2022
DOI: 10.21603/2308-4057-2022-2-544
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Effects of bioactive substances isolated from Siberian medicinal plants on the lifespan of Caenorhabditis elegans

Abstract: Medicinal plants are sources of natural antioxidants. Acting as reducing agents, these substances protect the human body against oxidative stress and slow down the aging process. We aimed to study the effects of bioactive substances isolated from medicinal plants on the lifespan of Caenorhabditis elegans L. used as a model organism. High-performance liquid chromatography was applied to isolate bioactive substances from the extracts of callus, suspension, and root cultures of meadowsweet (Filipendula ulma… Show more

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Cited by 14 publications
(2 citation statements)
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“…Excess free radicals damage valuable biomolecules, i.e., DNA, lipids, and proteins. Such damage contributes to the development of various age-related diseases, such as cancer, Alzheimer’s disease, Parkinson’s disease, diabetes mellitus, and atherosclerosis [ 4 , 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Excess free radicals damage valuable biomolecules, i.e., DNA, lipids, and proteins. Such damage contributes to the development of various age-related diseases, such as cancer, Alzheimer’s disease, Parkinson’s disease, diabetes mellitus, and atherosclerosis [ 4 , 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…In previous studies by the authors, it was established that metabolites isolated from the root culture of Scutellaria baicalensis did not cause death or toxic effects on Caenorhabditis elegans [17]. In this work, rodents are chosen as model organisms, which are more complex and similar to humans [18, 19].…”
Section: Introductionmentioning
confidence: 99%