Effects of botulinum toxin in patients with myofascial pain related to temporomandibular joint disorders: A systematic review

Herrada, Rosa Marina Ramos; Arriola-Guillén, Luis Ernesto; Atoche-Socola, Katherine Joselyn; Bellini-Pereira, Silvio Augusto; Castillo, Aron Aliaga–Del

doi:10.17219/dmp/145759

Cited by 21 publications

(24 citation statements)

References 43 publications

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“…Biofeedback was performed by placing surface electrodes on the skin to measure the frequency, intensity and duration of muscle contractions in order to decrease the tension of cramped muscles or increase the activity of weak muscles [ 17 ]. Meanwhile, botulinum toxin mainly inhibited the release of inflammatory transmitters from sensory nerve endings, while it could achieve flaccidity by inhibiting the release of acetylcholine from nerve endings [ 18 ]. Platelet rich plasma (PRP) was obtained by centrifugation of autologous blood.…”

Section: Discussionmentioning

confidence: 99%

Short-term effects of Kinesio taping combined with cervical muscles multi-angle isometric training in patients with cervical spondylosis

Xiong

Zhang

Zhang³

et al. 2023

BMC Musculoskelet Disord

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Objective The purpose of this study was to investigate the efficacy of Kinesio taping (KT) combined with multi-angle isometric resistance training for cervical spondylosis. Methods Sixty-one patients were divided into two groups by random number table method. Both groups were given multi-angle isometric training, the patients in the observation group were supplemented with Kinesio taping. Before and after treatment, the symptoms of cervical spine function were evaluated in two groups by visual analogue scale (VAS), cervical dysfunction index (NDI), cervical range of motion and muscle stiffness. Results After 3 weeks of treatment, VAS, NDI scores and the cervical range of motion were significantly better than before (P < 0.05). The range of anterior flexion and extension was significantly larger than the control group (P < 0.05), but the range of other motions were not certain. The muscle stiffness in KT group were significantly lower than the control group. Conclusion Kinesio taping combined with multi-angle isometric resistance training can further alleviate the clinical symptoms and correct the neck abnormal posture. But its effects on the range of cervical motion remain uncertain.

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Section: Discussionmentioning

confidence: 99%

Short-term effects of Kinesio taping combined with cervical muscles multi-angle isometric training in patients with cervical spondylosis

Xiong

Zhang

Zhang³

et al. 2023

BMC Musculoskelet Disord

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“…Previously, a few systematic reviews assessed the use of BTX-A therapy for myofascial pain. 5,7,31 One systematic review without meta-analysis reported a reduction in pain intensity in BTX-A groups in three studies, while one study showed no difference in pain compared with placebo. 7 Another review reported that BTX-A was effective in treating refractory myofascial pain.…”

Section: Discussionmentioning

confidence: 99%

“…7 Another review reported that BTX-A was effective in treating refractory myofascial pain. 31 One meta-analysis of four clinical trials on BTX-A versus placebo found that BTX-A was slightly more effective than placebo for pain reduction at 1 month, but showed no difference at 3 and 6 months. 5 Our results align with previous reviews, indicating that BTX-A is effective in improving pain.…”

Section: Discussionmentioning

confidence: 99%

“…One systematic review without meta‐analysis reported a reduction in pain intensity in BTX‐A groups in three studies, while one study showed no difference in pain compared with placebo 7 . Another review reported that BTX‐A was effective in treating refractory myofascial pain 31 . One meta‐analysis of four clinical trials on BTX‐A versus placebo found that BTX‐A was slightly more effective than placebo for pain reduction at 1 month, but showed no difference at 3 and 6 months 5 .…”

Section: Discussionmentioning

confidence: 99%

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Effect of botulinum toxin type A on muscular temporomandibular disorder: A systematic review and meta‐analysis of randomized controlled trials

