Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth

Navarra, Michele; Ferlazzo, Nadia; Cirmi, Santa; Trapasso, Elena; Bramantı, Placido; Lombardo, Giovanni Enrico; Minciullo, Paola Lucia; Calapai, Gioacchino; Gangemi, Sebastiano

doi:10.1111/jphp.12403

Cited by 80 publications

(52 citation statements)

References 62 publications

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“…Similarly, total flavonoids from Citrus paradisi Macfadyen peel, when combined with arsenic trioxide, produced a synergistic effect in reducing the proliferation of leukemia cells and triggering apoptosis [249], suggesting that Citrus extracts could be used as co-adjuvants in cancer therapy. Finally, we have shown that the bergamot essential oil (BEO) obtained by rasping the peel of Citrus bergamia fruits decreased the growth rate of SH-SY5Y neuroblastoma cells [250] by a mechanism correlated to both apoptotic and necrotic cell death [251]. Table 5 summarizes the main characteristics of the above investigations into the anti-cancer properties of Citrus juices and extracts.…”

Section: Anti-cancer Properties Of Citrus Juices and Extractsmentioning

confidence: 99%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

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Fruits and vegetables have long been recognized as potentially important in the prevention of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown by increasing number of experimental studies about the relationship between diet and cancer development. This review attempts to provide an insight into the anti-cancer effects of Citrus fruits, with a focus on their bioactive compounds, elucidating the main cellular and molecular mechanisms through which they may protect against cancer. Scientific literature was selected for this review with the aim of collecting the relevant experimental evidence for the anti-cancer effects of Citrus fruits and their flavonoids. The findings discussed in this review strongly support their potential as anti-cancer agents, and may represent a scientific basis to develop nutraceuticals, food supplements, or complementary and alternative drugs in a context of a multi-target pharmacological strategy in the oncology.

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Section: Anti-cancer Properties Of Citrus Juices and Extractsmentioning

confidence: 99%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

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“…Amongst CFs, Citrus bergamia Risso et Poiteau (bergamot) has gained an ever‐increasing attention of the scientific community. It found the most appropriate climate conditions in the southern coasts of the Calabria region (Italy), where it is cultivated primarily for the extraction of the essential oil (BEO) from the peel, exploited mainly in cosmetic industry and in aromatherapy (Mannucci et al, ), as well as studied for its activity as antimicrobial (Cirmi, Bisignano, Mandalari, & Navarra, ) and anti‐proliferative agent (Navarra et al, ). Bergamot juice (BJ) has always been considered a by‐product, yet in the last decade, the beneficial effects of its flavonoid‐rich extract (BJe) have been highlighted by several studies (Cirmi et al, ; Ferlazzo, Cirmi, Calapai, et al, ; Mannucci et al, ).…”

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confidence: 99%

The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

Maugeri

Ferlazzo

Luca

et al. 2019

Phytotherapy Research

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A previous report indicated that the flavonoid‐rich extract of bergamot juice (BJe) exerts an anti‐inflammatory effect through the activation of SIRT1 in leukemic monocytes THP‐1 exposed to lipopolysaccharide (LPS). In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell‐free, in silico, and in vitro experimental models. In the cell‐free assay, all the tested compounds as well as the whole BJe inhibited the deacetylase activity of SIRT1. This finding was reinforced by the results of the in silico study. In THP‐1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre‐incubation with either BJe or its major flavonoids. This effect was also observed at gene level. Employing an activator and an inhibitor of AMP‐activated protein kinase (AMPK; AICAR and dorsomorphin, respectively), we discovered its involvement in the activation of SIRT1 elicited by BJe or its major flavonoids in whole cell. Our study indicates the dual role of BJe and its components, depending on the employed experimental model as well as reveals their mode of action on the AMPK/SIRT1 axis, suggesting their role as promising candidates in pathologies in which this axis is implied.

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“…It is known that natural product can be used to prevent and/or alleviate several health disorders (2-4), including those affecting the urinary tract (5). Moreover, regular dietary habits coupled with a healthy lifestyle may protect against certain types of cancer (6,7), including PCa. In particular, epidemiological studies have shown that Asiatic populations have lower rates of PCa compared to others races and that Asian men who adopt a lifestyle typical of Western countries because of migration to the United States, have a significantly higher risk of PCa when compared to their native Asian counterparts (8).…”

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Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial

Micali

Territo

Pirola

et al. 2017

Arch Ital Urol Androl

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Background and study objective: Several studies suggest a protective role of green tea catechins against prostate cancer (PCa). In order to evaluate the efficacy of green tea catechins for chemoprevention of PCa in patients with high-grade prostate intraepithelial neoplasia (HG-PIN) we performed a phase II clinical trial. Methods: Sixty volunteers with HG-PIN were enrolled to carry out a double-blind randomized placebo-controlled phase II clinical trial. Treated group took daily 600 mg of green tea catechins (Categ Plus ® ) for 1 year. Patients were screened at 6 and 12 months through prostatic biopsy and measurements of prostate-specific antigen (PSA). Results: Despite the statistically significant reduction of PSA observed in subjects who received green tea catechins for 6 and 12 months, we did not find any statistical difference in PCa incidence between the experimental groups neither after 6 nor after 12 months. However, throughout the one-year follow-up we observed very limited adverse effects induced by green tea catechins and a not significant improvement in lower urinary tract symptoms and quality of life. Conclusions: Although the small number of patients enrolled in our study and the relatively short duration of intervention, our findings seems to deny the efficacy of green tea catechins. However, results of our clinical study, mainly for its low statistical strength, suggest that the effectiveness of green tea catechins should be evaluated in both a larger cohort of men and longer trial.

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Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth

Abstract: Our study provides novel insights into the field of the antiproliferative effects of BEO, which could be exploited in the context of a multitarget pharmacological strategy.

Cited by 80 publications

References 62 publications

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial

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