Effects of Black Rice Containing Anthocyanins on Plasma and Hepatic Parameters in Type 2 Diabetic &lt;i&gt;db/db&lt;/i&gt; Mice

Watanabe, Mitsuru

doi:10.3136/fstr.22.719

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…(2013) found that black rice bran extracts significantly protected liver cells from damage and experiments in vitro showed that anthocyanin was the main active component in liver protection. Watanabe (2016) found that anthocyanin extract promoted mouse bile acid metabolism, improved lipid metabolism, and inhibited oxidative stress in the body.…”

Section: Introductionmentioning

confidence: 99%

Effects of sorghum rice and black rice on genes associated with cholesterol metabolism in hypercholesterolemic mice liver and intestine

Liu

Huang

Pei

2020

Food Science & Nutrition

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The effects of different proportions of dietary sorghum rice and black rice on the expression of genes related to cholesterol metabolism in mice liver, intestine, and the characteristics of the small intestinal microbiota were investigated. Six types of diets were used to feed C57BL/6 mice: AIN‐93M standard diet, high‐cholesterol model diet, high‐cholesterol and low‐dose sorghum grain or black rice diet, and high‐cholesterol and high‐dose sorghum grain or black rice diet. The results showed that black rice or sorghum grain diets had no effect on the serum TC, LDL‐C levels in the hypercholesterolemic mice, whereas these diets decreased serum TG level, and black rice diets increased serum HDL‐C level. The diets containing black rice and sorghum grain had no effect on liver TC, TG, HDL‐C levels. However, these diets decreased LDL‐C levels significantly except high dose of black rice. The black rice or sorghum grain diets reduced the expression of the genes encoding liver 3‐hydroxyl‐3‐methyl‐glutarate monoacyl coenzyme A reductase (HMG‐CoA‐R) and increased the expression of SREBP‐2, thereby partially inhibiting the synthesis of cholesterol in liver. The diets containing different proportions of black rice and a low proportion of sorghum grain reduced the expression level of Niemann–Pick type C 1 like 1 (NPC1L1) mRNA and increased the mRNA level of the ATP‐binding cassette transporters, ABCG5/ABCG8, in the small intestine, thereby reducing cholesterol absorption. A diet containing a low proportion of black rice promoted the expression of ABCA1 mRNA and increased the expression of high‐density lipoprotein (HDL) mRNA, thereby promoting reverse cholesterol transport. Black rice diets significantly increased the relative abundances of microbiota in the small intestine and maintained biodiversity, while sorghum grain had no positive effect on the abundance of microbiota.

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Section: Introductionmentioning

confidence: 99%

Effects of sorghum rice and black rice on genes associated with cholesterol metabolism in hypercholesterolemic mice liver and intestine

Liu

Huang

Pei

2020

Food Science & Nutrition

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“…Anthocyanins can decrease plasma glucose levels, insulin resistance, and glucose intolerance, and increased plasma insulin secretion has been reported in rats. Oxidative stress was also lower in the control group (Watanabe, 2016). An anthocyanin extract from mulberry fruit at a dose of 125 mg/kg reduced plasma insulin levels in Zucker diabetic fatty (ZDF) rats (Sarikaphuti et al, 2013).…”

Section: Bioactive Compounds In Black Rice Bran Have Potential For Di...mentioning

confidence: 81%

The benefits of black rice bran and the potential of its bioactive compounds as antidiabetic agents

2023

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Prevention strategies for diabetes have been found to minimize the risk of the disease through lifestyle treatments such as physical exercise and nutrition. Plants with strong antioxidant activity have previously been discovered to be effective therapy for Type 2 Diabetes Mellitus. A total of 12 English articles were reviewed. Black rice bran, in its raw extract form, modulate the activity of enzymes, hormones, and molecular signaling related to glucose homeostasis in the body. Black rice bran increases the defense of pancreatic β cells against apoptosis. Bioactive substances in black rice bran such as anthocyanins, proanthocyanidins, γ-oryzanol regulate diabetes-related molecular signaling which ultimately leads to improvement in glucose levels, insulin levels, restoration and protection of pancreatic β cells against apoptosis. These bioactive substances are also possible in suppressing oxidative stress, increasing antioxidant status and decreasing inflammation which is a common condition in diabetes. The conclusion of this literature review was black rice bran has the potential to have an antidiabetic effect through various mechanisms, in which this effect is possible due to the bioactive substances contained in it.

