Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice

Palombo, Paola; Engi, Sheila A.; Yokoyama, Thaís S.; Bezerra, Andréia Gomes; Curado, Daniela Fernández; Anesio, Augusto; Leão, Rodrigo M.; Santos, Paulo Caleb Júnior de Lima; Cruz, Fábio C.; Galduróz, José Carlos Fernandes

doi:10.1016/j.neulet.2020.135551

Cited by 6 publications

(3 citation statements)

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“…Diphenhydramine, an inverse agonist of the histamine H1 receptor, is effective against allergies and is also a potent anticholinergic agent. Benztropine, a centrally acting anticholinergic/antihistamine agent, is also a selective M1 muscarinic acetylcholine receptor antagonist 8–10 . Parenteral anticholinergics (diphenhydramine HCl, 12.5–50 mg or benztropine mesylate, 0.5–2 mg) are frequently used for prompt treatment of this condition, as reported by previous studies in the literature.…”

Section: Discussionmentioning

confidence: 86%

“…Benztropine, a centrally acting anticholinergic/antihistamine agent, is also a selective M1 muscarinic acetylcholine receptor antagonist. [8][9][10] Parenteral anticholinergics (diphenhydramine HCl, 12.5-50 mg or benztropine mesylate, 0.5-2 mg) are frequently used for prompt treatment of this condition, as reported by previous studies in the literature. There is lack of evidence to support the role of benzodiazepines in the treatment of ALD.…”

Section: Discussionmentioning

confidence: 99%

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Risperidone-Associated Acute Laryngeal Dystonia

Erdoğan

İlhan

2021

J Clin Psychopharmacol

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Risperidone-Associated Acute Laryngeal Dystonia

Erdoğan

İlhan

2021

J Clin Psychopharmacol

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“…The immunohistochemistry protocol was based in previous studies from our group ( Cruz et al, 2014 ; Palombo et al, 2020 ; Felipe et al, 2021 ). About 90min after the beginning of the last operant self-administration session, all mice were anesthetized with Isoflurane (1/1ml – Isoforine, Cristália, Itapira, SP, Brazil) and perfused with 20ml of phosphate-buffered saline (PBS) followed by 60ml of 4% paraformaldehyde.…”

Section: Methodsmentioning

confidence: 99%

Maternal Separation Stress Affects Voluntary Ethanol Intake in a Sex Dependent Manner

et al. 2021

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Maternal separation (MS) stress is a predictive animal model for evaluating the effects of early stress exposure on alcohol use disorders (AUD). The extended amygdala (AMY) is a complex circuit involved in both stress- and ethanol-related responses. We hypothesized that MS stress may increase ethanol consumption in adulthood, as well as augment neuronal activity in extended AMY, in a sex-dependent manner. We aimed to investigate the influence of MS stress on the ethanol consumption of male and female mice, and the involvement of extended amygdala sub-nuclei in this process. The C57BL/6J pups were subjected to 180min of MS, from postnatal day (PND) 1 to 14. The control group was left undisturbed. On PND 45, mice (n=28) in cages were exposed to a bottle containing 20% ethanol (w/v) for 4h during the dark period of the light-dark cycle, for 3weeks. Afterward, mice underwent ethanol self-administration training in operant chambers under fixed ratio (FR) schedule. Then, subjects were tested under 2h sessions of a progressive-ratio (PR) schedule of reinforcement (the last ratio achieved was considered the breaking point), and at the end, a 4h session of FR schedule (binge-intake). An immunohistochemistry assay for Fos protein was performed in Nucleus Accumbens (NAcc), Bed Nucleus of Stria Terminalis (BNST), and AMY. Our results showed that in the third week of training, the female MS group consumed more ethanol than the respective control group. The MS group presented increased breakpoint parameters. Female control group and male MS group were more resistant to bitter quinine taste. Increased Fos-immunoreactive neurons (Fos-IR) were observed in the central nucleus of AMY, but not in NAcc nor BNST in male maternal-separated mice. Maternal separation stress may influence ethanol intake in adulthood, and it is dependent on the sex and reinforcement protocol.

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