Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

Zverinsky, I.V.; Zverinskaya, H G; Semenenya, I. N.; Telegin, P. G.; Shlyahtun, A. G.

doi:10.18097/pbmc20156103381

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have underscored the critical role that cytochrome P450 (CYP450) may play in the development or treatment of neurological diseases based on its effects on temperature control, maintenance of brain cholesterol homeostasis, neuropeptide release, and regulation of neurotransmitter levels [137]. It has been reported that BBR has a potent regulatory effect on CYP450 activities in liver, heart, kidney, and breast tissues [7,[138][139][140][141][142][143][144][145][146][147].…”

Section: Modulation Of Cyp450 Enzyme Activitiesmentioning

confidence: 99%

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Tian,

Sharma,

Dai

2023

Antioxidants

View full text Add to dashboard Cite

Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis chinensis and other Berberis plants. BBR possesses various bioactivities, including antioxidant, anti-inflammation, anticancer, immune-regulation, and antimicrobial activities. Growing scientific evidence underscores BBR’s substantial neuroprotective potential, prompting increased interest and scrutiny. In this comprehensive review, we elucidate the neuroprotective attributes of BBR, delineate the underlying molecular mechanisms, and assess its clinical safety and efficacy. The multifaceted molecular mechanisms responsible for BBR’s neuroprotection encompass the attenuation of oxidative stress, mitigation of inflammatory responses, inhibition of apoptotic pathways, facilitation of autophagic processes, and modulation of CYP450 enzyme activities, neurotransmitter levels, and gut microbiota composition. Furthermore, BBR engages numerous signaling pathways, including the PI3K/Akt, NF-κB, AMPK, CREB, Nrf2, and MAPK pathways, to confer its neuroprotective effects. This comprehensive review aims to provide a substantial knowledge base, stimulate broader scientific discourse, and facilitate advancements in the application of BBR for neuroprotection.

show abstract

Section: Modulation Of Cyp450 Enzyme Activitiesmentioning

confidence: 99%

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Tian,

Sharma,

Dai

2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Показаны его защитные эффекты при поражениях печени различного генеза. Результаты проведенных нами ранее исследований подтверждают гепатопротекторный потенциал берберина при моделировании холестаза [4] и частичной гепатэктомии [5].…”

unclassified

Evaluation of silymarin and berberine efficiencies in the self-emulsifying drug delivery systemin paracetamol-induced experimental toxic liver injury

et al. 2020

View full text Add to dashboard Cite

The hepatoprotective properties of the silymarin and the plant alkaloid berberine combinationin experimental paracetamol-inducedliver damage were studied. Silymarin was obtained from milk thistle seeds. The conditions for extraction of flavonolignans (silymarin) were optimized. 70 % ethyl alcohol, ethyl acetate and water were used as extractants. It was shown that the optimal conditions for the extraction of flavonolignans in order to obtain the maximum yield of flavonolignans were alcohol extraction in a Soxhlet apparatus. The experiment showed that the combined of silymarin and berberine was greater than their individual actions, which most effectively permitted stabilization of hepatocyte membranes and prevented altering their integrity in paracetamol-induced toxic liver damage. The self-emulsifying system with silymarin and berberine to a greater extent a significant extent prevented dystrophic changes in hepatocytes and necrosis in liver tissue, reduced hyperfermentemia in rat blood serum, prevented disturbance in the activity of thioredoxin reductase and enzymes of the glutathione antioxidant system and there by more effectively prevented hepatocyte functional impairment.

show abstract

Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

Semenenya¹,

Шляхтун²,

Titko³

et al. 2019

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

View full text Add to dashboard Cite

The hepatoprotective effect of the self-emulsifying composition with berberine was studied in the model of toxic liver damage in rats with acetaminophen and its hepatoprotective properties were analyzed in comparison with the use of berberine in free form. The course introduction of self-emulsifying composition with berberine before intoxication of rats with acetaminophen to a greater extent inhibits the development of cytolysis of hepatocytes, and also promotes the enhancement of the glutathione unit of the antioxidant system, increasing the content of total and free sulfhydryl groups, compared with the introduction of free berberine in animals.

show abstract

Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

Cited by 3 publications

References 8 publications

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Evaluation of silymarin and berberine efficiencies in the self-emulsifying drug delivery systemin paracetamol-induced experimental toxic liver injury

Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

Contact Info

Product

Resources

About