Effects of Blood Flow Restriction Therapy for Muscular Strength, Hypertrophy, and Endurance in Healthy and Special Populations: A Systematic Review and Meta-Analysis

Perera, Edward; Zhu, Xi; Horner, Nolan S.; Bedi, Asheesh; Ayeni, Olufemi R.; Khan, Moin

doi:10.1097/jsm.0000000000000991

Cited by 20 publications

(15 citation statements)

References 73 publications

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“…The endurance ratio is an index of muscle endurance response and fatigue resistance. Previous studies have demonstrated that BFR training combined with low-intensity RT can improve muscular endurance in subjects ( Henrique et al, 2019 ; Perera et al, 2022 ). The results of the current study showed that the knee extensor, and elbow flexor endurance ratios in the obese group significantly increased after the experiment in both RT and BFRT groups compared with the pre-experimental group, with the ratio of knee extensor endurance in BFRT group being greater than the ratio in RT group, and the effect of BFR training combined with low-intensity RT in improving muscular endurance in the obese group was superior.…”

Section: Discussionmentioning

confidence: 99%

Effects of blood flow restriction training on muscle fitness and cardiovascular risk of obese college students

Su,

Wang,

Wang

et al. 2024

Front. Physiol.

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Purpose: The aim of this study was to investigate the effect of blood flow restriction (BFR) combined with low-intensity resistance training (RT) on cardiovascular risk factors in obese individuals.Methods: Twenty-six male obese college students were recruited and randomly assigned to a control group (CON, n = 8), a low-intensity RT group (RT, n = 9), and a combined BFR training and low-intensity RT group (BFRT, n = 9).Results: The subjects in BFRT group showed significant reductions in body fat percentage and waist-to-hip ratio and a significant increase in lean mass and muscle mass; the peak torque, peak power, and endurance ratio of knee extensors and elbow flexors were significantly upregulated; the root mean square (RMS) for the medial femoral muscle, lateral femoral muscle and biceps significantly increased; the diastolic blood pressure (DBP) showed a significant decrease. The BFRT group also showed significant up-regulations in RMS of the difference between the adjacent R-R intervals (RMSSD), high-frequency power (HF) of parasympathetic modulatory capacity, the standard deviation of R-R intervals (SDNN) of overall heart rate variability (HRV) changes and low-frequency power (LF) of predominantly sympathetic activity. In addition, glycated hemoglobin (HbA1C), insulin resistance index (HOMA-IR) and fasting blood glucose (FBG) were all significantly downregulated in BFRT group. In parallel, low-density lipoprotein (LDL-C) significantly reduced while high-density lipoprotein (HDL-C) significantly increased in BFRT group.Conclusion: BFR combined with low-intensity RT training effectively improved body composition index, increased muscle mass, improved neuromuscular activation, enhanced muscle strength and endurance, which in turn improved abnormal glucolipid metabolism and enhanced cardiac autonomic regulation.

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Section: Discussionmentioning

confidence: 99%

Effects of blood flow restriction training on muscle fitness and cardiovascular risk of obese college students

Su,

Wang,

Wang

et al. 2024

Front. Physiol.

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“…Comparing low-intensity blood flow restriction training (LI-BFR) with high-intensity resistance training (HIRT), HIRT was more effective in promoting muscle hypertrophy and strength. Nonetheless, LI-BFR surpassed a similar low-intensity protocol, rendering BFR a viable option for individuals unable to manage the high loads associated with HIRT [67].…”

Section: Bfr Exercise Interventions and Outcomesmentioning

confidence: 99%

“…BFR training has potential for faster recovery in post-operative rehabilitation, but the risk of venous thromboembolism is a concern, especially in high-risk patients [67]. Prehabilitation may be a better option for promoting rehabilitation in clinical populations.…”

Section: Use the Bfr In Prehabilitationmentioning

confidence: 99%

Blood Flow Restriction in Oncological Patients: Advantages and Safety Considerations

