Effects of Brain Serotonin Alterations on Hypothermia Produced by Chlorpromazine in Rats

Lin, M.T.; Chern, Y. F.; Chow, Carmen; Li, Y.P.

doi:10.1159/000137241

Cited by 11 publications

(4 citation statements)

References 10 publications

(13 reference statements)

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“…Systemic administration of CPZ to humans and animals has been known to induce hypothermia [9,10,20] and the involvement of serotonin in the CPZ-induced hypothermia has been suggested [25]. On the other hand, injection of CPZ directly into the rostral hypothalamic thermoregu latory centers induces hyperthermia [20,32].…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Hyperthermic Response to Chlorpromazine in the Offspring of Rats Treated with Imipramine

Fujii¹,

Ohtaki²

1985

Dev Pharmacol Ther

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The body temperature in male rats bom to mothers treated with saline or imipramine (5 mg/kg, IMI-F(1)) from day 1 to day 21 of gestation showed a significant decline between 8 and 13 weeks of age. The magnitude of the decline was greater in the IMI-Fi rats than in saline-F, rats. In contrast, the body temperature in the IMI-F, female rats showed a significant rise between 8 and 13 weeks of age. Adult IMI-F(1) male rats showed a significant hyperthermia for 1-2 h after an injection of chlorpromazine while the littermate female rats and the control male and female rats showed a marked hypothermia. The results suggest that prenatal exposure to imipramine induces sex-related alterations in the thermoregulatory centers.

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Section: Discussionmentioning

confidence: 99%

Sex-Related Hyperthermic Response to Chlorpromazine in the Offspring of Rats Treated with Imipramine

Fujii¹,

Ohtaki²

1985

Dev Pharmacol Ther

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“…In the present series of experiments, animals 2-3 weeks after introduction of SN lesions were subjected to experimentation. Both the sham-operated and SNlesioned animals showed no alteration in the basal levels of the mean arterial pressure and heart rate as compared to the untreated controls (CHEN and LIN, 1980;LIN, 1979 ;. On the basis of experimental treatments and histological results, the animals were grouped into one of the following 3 categories : I) sham-lesion controls (n=8) consisting of rats that were surgically manipulated in the same way as experimental groups were treated except that no electrical current was passed, II) rats with acceptable, electrolytic lesions to the SN (n=8) involving substantial or complete loss of pars compacta somata in addition to minimal extra-compacta damage (IAN et al, 1981a), and III) rats with unacceptable, electrolytic lesions to the SN (n=6) producing only minimal or incomplete loss of pars compacta with major extra-compacta damage.…”

Section: Effects Of Electrolytic Destruction Of Substantia Nigra On Rmentioning

confidence: 94%

Activation of dopaminergic receptors within the caudate-putamen complex facilitates reflex bradycardia in the rat.

1982

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The cardiovascular responses to intravenous doses of epinephrine were assessed in sham-operated, substantia nigra (SN)-lesioned, and SN-stimulated rats under urethane anesthesia. Activation of nigrostriatal dopamine pathways with SN stimulation, although showing no alteration in the epinephrine-induced hypertension, did produce a significant enhancement in reflex bradycardia compared to the controls. In contrast, inhibiting nigrostriatal dopamine pathways with SN lesions led to a significant reduction in the epinephrine-induced bradycardia. Furthermore, local injection of a dopamine receptor agonist apomorphine into the caudate-putamen complex (CP) facilitated reflex bradycardia, while intra-CP injection of dopamine antagonists such as haloperidol and pimozide inhibited it. Moreover, the enhancement in the reflex bradycardia induced by intra-CP administration of apomorphine could readily be abolished by pretreatment with intra-CP administration of either haloperidol or pimozide. Therefore, the present data indicate that a dopaminergic synapse occurs within the caudate-putamen complex which mediates reflex bradycardia in the rat. Key Words: dopamine receptor, caudate-putamen complex, reflex bradycardia, substantia nigra. Recent studies of the effects of dopamine (DA) and its agonists in the cardiovascular system have clearly demonstrated the potential of the dopaminergic system in regulating cardiovascular function. For example, dopamine or apomorphine given systemically causes peripheral vasodilatation (GOLDBERG et al., 1977 ; LIN et al., 1979) and reduction of arterial blood pressure (BOLME et al., 1977) which are competitively counteracted by pimozide (a DA receptor blocking agent). After intracisternal injection, apomorphine (a DA receptor-stimulating agent) caused increased arterial pressure in rats (BOLME et al., 1977). In addition, high levels of DA have been found in the carotid bodies of both rats and cats (HANBAUER, 1977; ZAPATA, 1977). However, to our knowledge, little information is available on the role played by the central dopaminergic system in the

