Effects of black-eyed pea trypsin/chymotrypsin inhibitor on proteolytic activity and on development of Anthonomus grandis

Oligomerization affects the kinetics and thermodynamics of the interaction of a Bowman-Birk inhibitor with proteases

“…It presents rich biotechnological potential as an anticarcinogenic agent, as a guanylin-enhancing natriuresis and renal functional response in rats, as a bradykinin-potentiating molecule, and as an insecticide, inhibiting the growth of larvae with agricultural importance [7][8][9][10][11][12].…”

Effect of trypsin inhibitor from Crotalaria pallida seeds on Callosobruchus maculatus (cowpea weevil) and Ceratitis capitata (fruit fly)

“…The use of proteinaceous inhibitors in insect control strategies has good potential, because insect digestive proteinases are promising targets in the control of various insects, including lepidopterans such as Manduca sexta [3], Heliothis zea [4], Spodoptera litura [5], and Lucilia cuprina [6], and also various coleopterans [7][8][9][10][11]. Despite several suggested physiological functions in plants [12][13][14], the inhibitors are known for their role in response to abiotic [15,16] biotic stresses, especially in plant defense processes against insect pest attack [9,[17][18][19][20].…”

“…Among them, the Kunitz trypsin inhibitor super family [23] has gained particular attention for its specific activity against trypsin-like serine proteinases, with no inhibition of other proteinase classes [24]. Furthermore, Kunitz trypsin inhibitors were capable of inhibiting the proteolytic activity of several lepidopterans, such as the black cutworm (Agrotis ipsilon), corn earworm (H. zea), tobacco budworm (Heliothis virescens), Western spruce budworm (Choristoneura occidentalis) [25] and coleopterans such as the cotton boll weevil (A. grandis) [10]. Several plants have been screened in order to isolate and characterize such proteinase inhibitors, among them the species Crotalaria pallida, which belongs to the Fabaceae family (Sub-family Faboideae), the members of which are herbs, shrubs and trees found in both temperate and tropical areas.…”

Trypsin Inhibitory Activity of Water Extracts from Ecklonia cava as Affected by Temperature and pH

“…그 중 trypsin inhibitor가 광범위하게 연구되어 왔 으며(2), trypsin inhibitor는 식물체에서는 곤충 및 해충의 공격에 대응하는 방어체로서 중요한 역할을 하고 (3)(4)(5)(6), 혈액 응고, 혈소판응집, 항발암성 (7,8) …”