Vinolo-Gil,

García-Campanario,

Estebanez-Pérez

et al. 2023

Healthcare

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Background: Cancer, being a highly widespread disease on a global scale, has prompted researchers to explore innovative treatment approaches. In this regard, blood flow restriction has emerged as a promising procedure utilized in diverse clinical populations with favorable results including improvements in muscle strength, cardiovascular function, and postoperative recovery. The aim of this systematic review was to assess the efficacy of blood flow restriction in cancer survivors. Methods: An investigation was carried out using various databases until February 2023: PubMed, Scientific Electronic Library Online, Physiotherapy Evidence Database, Scopus, Web of Science, Cochrane Plus, SPORTDiscus, Physiotherapy and Podiatry of the Complutense University of Madrid, ScienceDirect, ProQuest, Research Library, Cumulative Index of Nursing and Allied Literature Complete Journal Storage, and the gray literature. To assess the methodological quality of the studies, the PEDro scale was utilized, and the Cochrane Collaboration tool was employed to evaluate the risk of bias. Results: Five articles found that blood flow restriction was beneficial in improving several factors, including quality of life, physical function, strength, and lean mass, and in reducing postoperative complications and the length of hospital stay. Conclusion: Blood flow restriction can be a viable and effective treatment option. It is important to note that the caution with which one should interpret these results is due to the restricted quantity of articles and significant variation, and future research should concentrate on tailoring the application to individual patients, optimizing load progression, ensuring long-term follow-up, and enhancing the methodological rigor of studies, such as implementing sample blinding.

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“…Further research has shown that the higher metabolic/cardiopulmonary adaptive response of endurance training-BFR seems to be associated with the activation of key genes that drive angiogenesis (vascular endothelial growth factor-VEGF and cytochrome oxidase subunit IV) [19,20]. So far, some relevant studies have reviewed the effects of BFR on aerobic capacity [21][22][23][24][25][26], but there is still a lack of understanding of its application in different populations and the overall understanding of the effects of BFR on endurance. In particular, systematic evaluation on the growth of muscle endurance is rare.…”

Section: Introductionmentioning

confidence: 99%

Effects of Blood Flow Restriction Exercise on Muscle Endurance and Aerobic Capacity in Different Populations: A Systematic Review and Meta-Analysis

Xiong

Wang

Xiang³

et al. 2023

Preprint

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There is a lack of comprehensive understanding of the effect on aerobic capacity and muscle endurance by BFR’s application in different populations. SO the target was to elaborate the influence of BFR training on aerobic capacity and muscle endurance in different populations. A systematic review and meta-analysis were conducted. Literature was retrieved in PubMed, Web of Science, the Cochrane Library databases, Embase, CNKI (China National Knowledge Internet) and CBM (China Biology Medicine). 64 studies met the inclusion criteria, and 19 trials were included in the quantitative analysis. The main results showed that aerobic exercise combined with BFR (AE-BFR) and low-load resistance training with BFR (LBFR-RT) significantly improved athletes' aerobic capacity and muscle endurance, compared with aerobic exercise (AE) and low-load resistance training (LL-RT) (WMD = 2.47, p < 0.01; SMD = 1.15, p < 0.01). However, in the healthy, elderly and patients, no similar significant difference was found. In general, BFR training can significantly improve the muscle endurance and aerobic capacity of athletes. However, it remains to be seen whether the benefits of BFR are greater than non-BFR in the healthy and elderly, the impact of BFR on the patient needs to consider the pathophysiological characteristics of different diseases. The current evidence doesn’t support that anaerobic exercise (ANA-E) or high intensity interval training (HIIT) with BFR brings additional aerobic capacity gains. In addition, some new technological attempts deserve attention.

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Effects of Blood Flow Restriction Therapy for Muscular Strength, Hypertrophy, and Endurance in Healthy and Special Populations: A Systematic Review and Meta-Analysis

Cited by 20 publications

References 73 publications

Effects of blood flow restriction training on muscle fitness and cardiovascular risk of obese college students

Effects of blood flow restriction training on muscle fitness and cardiovascular risk of obese college students

Blood Flow Restriction in Oncological Patients: Advantages and Safety Considerations

Effects of Blood Flow Restriction Exercise on Muscle Endurance and Aerobic Capacity in Different Populations: A Systematic Review and Meta-Analysis

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