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Neural Tissue Biomechanics: Biomechanics and Models of Structural Neurological Disorders

Cheng

2010

Neural Tissue Biomechanics

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The Influence of Microstructure on Neural Tissue Mechanics

Bilston

2016

Structure-Based Mechanics of Tissues and Organs

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Effects of Brain Ventricular Shape on Periventricular Biomechanics: A Finite-element Analysis

Abstract: The distribution of periventricular edema in acute hydrocephalus is a result not only of increased intraventricular pressure but also of ventricular geometry.

Cited by 63 publications

References 27 publications

Finite element analysis of periventricular lucency in hydrocephalus: extravasation or transependymal CSF absorption?

Finite element analysis of periventricular lucency in hydrocephalus: extravasation or transependymal CSF absorption?

Neural Tissue Biomechanics: Biomechanics and Models of Structural Neurological Disorders

The Influence of Microstructure on Neural Tissue Mechanics

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