Effects of Bergenin, the Major Constituent of <i>Mallotus japonicus</i> against <i>D</i>-Galactosamine-Induced Hepatotoxicity in Rats

Abstract

The hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, were evaluated against D-galactosamine (GalN)-induced liver damage in rats. Bergenin (50, 100 and 200 mg/kg) was given orally once daily for 7 successive days and then GalN 400 mg/kg was injected intraperitoneally to rats at 24 and 96 h after the final administration of bergenin. Pretreatment with bergenin reduced the increased enzyme activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase, γ-glutamyltransferase and the elevated level of malondialdehyde induced by GalN. Bergenin restored the decreased hepatic contents of glutathione as well as the decreased activities of glutathione S-transferase and glutathione reductase by GalN towards normalization, suggesting that the hepatoprotective effects of bergenin may consist in maintaining adequate levels of hepatic glutathione for the removal of xenobiotics. The present results indicate that bergenin has hepatoprotective effects against GalN-induced hepatotoxicity in rats.

Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex

“…Bergenin has been widely used for the treatment of chronic bronchitis and has other effects such as antitussive, hepatoprotective, anti-infl ammatory, neuroprotective and weak anti-HIV activities [3][4][5][6] . Although bergenin has been used for more than 30 years, its poor oral bioavailability is still an obstacle to its further application [7] .…”

Simultaneous Quantification of Bergenin, (+)-Catechin, Gallicin and Gallic acid; and Quantification of β-Sitosterol using HPTLC from Bergenia ciliata (Haw.) Sternb. Forma ligulata Yeo (Pasanbheda)

“…These five compounds have been shown to have significant pharmacological activities. Bergenin is reported to have hepatoprotective [40], and immunomodulatory [41] activity. (+)-Catechin has been shown to have antioxidant [42], glucosidase-II [43] and matrix metalloproteinase inhibitory activity [44] and renoprotective effect [45].…”

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

“…The most notable biological activity of arbutin is potent inhibition of tyrosinase enzyme that attribuites to its use as a commercial skin lightning agent [74][75][76]. On the other hand, bergenin has numerous biological effects, including antiviral [77], antiulcer [78], antiarethmetic [79], antidiabetic and anti-obesity [80], anti-inflammatory [81], immunomodulatory [82] and hepatoprotective [83][84][85] effects.…”