Effects of body mass index on IVF outcomes in different age groups

Abstract

Background Herein, we aimed to analyse the effects of body mass index (BMI) on the treatment outcomes of in vitro fertilisation (IVF) in a cohort of women undergoing their first IVF cycle. Methods A total of 2311 cycles from 986 women undergoing their first IVF/intracytoplasmic sperm injection cycle with fresh/frozen embryo transfer between January 2018 and December 2021 at the Center of Reproductive Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, were considered in this retrospective cohort study. First, the included patients were classified into four groups based on their BMI: underweight (BMI < 18.5 kg/m2, 78 patients), normal weight (18.5 ≤ BMI < 24 kg/m2, 721patients), overweight (24 ≤ BMI < 28 kg/m2, 147 patients), and obese (BMI ≥ 28 kg/m2, 40 patients). The IVF outcomes included the Gn medication days; Gn dosage; number of retrieved oocytes, mature oocytes, fertilized oocytes, cleavages, and available embryos and high-quality embryos; implantation rate; clinical pregnancy rate and live birth rate. Next, all the obtained data were segregated into three different subgroups according to the patient age: < 30 years, 30–38 years and > 38 years; the IVF pregnancy outcomes were compared among the groups. Results Compared with the other three groups, the underweight group had a higher number of fertilized oocytes, cleavage and available embryos and a smaller Gn medication days and required a lower Gn dosage. There was no difference in the number of retrieved oocytes and mature oocytes among the groups. Moreover, compared with the women aged 30–38 years in the overweight group, those in the normal weight group had a significantly higher implantation rate, clinical pregnancy rate and live birth rate (p = 0.013 OR 1.75, p = 0.033 OR 1.735, p = 0.020 OR 1.252 respectively). The clinical pregnancy rate was also significantly higher in those aged 30–38 years in the normal weight group than in the obese group (p = 0.036 OR 4.236). Conclusions Although the BMI can greatly affect the pregnancy outcomes of women aged 30–38 years, it has almost no effects on the outcomes of younger or older women.

The effect of female body mass index on cumulative live birth rate in women undergoing in vitro fertilization according to age

“…Being overweight or obese is not only a risk factor for infertility but also significantly reduces the clinical pregnancy rate and increases the risk of miscarriage among assisted reproduction technology patients. [11] In 2020, a large-scale retrospective study found that whether underweight (<18.5 kg/ m 2 ), overweight (24-28 kg/m 2 ) or obese (BMI > 28 kg/m 2 ), the CLBR was significantly lower than that of normal body weight group, especially among younger patients, which is consistent with our findings. [12] In addition, some studies have shown that in the process of IVF/ICSI treatment cycles, people with high BMI usually need more ovarian stimulation drugs, and some studies have found that the decidualization of endometrial stromal cells in obese women is impaired after pregnancy, the growth process of the early placenta is affected, and the rate of early miscarriage increases significantly.…”