Effects of blackberry (Morus nigra L.) consumption on serum concentration of lipoproteins, apo A-I, apo B, and high-sensitivity-C-reactive protein and blood pressure in dyslipidemic patients

Abstract

Background:This study investigated blackberry (Persian mulberry) effects on apo A-I, apo B, high-sensitivity-C-reactive protein (hs-CRP), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in dyslipidemic patients.Materials and Methods:In this 8-week randomized clinical trial, 72 dyslipidemic patients were randomly divided into two groups: Intervention (300 mL/day blackberry juice with pulp) and control group (usual diets). Before and after the intervention, fasting blood samples were taken from both groups and serum concentration of lipoprotein, apo A-I and apo B, serum lipids (total cholesterol, low-density lipoprotein, high-density lipoprotein [HDL], and triglyceride), hs-CRP were measured. Blood pressure before and after the study was measured with a mercury manometer.Results:At week 8 in the intervention group, apo A-I and HDL increased significantly (P = 0.015, P = 0.001, respectively), apo B and hs-CRP decreased significantly (P = 0.044, P = 0.04, respectively). Mean changes in apo A-I and HDL and apo B/apo A-I ratio were significant between the groups (P = 0.005, P = 0.014, and P = 0.009, respectively). After 8 weeks, there was a significant difference between hs-CRP mean values (P = 0.01) of the groups. At week 8, SBP decreased significantly (P = 0.005) in the intervention group with no significant differences for SBP mean values between the groups. No significant changes were observed in other lipid parameters and DBP in the intervention group and between the groups.Conclusion:Blackberry consumption may exert beneficial effects on apolipoproteins, blood pressure, and inflammatory markers in individuals with lipid disorders.

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

“…[ 291 ]. Pulpy blackberry juice consumption by dyslipidemic patients decreased ApoB and hs-CRP, increased ApoA-1 and HDL-C, and left other lipid parameters unaffected [ 134 ]. In healthy subjects, blackberry juice increased exogenous and endogenous antioxidant enzymes.…”

Dietary Strategies by Foods with Antioxidant Effect on Nutritional Management of Dyslipidemias: A Systematic Review

“…The studies included both men and women, except for Jalali-Khanabadi et al [ 20 ] which only included men. The metabolic conditions of subjects included in the studies were moderate hypercholesterolemia [ 21 , 22 ], mildly dyslipidemia [ 23 ], hyperlipidemia [ 20 ], hypercholesterolemia [ 24 , 25 , 26 , 27 ], hiperlipidemia [ 28 ], dyslipidemia [ 29 ], mildly hypercholesterolemia [ 30 , 31 ], dyslipidemia with hypertension [ 32 , 33 , 34 ], and healthy subjects as a control group [ 25 , 27 ]. The studies designs included seven randomized trial [ 26 , 28 , 29 , 30 , 31 , 34 ], six with randomized crossover trial [ 21 , 23 , 25 , 27 , 33 ], and three evaluation of baseline and post intervention [ 20 , 24 ].…”

“…The metabolic conditions of subjects included in the studies were moderate hypercholesterolemia [ 21 , 22 ], mildly dyslipidemia [ 23 ], hyperlipidemia [ 20 ], hypercholesterolemia [ 24 , 25 , 26 , 27 ], hiperlipidemia [ 28 ], dyslipidemia [ 29 ], mildly hypercholesterolemia [ 30 , 31 ], dyslipidemia with hypertension [ 32 , 33 , 34 ], and healthy subjects as a control group [ 25 , 27 ]. The studies designs included seven randomized trial [ 26 , 28 , 29 , 30 , 31 , 34 ], six with randomized crossover trial [ 21 , 23 , 25 , 27 , 33 ], and three evaluation of baseline and post intervention [ 20 , 24 ]. The studies were conducted in Brazil [ 29 , 32 , 33 , 35 ], Iran [ 20 , 26 , 28 , 34 ], Spain [ 21 , 27 ], China [ 24 , 31 ], Korea [ 30 ], Greece [ 25 ], United Stated of America [ 22 ], and Italy [...…”

“…The studies designs included seven randomized trial [ 26 , 28 , 29 , 30 , 31 , 34 ], six with randomized crossover trial [ 21 , 23 , 25 , 27 , 33 ], and three evaluation of baseline and post intervention [ 20 , 24 ]. The studies were conducted in Brazil [ 29 , 32 , 33 , 35 ], Iran [ 20 , 26 , 28 , 34 ], Spain [ 21 , 27 ], China [ 24 , 31 ], Korea [ 30 ], Greece [ 25 ], United Stated of America [ 22 ], and Italy [ 23 ]. Six studies were interventions coupled with washout period or diet standardization [ 21 , 22 , 23 , 27 , 32 , 33 ].…”

“…Different fruits, vegetables, and nuts are a source of antioxidants that can reduce the risk of oxidative-related diseases. The included studies based their interventions on foods such as raw almonds [ 20 ], walnuts [ 21 , 22 ], olive oil [ 23 ], Graptopetalum paraguayense [ 24 ], red wine [ 25 ], grapes [ 26 ], coffee [ 27 ], white sesame seeds [ 28 ], mate tea [ 29 ], wolfberry fruit [ 30 ], and fermented beverage made from fruits and vegetables [ 31 ], Brazil nut flour [ 32 ], granulated Brazil nut [ 33 ], orange juice and blackberry juice [ 34 ], which have been described as the most antioxidant-rich foods [ 36 ]. Due to the chemical composition of the foods included in the studies, the main effects observed were in antioxidant activity, oxidative and inflammatory markers, and on the blood lipids ( Table 2 ).…”