Effects of beta‐glucans ingestion (Saccharomyces cerevisiae) on metabolism of rats receiving high‐fat diet

Abstract

We investigated the effects of beta-glucans (Saccharomyces cerevisiae) ingestion on metabolic parameters of Wistar rats receiving high-fat diet. The experimental period was divided into two stages: in the first one, the animals were divided into two groups containing 12 animals each. The first group received commercial feed and the second received high-fat diet containing 20% of pork fat during 60 days. At the end of this period, body weight, blood glucose and Lee index were assessed. In the second stage, those 24 animals were redivided into four groups: (C) - control diet; (CB) - control diet and treated with Beta-glucan (BG); (O) - obese animals and (OB) - obese animals treated with BG. Animals from groups CB and OB received 30 mg/kg of BG dissolved in saline solution by gavage. Animals from groups C and O received only saline solution for 28 days. The design used was totally randomized in 2 × 2 factorial scheme. Data were submitted to analysis of variance (anova). Animals from OB group showed inferior levels (p < 0.05) of total cholesterol (13.33%), triacylglycerols (16.77%) and blood glucose (23.97%) when compared to the animals from group O. The use of BG has provided smaller increase in Lee index (p < 0.05), without promoting alteration in feed and water consumption, organs weight, HDL-C, LDL+VLDL-C, carcass composition, villus/crypt ratio, and pancreas, kidney and stomach histology. BG from S. cerevisiae promoted beneficial metabolic effects in rats receiving high-fat diet.

Promising Effects of Beta-Glucans on Metabolism and on the Immune Responses: Review Article

“…Complementarily, beta-glucans also decreased blood levels of total cholesterol (13%), triglycerides (17%) and glucose (24%), in obese rats (induced by high fat diet) when compared to untreated obese animals (de Araújo et al, 2016). Reduction of total cholesterol and LDL fraction were also reported elsewhere (Tiwari and Cummins, 2011).…”

Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut dysbiosis

“…Being a major soluble fiber found in the cell walls of oats and barley endosperm, the βglucan is commercially extracted from Saccharomyces cerevisiae and also from other sources such as Phellinus linteus or Sparassis crispa [9,10]. While oat and barley based β-glucan presents metabolic effects such as postprandial glycemic response, fungi derived β-glucan exerts immunological modulation; thereby making the sources of β-glucan as one of the prime factors contributing to its clinical outcome [11,12]. Further, the fermentation of this indigestible fiber in the lower gastrointestinal tract is said to alter the gut microbial composition, whose metabolites is found to have prime importance on host health [13,14].…”

Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)

“…However, even with the benefits observed with beta-glucan consumption or exercise, no changes were found in the degree of steatosis in any treatment. Beta-glucan consumption did not significantly alter steatosis either in a recent study of our group that investigated the effects of these fibers in rats submitted to high-fat diet [18]. On the other hand, it was observed that, in Sprague–Dawley rats, hepatic steatosis was reversed after eight weeks of treadmill exercise associated with restrictive diet (low-fat) [51].…”

“…The Lee index was calculated dividing the cubic root of body weight (grams) by the naso-anal length (cm) [18,28]. Internal organs, skin, head, feet and tail were removed from the animals and the clean carcasses were weighed and processed.…”

“…Cereal beta-glucans are reported to show metabolic potential, while those from fungi and yeast increase immune response [10,14,15]. Although fungi beta-glucans are recognized to modulate the immune response [16], recent studies from our group have also demonstrated interesting metabolic effects of yeast beta-glucans ( Saccharomyces cereviseae ) [10,17,18]. …”