Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review

Heshmati, Javad; Namazi, Nazli

doi:10.1016/j.ctim.2015.01.013

Cited by 88 publications

(55 citation statements)

References 26 publications

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“…In spite of considerable efforts for improving chemical drugs, because of some side effects, there is high tendency to use botanical drugs worldwide. So World Health Organization (WHO) encourages researchers to study efficacy and side effects of medicinal herbs in treatment of DM (Heshmati & Namazi, ). Current evidence suggested beneficial effects of herbs for controlling glucose level in diabetes models (Cicero & Colletti, ; Heshmati & Namazi, ; Patti et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials

Askari

Rouhani

Ghaedi

et al. 2019

Phytotherapy Research

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This study was aimed to quantify the antihyperglycemic effect of Nigella sativa (N. sativa). An in‐depth search to identify clinical trials investigating the impact of N. sativa on glycemic indices via MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, and Google scholar databases were performed up to November 2018. We used a random effects model to estimate pooled effect size of fasting plasma glucose (FPG), postprandial blood glucose (PPBG), and hemoglobin A1c (HbA1c). A total of 17 randomized controlled trials investigating the effects of N. sativa on FPG, PPBG, and HbA1c were included. Meta‐analysis suggested a significant association between N. sativa supplementation and reduction in FPG (weighted mean difference [WMD]: −9.93 mg/dl, 95% CI [−13.44, −6.41]), PPBG (WMD: −14.79 mg/dl, 95% CI [−24.19, −5.39]), and HbA1c (WMD: −0.57%, 95% CI [−0.77, −0.37]). Subgroup analysis revealed that N. sativa oil was more effective than N. sativa powder in reduction of FPG. To sum up, N. sativa consumption has a significant lowering effect on glycemic status. Further studies with prolonged durations and powerful design are needed to specify the exact mechanism, optimal dosage, and duration of N. sativa supplementation to obtain a beneficial effect on glycemic status.

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Section: Introductionmentioning

confidence: 99%

Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials

Askari

Rouhani

Ghaedi

et al. 2019

Phytotherapy Research

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“…Evidence from animal studies and human trials have indicated that these spices modulate hyperglycemia and lipid profile function. Their antioxidant characteristics 13 and effects on insulin secretion, glucose absorption, and gluconeogenesis make them potent candidates towards treating diabetes [32,33]. Similarly, the anti-diabetic property of ginkgo (Ginkgo Biloba) may be linked to the ability of its extract to reduce insulin resistance.…”

Section: Culinary Recommendationsmentioning

confidence: 99%

Data-driven analysis of biomedical literature suggests broad-spectrum benevolence of culinary herbs and spices

Rakhi

Tuwani

Mukherjee

et al. 2018

Preprint

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in ¶ These authors contributed equally to this work. AbstractSpices and herbs are key dietary ingredients used across cultures worldwide. Beyond their use as flavoring and coloring agents, the popularity of these aromatic plant products in culinary preparations has been attributed to their antimicrobial properties. Last few decades have witnessed an exponential growth of biomedical literature investigating the impact of spices and herbs on health, presenting an opportunity to mine for patterns from empirical evidence. Systematic investigation of empirical evidence to enumerate the health consequences of culinary herbs and spices can provide valuable insights into their therapeutic utility. We implemented a text mining protocol to assess the health impact of spices by assimilating, both, their positive and negative effects. We conclude that spices show broad-spectrum benevolence across a range of disease categories in contrast to negative effects that are comparatively narrow-spectrum. We also implement a strategy for disease-specific culinary recommendations of spices based on their therapeutic tradeoff against adverse effects. Further by integrating spice-phytochemical-disease associations, we identify bioactive spice phytochemicals potentially involved in their therapeutic effects. Our study provides a systems perspective on health effects of culinary spices and herbs with applications for dietary recommendations as well as identification of phytochemicals potentially involved in underlying molecular mechanisms. 2 Author SummarySpices and herbs are among the important ingredients in culinary preparations whose evolutionary utility is debatable. While their proximate function could be largely due to their flavor, the ultimate reason for their widespread incorporation in traditional recipes is hitherto not well understood. We implemented a computational framework for integrating spice-disease associations compiled from biomedical literature and evidence linking spice phytochemicals with diseases. By mining these tripartite data we highlight broad-spectrum therapeutic effects of spices to provide informed culinary recommendations against disease categories and seek for their potential molecular mechanisms. Through data-driven investigations, our study thus provides evidence-based applications of spices from culinary as well as medicinal perspectives.

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“…NS has also been reported to show some advantages in insulin resistance syndrome and dislipidemic patients. Furthermore, an insulin-sensitization action via enhancing ACC phosphorylation (mainly MAPK signaling pathway) and muscle GLUT4 content as well as progressive normalization of glycaemia are also seen in NA-treated diabetic Meriones shawi [2,7]. In a study, the lipid (4%) and volatile oil fractions (3%) of NS in streptozotocin-induced diabetes mellitus (DM) rats reduced toxicological and adverse consequences significantly [18].…”

Section: Ns In Diabetesmentioning

confidence: 99%

“…[19] NS seed oil and its components -Anti-diabetes mellitus effect. [7] Aqueous extract 0.25 g/kg in mice for 30 days Potent reducing capacity of APAP-induced hepatotoxicity and antioxidant activity.…”

Section: -400 Mg/kg (Po) In Rats For 8 Weeksmentioning

confidence: 99%

“…To date (March 2016) in the databases such as PubMed/Medline, Science Direct, Web of Science, Scopus, and google, a total of 1290 published evidences were found on the following topics: morphology of the plant, isolated compounds and their derivatives, and pharmacological activities. One general revision of this plant was done by Ahmad et al [2], following to a dermatological revision by Aljabre et al [3], an immunomodulatory and anti-inflammatory revision by Majdalawieh and Fayyad [4], an anti-inflammatory, antioxidant, an immunomodulatory [5], male fertility [6], metabolic parameters in diabetes mellitus [7], and thymoquinone and its therapeutic potentials by Darakhshan et al [8]. This review summarizes the above mentioned studies.…”

Section: Introductionmentioning

confidence: 99%

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A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Islam¹

2016

Adv. Biomed. Pharma.

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Nigella sativa L. (NS) has a number of important biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anti-viral, anti-parasitic and anti-protozoal, cytotoxic, anticancer, neuro-, gastro-, cardio-, hetapto-and nephroprotective activities. In addition, the NS exerts beneficiary effects on reproductive, pulmonary and immune systems as well as in diabetes mellitus (DM), fertility (male and female), breast cancer, dermatological complications, dehydration, dyspepsia, and osmotic balance and so on. Among the isolated constituents, thymoquinone (TQ) is a vastly studied phytochemical in NS. A number of reports suggest that, the NS may be one of the potential herbs in health promotion. This review paper will discuss the detailed and mechanistic aspects of the biological activity of N. sativa along with the reported phytoconstituents.

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Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review

Cited by 88 publications

References 26 publications

Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials

Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials

Data-driven analysis of biomedical literature suggests broad-spectrum benevolence of culinary herbs and spices

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

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