Effects of bone regeneration materials and tooth movement timing on canine experimental orthodontic treatment

Machibya, Ferdinand Mabula; Zhuang, Yiyuan; Guo, Weizhong; You, Dongdong; Lin, Shujing; Wu, Dong; Chen, Jiang

doi:10.2319/062017-407

Cited by 19 publications

(46 citation statements)

References 14 publications

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“…In this study, similar OTM distance and rate of OTM were observed in control, DBB, and BioCaP group, indicating that both DBB and BioCaP did not obstruct the OTM during 8 weeks. But Machibya et al (2018) reported higher OTM in the DBB group compared to CaP or no graft group. This discrepancy might be caused by the different starting times of orthodontic traction, i.e., at least 1 month after grafting and OTM timing of 6 weeks (Machibya et al, 2018).…”

Section: Discussionmentioning

confidence: 85%

“…But Machibya et al (2018) reported higher OTM in the DBB group compared to CaP or no graft group. This discrepancy might be caused by the different starting times of orthodontic traction, i.e., at least 1 month after grafting and OTM timing of 6 weeks (Machibya et al, 2018). Our results indicate that early orthodontic traction (1 week after grafting) in BioCaP grafted defect enhanced alveolar bone defect healing without hampering OTM.…”

Section: Discussionmentioning

confidence: 85%

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BMP2-Functionalized Biomimetic Calcium Phosphate Graft Promotes Alveolar Defect Healing During Orthodontic Tooth Movement in Beagle Dogs

Jiang

et al. 2020

Front. Bioeng. Biotechnol.

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Background: Grafting of biomaterial in alveolar defect facilitates bone healing and orthodontic treatment. BMP2-functionalized biomimetic calcium phosphate (BioCaP) graft had shown excellent bone defect healing potential in many preclinical studies. In this study, we aimed to investigate the influence of BioCaP graft on surgical alveolar bone defect healing during orthodontic tooth movement (OTM) in beagle dogs.Methods: Nine Beagle dogs were randomly assigned to three groups: control, deproteinized bovine bone (DBB), and BioCaP. The maxillary second premolars were protracted into the defects of the extracted maxillary first premolar for 8 weeks. The rate of OTM, alveolar remodeling and bone defect healing were evaluated by histology, histomorphometry, and cone beam computed tomography (CBCT) imaging. Periodontal probing depth was analyzed. Gingival cervicular fluid was collected at week 4 and 8, and the IL-1β level was measured by ELISA. Results:The histological sections of the bone defect showed more newly formed bone in the BioCaP group. The percentage of new bone formation in the BioCaP group was 1.61-, and 1.25-fold higher compared to the control and DBB group, respectively. After 8 weeks of OTM, the resorption rate of BioCaP was 1.42-fold higher compared to DBB. The root resorption index in the DBB group was 1.87-, and 1.39-fold higher compared to the control and BioCaP group, respectively. CBCT images showed 1.92-, and 1.36-fold higher bone mineral density in the BioCaP group compared to the control and DBB group, respectively. There was no significant difference in OTM among the three groups. The distance between the enamel cementum and the crest of the alveolar ridge in the control group was 1.45-, and 1.69-fold higher compared to DBB and BioCaP group, respectively. Periodontal probing depth at week 8 was reduced in the BioCaP group compared to the control. IL-1β concentration in the gingival cervicular fluid was significantly lower in the BioCaP group compared to the control group at week 4 and 8.Jiang et al. BioCaP Promotes Alveolar Defect HealingConclusion: BioCaP graft robustly promoted bone regeneration and alveolar bone defect healing without affecting OTM. BioCaP graft caused less alveolar bone recession and root resorption of traction tooth with favorable periodontal attachment level indicating that BioCaP as a bioactive and functional bone filling material for alveolar bone defects during orthodontic treatment.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 85%

BMP2-Functionalized Biomimetic Calcium Phosphate Graft Promotes Alveolar Defect Healing During Orthodontic Tooth Movement in Beagle Dogs

Jiang

et al. 2020

Front. Bioeng. Biotechnol.

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“…It should be noted that the method of analysis is crucial to the validity of the conclusion, since results of bone morphometry depend on the VOI. Previous studies selected VOIs either in function of the pressure/tension sides [16] or anatomic sites such as at the furcation [50,51] or mesial root [15] [52] of the rst molar, in different jaws and animal species [53,54] . However, these areas are di cult to be determined accurately.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes in Tooth Displacement and Bone Morphometry in Orthodontic Tooth Movement in Rats: A 3D Analysis

Zong

Dessel

Velde

et al. 2022

Preprint

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This study used a novel 3D analysis to longitudinally evaluate orthodontic tooth movement (OTM) and bone morphometry. Twelve-week-old male Wistar rats were subjected to OTM by applying a constant orthodontic force (OF) of 25cN between one of the upper first molars and a mini-screw. In vivo micro-CTs were taken before and after 10, 17, 24 and 31 days of force application, and superimposed by a novel and rigid voxel-based registration method. Then the tooth and alveolar bone segment at different time points became comparable in the same coordinate system, which facilitated the analysis of their dynamic changes in 3D. By comparison between time points and between OF and no OF sides, this study showed that the OTM rate was not constant through time, but conformed to a ‘V’ shape changing pattern. Besides, OF induced displacement of both loaded and unloaded teeth, and the latter mirrored the former in a delayed manner. In addition, bone morphometric changes synchronized with OTM rate changes, implying that a higher OTM rate was concomitant with more alveolar bone loss. The pressure and tension areas might not be in two opposite sides, but actually adjacent and connected. These findings might provide instructive evidence for both clinical, translational and basic research in orthodontics.

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“…Alveolar bone metabolism is closely related to the speed of orthodontic tooth movement, which results in different bone turnover rates under orthodontic forces based on patient-speci c traits 13,14 . In an experimental study of beagle dogs, the group whose bone density was increased by promoting bone formation exhibited signi cantly reduced tooth movement speed compared to the control group, indicating that the quality of alveolar bone affected orthodontic treatment duration 15 . These individual differences in physiological characteristics stem from respective genetic differences attributed to gene polymorphisms, wherein gene expression levels vary between individuals.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Genetic Polymorphisms on Treatment Duration Following Premolar Extraction

Choi

et al. 2021

Preprint

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To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients were summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified single nucleotide polymorphisms (SNPs) significantly enriched in the two groups via targeted sequencing. Nine SNPs (six genes) were significantly enriched in both groups. In the extreme long group, the frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, the TT genotype of SPP1 (rs1126616), as well as the GG genotype of SFRP2 was significantly higher than in the short group. In the extreme short group, the TC genotype of SPP1, the AA genotype of P2RX7, the CT genotype of TNFSF11, and the AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Accurate prediction of the treatment period through further research will be of great aid to patients as well as orthodontists.

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Effects of bone regeneration materials and tooth movement timing on canine experimental orthodontic treatment

Cited by 19 publications

References 14 publications

BMP2-Functionalized Biomimetic Calcium Phosphate Graft Promotes Alveolar Defect Healing During Orthodontic Tooth Movement in Beagle Dogs

BMP2-Functionalized Biomimetic Calcium Phosphate Graft Promotes Alveolar Defect Healing During Orthodontic Tooth Movement in Beagle Dogs

Dynamic Changes in Tooth Displacement and Bone Morphometry in Orthodontic Tooth Movement in Rats: A 3D Analysis

The Effect of Genetic Polymorphisms on Treatment Duration Following Premolar Extraction

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