Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells

Feng, Yixing; Jiao, Zhihao; Shi, Jiachen; Li, Ming; Guo, Qing; Lei, Lei

doi:10.1016/j.chemosphere.2015.12.081

Cited by 122 publications

(65 citation statements)

References 49 publications

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“…Fic, Žegura, Sollner Dolenc, Filipič, and Peterlin Mašič () reported that significant cytotoxicity was not observed at concentrations of up to 100 μmol/L for BPA, BPF and BPS in HepG2 cell lines. Feng et al (Feng et al, ) conducted experiments on human adrenal carcinoma cell line (H295R cells) and observed that after 72 h of exposure, IC 50 values of BPF, BPA, and BPS were 208.0, 103.4, and 159.6 μM, respectively (BPA > BPS > BPF), differing from our present results. Overall, BPA was found to be the most cytotoxic chemical when compared to its two analogues, BPF and BPS.…”

Section: Discussioncontrasting

confidence: 99%

The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study

Köse

Rachidi

Béal

et al. 2019

J of Applied Toxicology

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Bisphenol A (BPA) is a well-known endocrine disruptor and it is widely used mainly in the plastics industry. Due to recent reports on its possible impact on health (particularly on the male reproductive system), bisphenol F (BPF) and bisphenol S (BPS) are now being used as alternatives. In this study, RWPE-1 cells were used as a model to compare cytotoxicity, oxidative stress-causing potential and genotoxicity of these chemicals. In addition, the effects of the bisphenol derivatives were assessed on DNA repair proteins. RWPE-1 cells were incubated with BPA, BPF, and BPS at concentrations of 0-600 μM for 24 h. The inhibitory concentration 20 (IC 20 , concentration that causes 20% of cell viability loss) values for BPA, BPF, and BPS were 45, 65, and 108 μM, respectively. These results indicated that cytotoxicity potentials were ranked as BPA > BPF > BPS. We also found alterations in superoxide dismutase, glutathione peroxidase and glutathione reductase activities, and glutathione and total antioxidant capacity in all bisphenol-exposed groups. In the standard and modified Comet assay, BPS produced significantly higher levels of DNA damage vs the control. DNA repair proteins (OGG1, Ape-1, and MyH) involved in the base excision repair pathway, as well as p53 protein levels were down-regulated in all of the bisphenol-exposed groups. We found that the BPA alternatives were also cytotoxic and genotoxic, and changed the expressions of DNA repair enzymes. Therefore, further studies are needed to assess whether they can be used safely as alternatives to BPA or not.

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Section: Discussioncontrasting

confidence: 99%

The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study

Köse

Rachidi

Béal

et al. 2019

J of Applied Toxicology

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“…Biologically, BPF and BPS are suspected as potential endocrine disruptors since they have similar chemical structure to BPA. 12,17 In vivo and in vitro studies have demonstrated that BPF and BPS have some BPA-like estrogenic activities, such as binding to nuclear estrogen receptors and altering adiponectin production. 12,18 They also have effects on peroxisome proliferator-activated receptor gamma (PPAR) signaling pathway, a main target of obesogens, to increase lipid accumulation and differentiation of preadipocytes into adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study

Liu

Lehmler

Sun

et al. 2017

The Lancet Planetary Health

138

100

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Background Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used to substitute bisphenol A (BPA), a widespread environmental endocrine disruptor and putative obesogen. However, studies on effects of BPF and BPS on obesity in humans are lacking. We examined the associations of BPA, BPF, and BPS exposure with obesity in U.S. adults. Methods We included 1,521 participants aged 20 years or older from a cross-sectional study, the National Health and Nutrition Examination Survey 2013–2014. Urinary BPA, BPF, and BPS concentrations were measured using on-line solid phase extraction coupled to high performance liquid chromatography and tandem mass spectrometry. We used body mass index and waist circumference to define general obesity and abdominal obesity, respectively. We used logistic regression with sample weights to estimate the odds ratios (ORs) of obesity and 95% confidence intervals. Findings Higher BPA, BPF, and BPS concentrations were observed in obese adults than non-obese adults. After adjustment for demographic, socioeconomic, lifestyle factors, and urinary creatinine concentrations, BPA, but not BPF or BPS, was significantly associated with obesity. The OR of general obesity was 1.78 (1.10–2.89) comparing the highest with lowest quartile of BPA, 1.02 (0.70–1.47) for BPF, and 1.22 (0.81–1.83) for BPS. The corresponding OR for abdominal obesity was 1.55 (1.04–2.32) for BPA, 1.05 (0.68–1.63) for BPF, and 1.16 (0.72–1.88) for BPS. Interpretation Whereas there were significant associations of BPA exposure with general and abdominal obesity, BPF or BPS, at current exposure level, was not significantly associated with obesity in U.S. adults. Continued biomonitoring of these bisphenols in populations and further investigations on their health effects in humans are warranted.

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“…With regards to the effects of BPS on progesterone production, a previous study by Feng et al. () reported that BPS altered progesterone secretion, but had no effect on oestradiol production. However, that study was undertaken in the human adrenocortical carcinoma cell line H295R, whereas the current study utilized primary granulosa and theca cells, suggesting that the effects of BPS are cell type‐specific.…”

Section: Discussionmentioning

confidence: 99%

“…With regards to the effects of BPS on progesterone production, a previous study by Feng et al (2016) reported that BPS altered progesterone secretion, but had no effect on oestradiol production. However, F I G U R E 1 Effect of bisphenol S (BPS) on granulosa cell oestradiol (a) and progesterone (b) production and cell viability (c).…”

Section: Campen Et Almentioning

confidence: 99%

The impact of bisphenol S on bovine granulosa and theca cells

Campen

Lavallée

Combelles

2018

Reprod Domestic Animals

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Bisphenol S (BPS) is an endocrine-disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine. Granulosa cell oestradiol production was stimulated when cells were exposed to 100 μM BPS under basal conditions, but there was no effect of BPS when cells were stimulated with follicle-stimulating hormone (FSH). Additionally, there was no effect of BPS on granulosa cell progesterone production or cell viability under basal or FSH-stimulated conditions. BPS did not affect theca cell androstenedione or progesterone production, or theca cell viability under basal or luteinizing hormone-stimulated conditions. This study suggests for the first time that BPS may alter oestradiol production by bovine granulosa cells, albeit at a concentration that is unlikely to be physiologically relevant. Further studies are needed to determine the effects of BPS on the bovine oocyte and on other functions of follicular cells.

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Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells

Cited by 122 publications

References 49 publications

The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study

The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study

Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study

The impact of bisphenol S on bovine granulosa and theca cells

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