Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice

Abstract

Black tea, a traditional drink, can induce urination and quench thirst. Black brick tea with fungal growth, prepared by steaming, pressing, inducing fungal growth, and drying the black tea, is a new type of black tea with different sensory qualities and is suitable for storage. However, the effects of black brick tea with fungal growth on lowering uric acid are still unexplored. Therefore, the potassium oxonate was administered for 7 consecutive days to establish the hyperuricemic mice. Then allopurinol, black tea,

Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury

“…Accumulating evidence has suggested that natural compounds could downregulate the XO and ADA activities to mitigate the UA formation, such as astaxanthin, konjac glucomannan, and black tea with fungal growth (60)(61)(62). However, the changes in the activities of other UA synthesis-related enzymes induced by natural substances are poorly investigated.…”

Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates

“…Likewise, Li et al [14] reported that EGCG significantly promoted the expression of OAT1 and downregulated the expression of GLUT9 in renal tissues of hyperuricemia rats. At the same time, tea extract significantly lowers serum urate levels through the inhibition of XOD and ADA to produce uric acid [38]. Moreover, interventions using tea extract revealed that tea components upregulate the expression of the intestinal ABCG2 protein and alleviated hyperuricemia by modulating the gut microbiota.…”

“…Antioxidation Protect against metal-induced oxidation by chelating metal ions Cell sulfur metabolism [34] ROS scavenging including superoxide anion and hydroxyl radicals [35,36] Uric acid metabolism Inhibitory activity on xanthine oxidase (XOD) and adenosine deaminase (ADA) enzymes [14,37] Upregulation of uric acid secretion transporters and downregulating uric acid reabsorption [14,38] Glucose metabolism Inhibition of α-glucosidase, an enzyme that hydrolyzes disaccharide and oligosaccharides Increase glucagon-like peptide-1 for lowering blood glucose and improving glucose homeostasis [39,40] Insulin sensitivity…”

Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components

“…There are many studies on tea to lower UA, but we can conclude that the gallic acid, polyphenols and theaflavins contained in tea mainly play the role of inhibiting XOD enzyme activity and lowering UA. The mechanisms involved are simply the down-regulation of the expression of genes involved in uric acid reabsorption, such as GLUT9 and URAT1, and the up-regulation of the expression of genes involved in uric acid transport or excretion, such as ABCG2, OAT1, and OAT3, the inhibition of XOD enzyme activity, and also the anti-HUA effect through the modulation of the inflammatory response or gut microbes (44)(45)(46).…”