Effects of Botulinum Toxin A on the Contractile Function of Dog Prostate

Lin, Alex T.L.; Yang, An Hang; Chen, Kuang-Kuo

doi:10.1016/j.eururo.2007.03.002

Cited by 61 publications

(42 citation statements)

References 25 publications

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“…The effect persisted for at least 3 months without any notable side effects. Lin et al [14] observed that injection of 200 units of BoNT-A induced atrophic changes in prostate gland and vacuoles formation in smooth muscle cells of stromal tissue and significantly reduced prostate urethral pressure response to norepinephrine and electrostimulation.…”

Section: Prostate Application Of Bontmentioning

confidence: 98%

Ten years single surgeon experience with botulinum toxin in the urinary tract; clinical observations and research discovery

Chancellor

2009

Int Urol Nephrol

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Section: Prostate Application Of Bontmentioning

confidence: 98%

Ten years single surgeon experience with botulinum toxin in the urinary tract; clinical observations and research discovery

Chancellor

2009

Int Urol Nephrol

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“…Lin et al [74] reported that injection with 200 U of onaBoNT-A into the canine prostate significantly reduced the prostate urethral pressure response to i.v. noradrenaline and to electrostimulation [74]. (Table 3).…”

Section: Prostate Bont Applicationmentioning

confidence: 99%

Botulinum toxin for the lower urinary tract

2010

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Botulinum toxins (BoNTs) are known for their ability to potently and selectively modulate neurotransmission for successful long‐term treatment of muscle hypercontractility. Recent studies suggest that BoNT has effects on modulation of sensory processing, inflammation and glandular function. Urologists and urogynaecologists have become interested in the potential application of BoNTs in patients with lower urinary tract symptoms, including detrusor and sphincter overactivity, bladder hypersensitivity, interstitial cystitis/painful bladder symptoms and benign prostatic hyperplasia. We review the biological action of BoNT in bladder and prostate, and present the techniques and results of the clinical studies with BoNT in the lower urinary tract.

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“…Another report speculated that the inhibitory effects on smooth muscle tone by intraprostatic injection of BTX-A may play an important role in the provision of relief for lower urinary tract symptoms [18] . Lin et al [19] also reported that injecting BTX-A into dog prostate reduced contractile function. The apoptotic effects of BTX-A in these tissues thus remain controversial.…”

Section: Discussionmentioning

confidence: 95%

Apoptotic Action of Botulinum Toxin on Detrusor Muscle in Rats

Watanabe

Masago²,

Miyagawa³

2010

Urol Int

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Aims: To examine botulinum toxin A (BTX-A)-induced apoptosis in the detrusor muscle in male rats. Methods: The bladder wall and prostate in adult male Sprague-Dawley rats were injected with BTX-A (10 U at each site). Tissues were harvested after 2 weeks, then the effects of BTX-A on proliferative and apoptotic indices were determined using proliferative cell nuclear antigen and TUNEL staining, respectively. In addition, real-time polymerase chain reaction was used to measure mRNA expressions of the apoptosis-related gene, bcl-2, and BAX in detrusor muscle. Results: Although bladder weight was significantly increased in the BTX-A group compared to controls, no significant changes in prostate weight were identified. While significant increases in proliferative cells were apparent in the vesical mucosa after staining, no significant changes were noted in apoptotic or proliferative cells in detrusor muscle or prostate. In addition, no significant changes between the BTX-A group and controls were seen for mRNA expressions of bcl-2/β-actin or BAX/β-actin in detrusor muscle. Conclusions: The lack of significant changes in cellular dynamics of the detrusor muscle in the current study suggests that BTX-A injection into detrusor muscle for overactive bladder may not induce bladder atrophy.

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Effects of Botulinum Toxin A on the Contractile Function of Dog Prostate

Cited by 61 publications

References 25 publications

Ten years single surgeon experience with botulinum toxin in the urinary tract; clinical observations and research discovery

Ten years single surgeon experience with botulinum toxin in the urinary tract; clinical observations and research discovery

Botulinum toxin for the lower urinary tract

Apoptotic Action of Botulinum Toxin on Detrusor Muscle in Rats

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