Effects of biguanides on fatty acid and glucose oxidation in muscle

Corsini, G.U.; Sirigu, F; Tagliamonte, P.; Muntoni, Sergio

doi:10.1016/s0031-6989(74)80044-5

Cited by 13 publications

(5 citation statements)

References 8 publications

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“…In vitro and in vivo studies have shown, that metformin can enhance peripheral glucose uptake [26], especially the oxidation of glucose [27] and decrease gluconeogenesis [28]. In addition, metformin can alter the intestinal absorption of glucose [29]. Interestingly, biguanides have also been shown to inhibit NEFA oxidation in rat diaphragm [30].…”

Section: Discussionmentioning

confidence: 99%

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

et al. 1989

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Which therapy should be used in Type 2 (non-insulin-dependent) diabetic patients with "secondary sulfonylurea failure", insulin or a combination of sulfonylurea and metformin? To address this question, we have compared the effect of 6 months of insulin therapy twice daily with that of a combination of glibenclamide and metformin in 24 Type 2 diabetic subjects, who no longer responded to treatment with sulfonylureas. Both treatments resulted in an equivalent 30% improvement in mean daily blood glucose (p less than 0.001), without significant effect on serum lipids. Insulin improved glycaemic control primarily by reducing basal hepatic glucose production (p less than 0.05), but had no significant effect on peripheral glucose metabolism. The combination of glibenclamide and metformin enhanced significantly total body glucose metabolism (p less than 0.05), predominantly by stimulating the non-oxidative pathway. Neither insulin nor the combination therapy altered B-cell response to a test meal. Insulin therapy resulted in a 6% increase in body weight, 63% of which was accounted for by increased fat mass. Although body weight was unchanged during sulfonylurea/metformin therapy, lean body mass and energy expenditure decreased significantly (p less than 0.05). We conclude that insulin and glibenclamide/metformin have different long-term effects on glucose and energy metabolism in Type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

et al. 1989

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“…10 Several mechanisms have been suggested to be responsible for the antihyperglycemic action of phenformin. Among these are decreased glucose absorption from the gut, 11 increased anaerobic glucose metabolism as a consequence of tissue hypoxia, 12 increased glucose metabolism as a consequence of decreased fatty acid oxidation, 13 and enhanced sensitivity of peripheral tissues to circulating insulin. 4 " 7 The observations reported here lend support to this last hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Phenformin Increases Insulin Binding to Human Cultured Breast Cancer Cells

et al. 1980

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The effect of the hypoglycemic biguanide, phenformin, on the binding of insulin to MCF-7 cells, an in vitro line derived from a human breast cancer, has been investigated. Cells incubated for 24 h in the presence of 1.0 micrograms/ml of phenformin bound 62.2 +/- 8.1% (mean +/- SE) more 125I-insulin than did controls. The phenformin effect was dose-dependent over the concentration range of 0.1 micrograms/ml to 10.0 micrograms/ml. The increased binding was due to an increase in receptor number without a change in binding affinity. This demonstration of increased receptor number in response to phenformin exposure provides support for the hypothesis that one action of phenformin is to enhance tissue sensitivity to insulin.

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“…It has been shown that metformin has no effect on insulin secretion, although a certain quantity of endogenous insulin is a prerequisite for the therapeutic effect (1)(2)(3)(4). The antihyperglycemic action of metformin is multifactorial and has been attributed to a diminished, intestinal absorption of carbohydrates (5,6), reduced gluconeogenesis (7)(8)(9), and increased peripheral glucose uptake (10)(11)(12). The mechanism of metformin's effect to reduce peripheral insulin resistance is not understood.…”

Section: Tissue (Glut4) In Adipocyte Membrane Fractions Separated By mentioning

confidence: 99%

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

et al. 1991

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To examine the cellular mechanism of the antihyperglycemic action of metformin, we studied its effect on various functional and molecular parameters involved in the pathogenesis of insulin resistance. Isolated rat adipocytes were incubated with or without metformin (1-100 micrograms/ml) for 2 h at 37 degrees C followed by an incubation with or without insulin (1.72 nM). Metformin treatment had no significant effect on basal 3-O-methylglucose uptake. In contrast, metformin increased insulin-stimulated glucose transport in a dose-dependent manner up to 43 +/- 7%. This effect was neither associated with a significant effect of metformin on trace insulin binding (1.74 +/- 0.20% without metformin vs. 1.89 +/- 0.30% with metformin; P greater than 0.05) nor with an effect of metformin on insulin-receptor kinase activity as measured by 32P incorporation into the 95,000-Mr beta-subunit of the insulin receptor and an exogenous substrate, histone 2B.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effects of biguanides on fatty acid and glucose oxidation in muscle

Cited by 13 publications

References 8 publications

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

Phenformin Increases Insulin Binding to Human Cultured Breast Cancer Cells

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

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