Effects of bile acids on the humoral immune response A mechanistic approach

Correia, Leonor; Podevin, Philippe; Borderie, Didier; Verthier, Nicole; Montet, Jean-Claude; Feldmann, Gérard; Poupon, Raoul; Weill, Bernard; Calmus, Yvon

doi:10.1016/s0024-3205(01)01321-2

Cited by 14 publications

(12 citation statements)

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“…19,21,30 Although the mechanism(s) of the UDCA effect on the improvement of liver function are still unclear, it has been postulated that UDCA, a less hydrophobic bile acid, displaces the more hydrophobic, potentially toxic bile acids from the membranes, protecting the hepatocytes. 31 Conversely, the immunomodulatory properties [32][33][34] as well as an antiapoptotic effect of UDCA 18 have been indicated. In our study, because the stimulation of proinflammatory cyto- kines did not induce apoptosis, the effect of UDCA was supposedly independent from its antiapoptotic action.…”

Section: Discussionmentioning

confidence: 99%

Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells

et al. 2005

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“…Interestingly, although they have the capacity to activate components of innate immunity, bile acids appear to attenuate humoral immune responses. For example, bile acids have the capability to inhibit proliferation of intraepithelial lymphocytes and to attenuate immunoglobulin production from activated monocytes [49].…”

Section: Bile Acids In Regulation Of the Enteric Nervous And Mucosal mentioning

confidence: 99%

Bile acids in regulation of intestinal physiology

Keating¹,

Keely

2009

Curr Gastroenterol Rep

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In addition to their roles in facilitating lipid digestion and absorption, bile acids are recognized as important regulators of intestinal function. Exposure to bile acids can dramatically influence intestinal transport and barrier properties; in recent years, they have also become appreciated as important factors in regulating cell growth and survival. Indeed, few cells reside within the intestinal mucosa that are not altered to some degree by exposure to bile acids. The past decade saw great advances in the knowledge of how bile acids exert their actions at the cellular and molecular levels. In this review, we summarize the current understanding of the role of bile acids in regulation of intestinal physiology.

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“…We found a significant negative correlation between the number of circulating DN T‐cells and the serum level of total bile acids in PBC patients ( r = −0.480, P < 0.001, Figure A). It has been reported that several serum bile acid levels were elevated in PBC, such as glycochenodeoxycholic acid, glycocholic acid and LCA, and bile salts can inhibit the cytokine production and proliferation of lymphocytes . The rank order for bile acid hydrophobicity is LCA > deoxycholic acid > chenodeoxycholic acid > UDCA .…”

Section: Resultsmentioning

confidence: 99%

Alteration of liver‐infiltrated and peripheral blood double‐negative T‐cells in primary biliary cholangitis

Zhang

et al. 2019

Liver International

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Background & Aims Double‐negative (DN) T‐cell is a unique regulatory T‐cell, which is essential for maintaining immune system homoeostasis. However, the role of DN T‐cells in the pathogenesis of primary biliary cholangitis (PBC) is still unknown. Methods We investigated the number and function of DN T‐cells in peripheral blood and liver biopsy specimens of PBC patients. Results The number and frequency of DN T‐cells significantly decreased in peripheral blood and liver tissue of PBC patients. Furthermore, the frequency of DN T‐cells in PBC was negatively correlated with disease severity and positively correlated with ursodeoxycholic acid response. In vitro assays showed that perforin expression and the suppressive capability of DN T‐cells on the proliferation of CD4+ and CD8+ T‐cells were impaired in PBC. Finally, lithocholic acid, the most hydrophobic acid, could downregulate the proliferation and perforin expression of DN T‐cells. Conclusions Decreased quantity and function of DN T‐cells in PBC may result in the loss of immune regulations on effector CD4+ and cytotoxic CD8+ T‐cells, and thereby may break the immune tolerance and promote the pathogenesis of PBC.

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Effects of bile acids on the humoral immune response A mechanistic approach

Cited by 14 publications

References 0 publications

Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells

Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells

Bile acids in regulation of intestinal physiology

Alteration of liver‐infiltrated and peripheral blood double‐negative T‐cells in primary biliary cholangitis

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