Li,

Tan,

Yacovelli

et al. 2023

J of Oral Rehabilitation

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BackgroundBotulinum toxin type A (BTX‐A) is increasingly used to manage painful temporomandibular disorders (TMD). However, the effect of BTX‐A on muscular TMD remains unclear.ObjectiveTo assess the efficacy, safety and optimal dose of BTX‐A for treating TMD.MethodsWe conducted systematic literature searches in MEDLINE, Embase, Web of Science, ClinicalTrials.gov and Cochrane Library until March 2023. We extracted data from randomized controlled trials (RCTs) that evaluated the efficacy and safety of BTX‐A in treating muscular TMD. We performed a meta‐analysis using a random‐effects model.ResultsFifteen RCTs involving 504 participants met the inclusion criteria. BTX‐A was significantly more effective than placebo in reducing pain intensity, as measured on a 0–10 scale, at 1 month (MD [95% CI] = −1.92 [−2.87, −0.98], p < .0001) and 6 months (MD [95% CI] −2.08, [−3.19 to −0.98]; p = .0002). A higher dosage of BTX‐A (60–100 U bilaterally) was associated with a greater reduction in pain at 6 months (MD [95% CI] = −2.98 [−3.52, −2.44]; p < .001). BTX‐A also resulted in decreased masseter muscle intensity (μV) (MD [95% CI] = −44.43 [−71.33, −17.53]; p = .001) at 1 month and occlusal force (kg) at 3 months (MD [95% CI] = −30.29 [−48.22 to −12.37]; p = .0009). There was no significant difference in adverse events between BTX‐A and placebo.ConclusionsBTX‐A is a safe and effective treatment for reducing pain and improving temporomandibular muscle and joint function in muscular TMD patients. A bilateral dose of 60–100 U might be an optimal choice for treating muscular TMD pain.

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“…Over the past 30 years, accumulated evidence has established the effectiveness of BoNT-A [ 11 , 15 , 16 , 17 ]. BoNT-A plays also a role in the management of other conditions, such as chronic migraine, focal dystonia, hemifacial spasm, myofascial pain, and cerebral palsy [ 18 , 19 , 20 , 21 ]. Despite the considerable and well-known beneficial effects, many patients suffering from spasticity discontinue treatment.…”

Section: Introductionmentioning

confidence: 99%

Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis

Cinone

Santoro

Spina

et al. 2022

Toxins

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Background: The present study aimed to evaluate the reasons and determinants of BoNT-A discontinuation in patients with stroke, multiple sclerosis, spinal cord injury, and traumatic brain injury. Methods: It is a retrospective study of 56 discontinuer patients treated with botulinum toxin between January 2011 and December 2021. Discontinuation rates and their predictors were estimated using Kaplan–Meier, Log rank test, and Cox’s regression method of analyses.Results: The mean age was 56.54 years, 53.57% were affected by post-stroke spasticity, 17.86% by spinal cord injury, 12.5% and 16.07% by traumatic brain injury and multiple sclerosis, respectively. The median discontinuation time was 5 months. The main reason for discontinuation were logistic problems (37%) and orthopedic surgeries or intrathecal baclofen (27%). Discontinuers were more likely to have severe spasticity (R = 1.785), have no pain (HR = 1.320), no access to rehabilitation services (HR = 1.402), and have cognitive impairment (HR = 1.403). Conclusions: The main reasons for discontinuation are related to logistic issues (due to distance or the absence of an adequate caregiver) and surgical interventions for spasticity, including intrathecal baclofen. It is crucial to identify possible predictors of discontinuation to improve the effectiveness of a multidisciplinary management. The study confirms the crucial role of rehabilitation and caregivers in achieving better long-term outcomes.

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Effects of botulinum toxin in patients with myofascial pain related to temporomandibular joint disorders: A systematic review

Cited by 21 publications

References 43 publications

Short-term effects of Kinesio taping combined with cervical muscles multi-angle isometric training in patients with cervical spondylosis

Short-term effects of Kinesio taping combined with cervical muscles multi-angle isometric training in patients with cervical spondylosis

Effect of botulinum toxin type A on muscular temporomandibular disorder: A systematic review and meta‐analysis of randomized controlled trials

Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis

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