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“…CPZ is thought to increase endogenous MEL concentrations by inhibiting the hepatic enzymes that metabolize MEL (Ozaki et al 1976). However, a direct effect of CPZ cannot be ruled out (Lin 1979;Lin et al 1979). In those studies, treatment injections were administered at mid-photophase, when endogenous pineal MEL concentrations are usually low.…”

Section: Role Of Melatonin In Thermoregulationmentioning

confidence: 99%

Melatonin and thermoregulation in ectothermic vertebrates: a review

Lutterschmidt¹,

Lutterschmidt²,

Hutchison³

2003

Can. J. Zool.

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Precise behavioral thermoregulation is well documented in many ectothermic vertebrates. However, many complexities involving the influence of the pineal gland and melatonin (MEL) on thermoregulatory behavior, and thus body temperature (T b ), remain unresolved. Although MEL is commonly considered to decrease T b in both endotherms and ectotherms, several ectothermic species do not modulate T b in response to MEL. Furthermore, it is not yet clear how MEL integrates thermoregulatory behavior with environmental stimuli or how it modulates T b . Some inferences about MEL action in endotherms are not applicable to ectotherms. Changes in ectothermic T b are mediated primarily through behavioral modulation (not physiological modulation as in endotherms). Thus, the most likely mechanism underlying MEL's actions on ectothermic T b is adjustment of the temperature set point in the hypothalamus. We provide a review of the literature addressing the effects of MEL on thermoregulatory behavior in ectothermic vertebrates. We also discuss mechanisms underlying MEL's influence on physiological and behavioral processes in ectotherms and hypotheses regarding interspecific differences in pineal complex and MEL function.Résumé : La thermorégulation comportementale chez les vertébrés ectothermes est un phénomène bien connu. Cependant, des relations complexes concernant l'influence de la glande pinéale et de la mélatonine (MEL) sur le comportement thermorégulateur et, par conséquent, sur la température du corps (T b ), restent à préciser. Bien que MEL soit souvent considérée comme facteur de chute de la température T b , aussi bien chez les endothermes que chez les ectothermes, plusieurs espèces ectothermes ne modifient pas leur température T b en réaction à MEL. De plus, il reste encore à établir comment la mélatonine intègre le comportement thermorégulateur et les stimulus environnementaux et comment elle cause des modulations de la température T b . Certaines conclusions au sujet de l'action de MEL chez les endothermes ne se vérifient pas chez les ectothermes. Les modulations de la température T b chez les ectothernes sont comportementales (pas physiologiques comme chez les endothermes). Le mécanisme qui est le plus susceptible de contrôler l'action de MEL sur la température T b ectothermique consiste donc en un ajustement du réglage de la tempéra-ture dans l'hypothalamus. Nous proposons ici une revue de la littérature sur les effets de MEL sur le comportement themorégulateur des vertébrés ectothermes. Nous examinons les mécanismes qui peuvent être sous-jacents à l'influence qu'exerce MEL sur les processus physiologiques et comportementaux des vertébrés ectothermes et nous discutons des hypothèses expliquant les différences interspécifiques dans le fonctionnement de la glande pinéale et de MEL.[Traduit par la Rédaction] 13 Lutterschmidt et al.

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Effects of Brain Serotonin Alterations on Hypothermia Produced by Chlorpromazine in Rats

Cited by 11 publications

References 10 publications

Sex-Related Hyperthermic Response to Chlorpromazine in the Offspring of Rats Treated with Imipramine

Sex-Related Hyperthermic Response to Chlorpromazine in the Offspring of Rats Treated with Imipramine

Activation of dopaminergic receptors within the caudate-putamen complex facilitates reflex bradycardia in the rat.

Melatonin and thermoregulation in ectothermic vertebrates: a review

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