Effects of Body Mass Index, Glycemic Control, and Hypoglycemic Drugs on Serum Uric Acid Levels in Type 2 Diabetic Patients

Hussain, Azhar R.; Latiwesh, Omar B; Ali, Farwa; Younis, Mustafa Younis; Alammari, Jamal A.

doi:10.7759/cureus.3158

Cited by 15 publications

(9 citation statements)

References 22 publications

(30 reference statements)

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“…Sodium-glucose co-transporter 2 inhibitor (SGLT-2i) could improve glycemic control and lower SUA levels in T2DM (Hao et al 2018). However, other hypoglycemic drugs, including metformin, rosiglitazone, glibenclamide and pharmacologic insulin, do not have a large impact on SUA concentration (Hussain et al 2018;Iliadis et al 2007;MacFarlane et al 2015). In our study, the T2DM patients were treated with oral hypoglycemic drugs (not including SGLT2i) and insulin.…”

Section: Discussionmentioning

confidence: 79%

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

2019

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Background: Elevated serum uric acid (SUA) has a positive correlation with insulin secretion and insulin resistance indexes. However, whether weight-and gender-specific differences regarding the relationship between SUA within the normal range and β-cell function and insulin resistance exist is unknown in T2DM patients. Methods: Three hundreds and eighty patients with type 2 diabetes were divided into two groups as overweight/obesity (n=268) and normal weight (n=112). Each group were again divided into low (LSUA) and high normal SUA (HSUA). The HbA1c, C-peptide, SUA, creatinine, and lipids profiles were measured. HOMA2IR and HOMA%2B were estimated using fasting glucose and C-peptide by homeostasis model assessment (HOMA). Pearson's correlations and multiple linear regression analyses were conducted to assess the associations between SUA levels and islet function indexes. Results: In overweight/obesity subgroup, the levels of BMI, FCP, P2HCP, FCPI, PPCPI, ΔC-peptide, HOMA2%B and HOMA2IR were higher in HSUA group than in LSUA group. In contrast, the HbA1c, FBS, and P2hBS were lower in HSUA than in LSUA. In normal weight subgroup, there were on differences between the HSUA than LSUA group in terms of clinical characteristics. Pearson's correlations indicated that there were no significant correlations between SUA and insulin secretory capacity in normal weight group, but in overweight/obesity group, SUA had positive significant correlations with P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. In female group, there were no significant correlations between SUA and insulin secretory capacity. However, in male group, SUA had positive significant correlations with insulin secretory capacity include P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. Multiple linear regression showed that SUA was significantly associated with HOMA2%B, but not with HOMA2IR in overweight/obesity and male group. Conclusions : Our study shows that SUA levels within normal range were associated with β-cell function in T2DM patients with overweight/obesity or male. This finding supports that the association between SUA within normal range and insulin secretion ability differs by weight and sex.

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Section: Discussionmentioning

confidence: 79%

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

2019

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show abstract

“…Sodium-glucose co-transporter 2 inhibitor (SGLT-2i) could improve glycemic control and lower SUA levels in T2DM (Hao et al, 2018). However, other hypoglycemic drugs, including metformin, rosiglitazone, glibenclamide, and pharmacologic insulin, do not have a large impact on SUA concentration (Hussain et al, 2018; Iliadis et al, 2007; MacFarlane, Liu & Solomon, 2015). In our study, the T2DM patients were treated with oral hypoglycemic drugs (not including SGLT-2i) and insulin.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender

Zhong¹,

Zhang²,

Yang³

et al. 2019

PeerJ

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Background Elevated serum uric acid (SUA) has a positive correlation with insulin secretion and insulin resistance indexes. However, whether weight- and gender-specific differences regarding the relationship between SUA within the normal range and β-cell function and insulin resistance exist is unknown in type 2 diabetes mellitus (T2DM) patients. Methods A total of 380 patients with type 2 diabetes were divided into two groups as overweight/obesity (n = 268) and normal weight (n = 112). Each group were again divided into low (LSUA) and high normal SUA (HSUA). The HbA1c, C-peptide, SUA, creatinine, and lipids profiles were measured. HOMA2IR and HOMA%2B were estimated using fasting glucose and C-peptide by homeostasis model assessment (HOMA). Pearson’s correlations and multiple linear regression analyses were conducted to assess the associations between SUA levels and islet function indexes. Results In overweight/obesity subgroup, the levels of body mass index, fasting C-peptide (FCP), P2hCP, fasting CPI (FCPI), postprandial CPI (PPCPI), ΔC-peptide, HOMA2%B, and HOMA2IR were higher in HSUA group than in LSUA group. In contrast, the HbA1c, FBS, and P2hBS were lower in HSUA than in LSUA. In normal weight subgroup, there were no differences between the HSUA than LSUA group in terms of clinical characteristics. Pearson’s correlations indicated that there were no significant correlations between SUA and insulin secretory capacity in normal weight group, but in overweight/obesity group, SUA had positive significant correlations with P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. In the female group, there were no significant correlations between SUA and insulin secretory capacity. However, in the male group, SUA had positive significant correlations with insulin secretory capacity include P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. Multiple linear regression showed that SUA was significantly associated with HOMA2%B, but not with HOMA2IR in overweight/obesity and male group. Conclusions Our study shows that SUA levels within normal range were associated with β-cell function in T2DM patients with overweight/obesity or male. This finding supports that the association between SUA within normal range and insulin secretion ability differs by weight and sex.

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“…Its anti-oxidant capacity is much higher than vitamin C and vitamin E 13 . Insulin resistance causes an increase in SUA concentration by both reducing renal uric secretion 14 and accumulating substrates for uric acid production 15 . 16,17 .…”

Section: Quick Response Codementioning

confidence: 99%

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Effects of Body Mass Index, Glycemic Control, and Hypoglycemic Drugs on Serum Uric Acid Levels in Type 2 Diabetic Patients

Cited by 15 publications

References 22 publications

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender

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