Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2

Jamshidi, Zahra; Hashemi, Maryam; Yazdian‐Robati, Rezvan; Etemad, Leila; Salmasi, Zahra; Kesharwani, Prashant

doi:10.1007/s10787-022-01037-4

Cited by 7 publications

(3 citation statements)

References 80 publications

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“…The frankincense BAs mixture possessed potent antiviral activity against Herpes simplex type I virus, and this mixture reduced the number of plaques by 100%, followed by AKBA (75%) (Badria et al., 2003). In another report, B. carteri extract showed significant effects against hepatitis C virus with 90% inhibition at 100 g/mL (Jamshidi et al., 2022). In addition, BAs and B. serrata extracts potently inhibited a wild‐type and a clinical isolate of HSV‐1 by blocking NF‐κB, which is important for viral replication.…”

Section: Antiviral Effectsmentioning

confidence: 95%

Can the golden nutraceutical frankincense combat COVID‐19?

Hussain

2024

Future Postharvest and Food

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Section: Antiviral Effectsmentioning

confidence: 95%

Can the golden nutraceutical frankincense combat COVID‐19?

Hussain

2024

Future Postharvest and Food

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“…The narrative reviews examining other medicinal herbs 14,15,26,28,34 also highlighted anti-inflammatory, antioxidant, antiviral, immune enhancing, immunosuppressive, central nervous system modulating, and immune modulating actions of medicinal herbs. The proposed mechanism of action of medicinal herbs in the treatment of COVID-19 was suggested as being due to the secondary metabolites present in these plants, including sterols, diterpenes, alkaloids, glycosides, and aliphatics.…”

Section: Other Medicinal Herbsmentioning

confidence: 99%

Herbal Medicine and COVID-19: An Umbrella Review

Oakes,

Saunders,

Lloyd

et al. 2023

CANDJ

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Background: Most systems of traditional medicine have been using herbal medicines to prevent and treat acute respiratory conditions and various other conditions for centuries. The aim of this project is to identify and examine the systematic and narrative reviews reporting on the therapeutic use of herbal medicines as it relates to the prevention and treatment of COVID-19 and long COVID. Methods: This paper is part of an umbrella review of studies related to natural health products and natural therapies for the prevention or treatment of COVID-19. It is a follow-up to a live review that was conducted by the World Naturopathic Federation between May 2022 and May 2023. PubMed and Google Scholar were searched for systematic and narrative reviews that met defined quality criteria. Results: Over half of the initial systematic reviews were excluded as they did not meet the inclusion and AMSTAR criteria. The final paper included 25 narrative reviews and 41 systematic reviews (SR), with half of the SRs reporting on the safety of herbal interventions. Various therapeutic properties of over 60 herbal medicines were outlined, some individually and most of them as part of herbal formula (combinations). Conclusion/Summary: Herbal interventions demonstrated statistically significant improved recovery in patients with COVID-19. The most common therapeutic properties identified were immunological properties, anti-inflammatory, anti- microbial, and antioxidant while the most frequently investigated herbs were Glycyrrhiza glabra/uralensis, Tinospora cordifolia, and Curcuma longa. More attention is needed on the regulation of herbal medicines, the quality of research, and the safety of herbal medicines.

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“…1 ) derivatives by applying 2D similarities searching via computational tools and testing by inhibition assay, which is a crucial step of drug discovery. The AKBA is a naturally derived compound from Boswellia serrata and have uses against antiviral and chronic inflammatory diseases of the lung 26 , 27 . The inhibition activity of AKBA is reported for many diseases (Brain, Lungs, and Viral infection) 28 – 31 .…”

Section: Introductionmentioning

confidence: 99%

Identification of new pharmacophore against SARS-CoV-2 spike protein by multi-fold computational and biochemical techniques

Ullah,

Halim

et al. 2024

Sci Rep

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COVID-19 appeared as a highly contagious disease after its outbreak in December 2019 by the virus, named SARS-CoV-2. The threat, which originated in Wuhan, China, swiftly became an international emergency. Among different genomic products, spike protein of virus plays a crucial role in the initiation of the infection by binding to the human lung cells, therefore, SARS-CoV-2’s spike protein is a promising therapeutic target. Using a combination of a structure-based virtual screening and biochemical assay, this study seeks possible therapeutic candidates that specifically target the viral spike protein. A database of ~ 850 naturally derived compounds was screened against SARS-CoV-2 spike protein to find natural inhibitors. Using virtual screening and inhibitory experiments, we identified acetyl 11-keto-boswellic acid (AKBA) as a promising molecule for spike protein, which encouraged us to scan the rest of AKBA derivatives in our in-house database via 2D-similarity searching. Later 19 compounds with > 85% similarity with AKBA were selected and docked with receptor binding domain (RBD) of spike protein. Those hits declared significant interactions at the RBD interface, best possess and excellent drug-likeness and pharmacokinetics properties with high gastrointestinal absorption (GIA) without toxicity and allergenicity. Our in-silico observations were eventually validated by in vitro bioassay, interestingly, 10 compounds (A3, A4, C3, C6A, C6B, C6C, C6E, C6H, C6I, and C6J) displayed significant inhibitory ability with good percent inhibition (range: > 72–90). The compounds C3 (90.00%), C6E (91.00%), C6C (87.20%), and C6D (86.23%) demonstrated excellent anti-SARS CoV-2 spike protein activities. The docking interaction of high percent inhibition of inhibitor compounds C3 and C6E was confirmed by MD Simulation. In the molecular dynamics simulation, we observed the stable dynamics of spike protein inhibitor complexes and the influence of inhibitor binding on the protein’s conformational arrangements. The binding free energy ΔGTOTAL of C3 (−38.0 ± 0.08 kcal/mol) and C6E (−41.98 ± 0.08 kcal/mol) respectively indicate a strong binding affinity to Spike protein active pocket. These findings demonstrate that these molecules particularly inhibit the function of spike protein and, therefore have the potential to be evaluated as drug candidates against SARS-CoV-2.

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Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2

Cited by 7 publications

References 80 publications

Can the golden nutraceutical frankincense combat COVID‐19?

Can the golden nutraceutical frankincense combat COVID‐19?

Herbal Medicine and COVID-19: An Umbrella Review

Identification of new pharmacophore against SARS-CoV-2 spike protein by multi-fold computational and biochemical techniques

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