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“…Low GI foods that have been made, for example cupcakes from wheat flour and corn flour sweetened with Stevia rebaudiana (5). An investigation towards making dietary Sohan-Pilaki for people with diabetes and celiac disease by completely swapping out wheat flour for rice-corn flour and replacing sucrose with Stevia-Isomalt (6) Food from konjac and black rice can be an alternative breakfast for people with DMT2 because konjac and black rice have hypoglycemic effect (7), (8). Konjac has a low GI due to its high glucomannan content (9).…”

Section: N I N D O N E S I a T H E I N C I D E N C E O Rmentioning

confidence: 99%

Glycemic index of a breakfast food from black rice, konjac, jack beans, and red dragon fruit in rats with type 2 diabetes

Zhafira,

Dwiyanti,

Aini

2023

IJND

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ABSTRAK Latar Belakang: Penderita DM tipe 2 memerlukan sarapan yang tepat sehingga tidak meningkatkan kadar gula darah, yang harus terbuat dari bahan-bahan dengan indeks glikemik rendah. Beras hitam, porang, kacang koro pedang dan buah naga merah memiliki komposisi bahan dengan indeks glikemik rendah sehingga pengolahannya menjadi sereal sarapan dapat menjadi alternatif yang dapat dikonsumsi penderita DM2 dengan aman.Tujuan: Penelitian bertujuan untuk mempelajari indeks glikemik sereal sarapan beras hitam, porang, kacang koro pedang, dan buah naga merah, dan membandingkannya dengan sereal sarapan yang sudah komersial.Metode: Penelitian ini bersifat eksperimen dengan desain post test. Indeks glikemik dianalisis menggunakan metode incremental area under the blood glucose response curve (IAUC). Data indeks glikemik dianalisis menggunakan uji one way ANOVA yang dilanjutkan dengan uji Duncan.Hasil: Hasil penelitian menunjukkan bahwa sereal sarapan pagi mengandung total gula 13,72%, total serat pangan 33,98%, dan antosianin 35,2%, serta nilai indeks glikemik 49,75. Kadar serat pangan, antosianin pada produk hasil penelitian ini lebih tinggi dibandingkan produk komersial, sedangkan energi lebih rendah. Kesimpulan: Produk sereal sarapan memiliki kandungan serat makanan dan antosianin yang tinggi, serta kandungan gula total dan indeks glikemik yang rendah; dapat digunakan sebagai pengganti sarapan bagi penderita diabetes melitus. Perlu dilakukan penelitian lebih lanjut untuk mengetahui keefektifan produk ini dalam mengontrol glukosa darah puasa pada individu dengan diabetes melitus. KATA KUNCI: antosianin; beras hitam; Indeks Glikemik; sereal sarapan; serat pangan ABSTRACTBackground: Patients with type 2 diabetes need the correct meal that has low glycemic index components in order to prevent blood sugar levels from rising. Due to the low glycemic index of black rice, konjac, jack bean and red dragon fruit, their processing into morning cereals can be a safe choice for DM2 patients.Objectives: The aim of this study was to study the glycemic index of breakfast cereals of black rice, konjac, jack bean, and red dragon fruit, and compare them with commercial breakfast cereals.Methods: This research is experimental with a posttest design. The glycemic index was analyzed using the incremental area under the blood glucose response curve (IAUC) method. Glycemic index data were analyzed using a one-way ANOVA test followed by Duncan's test.Results: The results showed that breakfast cereals contained 13.72% total sugar, 33.98% total dietary fiber, and 35.2% anthocyanins, and a glycemic index value of 49.75. The levels of dietary fiber and anthocyanins in the products of this study were higher than those of commercial products, while the energy levels were lower.Conclusions: Breakfast cereal products have a high content of dietary fiber and anthocyanins, as well as a low total sugar content and glycemic index; can be used as a substitute for breakfast for people with diabetes mellitus. Further research is needed to determine the effectiveness of this product in controlling fasting blood glucose in individuals with diabetes mellitus. KEYWORD: anthocyanin; black rice; Glycemic Index; breakfast cereal; dietary fiber

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Effects of Black Rice Containing Anthocyanins on Plasma and Hepatic Parameters in Type 2 Diabetic <i>db/db</i> Mice

Cited by 7 publications

References 22 publications

Effects of sorghum rice and black rice on genes associated with cholesterol metabolism in hypercholesterolemic mice liver and intestine

Effects of sorghum rice and black rice on genes associated with cholesterol metabolism in hypercholesterolemic mice liver and intestine

The benefits of black rice bran and the potential of its bioactive compounds as antidiabetic agents

Glycemic index of a breakfast food from black rice, konjac, jack beans, and red dragon fruit in rats with type 2 diabetes

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