Effects of brain death on organ quality and transplant outcome

Floerchinger, Bernhard; Oberhuber, Rupert; Tullius, Stefan G.

doi:10.1016/j.trre.2011.10.001

Cited by 98 publications

(74 citation statements)

References 76 publications

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“…Both of these circulatory conditions require pharmacological control of blood pressure, either through administra tion of short halflife antihypertensives in hypertension or through sufficient fluid resuscitation and administra tion of catecholamines in hypotension. 8 Colloidal fluids should be used with care as they can harm renal func tion and accumulate in the hepatic reticuloendothelial system. 9,10 In brain death, failure of neurohypophysal function with consequent central diabetes insipidus requires administration of vasopressin.…”

Section: Pretreatment Measuresmentioning

confidence: 99%

Advances in the management of the explanted donor liver

Nebrig

Pascher

2014

Nat Rev Gastroenterol Hepatol

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Liver transplantation is the best therapy in end-stage liver disease. Donor organ shortage and efforts to expand the donor organ pool are permanent issues given that advances in perioperative management and immunosuppressive therapy have brought the procedure into widespread clinical use. The management of organ procurement, including donor preconditioning and adequate organ storage, has a key role in transplantation. However, the organ procurement process can differ substantially between transplant centres, depending on local and national preferences. Advances in the field have come from experimental and clinical research on dynamic storage systems, such as machine perfusion devices, as an alternative to static cold storage. Determination of the clinical significance of these new systems is a topic worthy of future investigations.

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Section: Pretreatment Measuresmentioning

confidence: 99%

Advances in the management of the explanted donor liver

Nebrig

Pascher

2014

Nat Rev Gastroenterol Hepatol

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“…Consequently, a cascade of inflammatory events is unleashed, leading to exacerbation of ischemia/reperfusion injury and an impaired graft survival. 25 To identify biomarkers for DBD transplant recipients, a study was performed by Welberry Smith et al 9 Their findings revealed that serum aminoacylase-1 (ACY-1) levels at day 1 or 3 post-transplant were significantly associated with delayed, slow, and immediate graft function, particularly dialysis-free survival, by using proteomic analysis of long-term follow-up of 54 renal transplant patients. 9 Furthermore, an independent confirmative cohort study was employed among 194 patients to validate the association between serum ACY-1 level and incidence of DGF.…”

Section: Biomarkers For Nonliving Donor Kidneysmentioning

confidence: 99%

Biomarkers for renal transplantation: where are we?

Dai

Gong³

2013

IJNRD

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Although surgical techniques, post-transplant care medicine, and immunosuppressants have been greatly improved, permanent acceptance of renal allograft remains a clinical challenge owing to the appearance of various influencing factors. To predict graft dysfunction, development of noninvasive biomarkers is becoming a highlighted research topic in the field of renal transplantation, which provides a possibility for physicians to give preemptive rescue treatment. From the viewpoint of diagnostic techniques, repetitive sampling is prerequisite to identify applicable biomarkers in the clinic. Early biomarkers can be used to dynamically monitor renal graft status and accurately predict transplant outcome independent of various confounders. This review highlights recent studies on the predictive value of biomarkers and methods to quantify biomarkers for monitoring kidney transplant. It is important to analyze and compare different biomarkers for living, and nonliving donors. Analysis of identified clinically relevant biomarkers will advance our understanding of distinct molecular and cellular mechanisms of transplantation and provide insight into developing novel potential approaches to induce transplant tolerance.

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“…While advances in tissue-type matching and immunosuppressive protocols have greatly reduced short-term graft dysfunction after renal transplantation, long-term graft function continues to be problematic, especially in patients receiving deceased donor kidneys [1][2][3]. The kidneys of deceased donors are routinely flushed and stored in cold storage (CS) solutions [4].…”

Section: Introductionmentioning

confidence: 99%

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation

Shrum

Parajuli

2016

J Kidney

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Long-term renal function is compromised in patients receiving deceased donor kidneys which require cold storage exposure prior to transplantation. It is well established that extended cold storage induces renal damage and several labs, including our own, have demonstrated renal mitochondrial damage after cold storage alone. However, to our knowledge, few studies have assessed renal and mitochondrial function after transplantation of rat kidneys exposed to short-term (4 hr) cold storage compared to transplant without cold storage (autotransplantation). Our data reveal that cold storage plus transplantation exacerbated renal and mitochondrial dysfunction when compared to autotransplantation alone.Citation: Shrum S, MacMillan-Crow LA, Parajuli N (2016) Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation.

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Effects of brain death on organ quality and transplant outcome

Cited by 98 publications

References 76 publications

Advances in the management of the explanted donor liver

Advances in the management of the explanted donor liver

Biomarkers for renal transplantation: where are we?

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation

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