Effects of berberine, glaucine, stephaglabrine, and sanguirythrine on neuromuscular transmission

Bitkov, V. V.; Khashaev, Z. Kh. M.; Pronevich, L.A.; Nenashev, V. A.; Batrakov, C. G.

doi:10.1007/bf01054129

Cited by 3 publications

(5 citation statements)

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“…The formation of such bonds in a mixtures of resorcinolic lipids with phospholipids was indicated by infrared spectroscopic analysis. 179 In experiments with bacterial alkylresorcinols Batrakov and his colleagues showed that the saturated homologues could form stable black lipid membranes, 214,[236][237][238] especially at high pH (>7.5). It was also shown that, at pH >8.5, 5-n-pentadec(en)ylresorcinol from CNSL (cardol) forms vesicular structures, of 150 nm in diameter, that are able to entrap aqueous solutions.…”

Section: F Interaction Of Resorcinolic Lipids With Phospholipids Bila...mentioning

confidence: 99%

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

1998

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Section: F Interaction Of Resorcinolic Lipids With Phospholipids Bila...mentioning

confidence: 99%

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

1998

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“…This strategy could help us better understand the importance of mitochondrial OXPHOS efficiency for V O 2max and maximal running speed. Several natural substances have been described to cause mitochondrial uncoupling (6). Of these, fatty acids are effective uncouplers, but the protein component of the mitochondrial membrane is necessary to facilitate their translocation.…”

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confidence: 99%

Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations

Schlagowski

Singh

Charles

et al. 2014

Journal of Applied Physiology

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The effects of mitochondrial uncoupling on skeletal muscle mitochondrial adaptation and maximal exercise capacity are unknown. In this study, rats were divided into a control group (CTL, n = 8) and a group treated with 2,4-dinitrophenol, a mitochondrial uncoupler, for 28 days (DNP, 30 mg·kg(-1)·day(-1) in drinking water, n = 8). The DNP group had a significantly lower body mass (P < 0.05) and a higher resting oxygen uptake (Vo2, P < 0.005). The incremental treadmill test showed that maximal running speed and running economy (P < 0.01) were impaired but that maximal Vo2 (Vo2max) was higher in the DNP-treated rats (P < 0.05). In skinned gastrocnemius fibers, basal respiration (V0) was higher (P < 0.01) in the DNP-treated animals, whereas the acceptor control ratio (ACR, Vmax/V0) was significantly lower (P < 0.05), indicating a reduction in OXPHOS efficiency. In skeletal muscle, DNP activated the mitochondrial biogenesis pathway, as indicated by changes in the mRNA expression of PGC1-α and -β, NRF-1 and -2, and TFAM, and increased the mRNA expression of cytochrome oxidase 1 (P < 0.01). The expression of two mitochondrial proteins (prohibitin and Ndufs 3) was higher after DNP treatment. Mitochondrial fission 1 protein (Fis-1) was increased in the DNP group (P < 0.01), but mitofusin-1 and -2 were unchanged. Histochemical staining for NADH dehydrogenase and succinate dehydrogenase activity in the gastrocnemius muscle revealed an increase in the proportion of oxidative fibers after DNP treatment. Our study shows that mitochondrial uncoupling induces several skeletal muscle adaptations, highlighting the role of mitochondrial coupling as a critical factor for maximal exercise capacities. These results emphasize the importance of investigating the qualitative aspects of mitochondrial function in addition to the amount of mitochondria.

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“…There is a little information related to isolation of stepharine from plant tissues and organs [3, 6, 9, 10]. Obviously, these protocols poorly fit the isolation procedure from animal tissues and liquids.…”

Section: Resultsmentioning

confidence: 99%

“…Efficient extraction of stepharine from rabbit plasma needs to be applied for pharmacokinetic study. There is a little information related to isolation of stepharine from plant tissues and organs [ 3 , 6 , 9 , 10 ]. Obviously, these protocols poorly fit the isolation procedure from animal tissues and liquids.…”

Section: Resultsmentioning

confidence: 99%

“…Stephaglabrine sulfate affects the synaptic transmission and diminishes frequency of miniature endplate potential at low concentration [ 10 ]. It also inhibits cholinesterase and pseudocholinesterase in vitro [ 11 ] and possesses antihypertensive activity without side effects such as α - or β -adrenergic blockade, sedative or depressant effect.…”

Section: Resultsmentioning

confidence: 99%

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Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma

Kopylov

Kuznetsova

Mikhailova³

et al. 2014

Advances in Pharmacological Sciences

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Highly sensitive liquid chromatography mass spectrometry method on triple quadrupole (QQQ) mass spectrometer was successfully applied for pharmacokinetic study of stepharine in rabbit plasma. Specific ion transitions of stepharine protonated precursor ion were selected and recorded in the certain retention time employing dynamic selected reaction monitoring mode. The developed method facilitated quantitative measurements of stepharine in plasma samples in linear range of five orders of magnitude with high accuracy and low standard deviation coefficient and pharmacokinetics parameters were calculated. The apparent volume of stepharine distribution (estimated as ratio of clearance to elimination rate constant, data not shown) allows us to assume that stepharine was extensively distributed throughout the body.

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Effects of berberine, glaucine, stephaglabrine, and sanguirythrine on neuromuscular transmission

Cited by 3 publications

References 5 publications

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity

Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations

Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma

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