Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine<scp>monophosphate‐activated</scp>protein kinase/nuclear factor erythroid<scp>2‐related</scp>factor pathway and changes in the mitochondrial state

Xu, Chun; Liu, Yang; Zhai, Mengen; Fan, Zhenge; Qiao, Rui; Yang, Lifang

doi:10.1002/biof.1820

Cited by 10 publications

(10 citation statements)

References 48 publications

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“…The activation of Nrf2 and HO-1 has been demonstrated to protect against inflammatory intestinal injury, such as intestinal ischemia/reperfusion (I/R) injury ( Zu et al, 2018 ; Jin et al, 2019 ) and septic intestinal injury ( Yu et al, 2017 ). Additionally, the up-regulation of Nrf2 through drug intervention (e.g., berbamine) can also inhibit oxidative stress and inflammation to alleviate cardiac injury ( Xingyue et al, 2021 ; Hao et al, 2022 ; Xu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Dao-Chi Powder Ameliorates Pancreatitis-Induced Intestinal and Cardiac Injuries via Regulating the Nrf2-HO-1-HMGB1 Signaling Pathway in Rats

et al. 2022

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Dao-Chi powder (DCP) has been widely used in the treatment of inflammatory diseases in the clinical practice of traditional Chinese medicine, but has not been used in acute pancreatitis (AP). This study aimed to evaluate the effect of DCP on severe AP (SAP) and SAP-associated intestinal and cardiac injuries. To this end, an SAP animal model was established by retrograde injection of 3.5% taurocholic acid sodium salt into the biliopancreatic ducts of rats. Intragastric DCP (9.6 g/kg.BW) was administered 12 h after modeling. The pancreas, duodenum, colon, heart and blood samples were collected 36 h after the operation for histological and biochemical detection. The tissue distributions of the DCP components were determined and compared between the sham and the SAP groups. Moreover, molecular docking analysis was employed to investigate the interactions between the potential active components of DCP and its targets (Nrf2, HO-1, and HMGB1). Consequently, DCP treatment decreased the serum levels of amylase and the markers of gastrointestinal and cardiac injury, further alleviating the pathological damage in the pancreas, duodenum, colon, and heart of rats with SAP. Mechanistically, DCP rebalanced the pro-/anti-inflammatory cytokines and inhibited MPO activity and MDA levels in these tissues. Furthermore, Western blot and RT-PCR results showed that DCP intervention enhanced the expression of Nrf2 and HO-1 in the duodenum and colon of rats with SAP, while inhibiting the expression of HMGB1 in the duodenum and heart. HPLC-MS/MS analysis revealed that SAP promoted the distribution of ajugol and oleanolic acid to the duodenum, whereas it inhibited the distribution of liquiritigenin to the heart and ajugol to the colon. Molecular docking analysis confirmed that the six screened components of DCP had relatively good binding affinity with Nrf2, HO-1, and HMGB1. Among these, oleanolic acid had the highest affinity for HO-1. Altogether, DCP could alleviated SAP-induced intestinal and cardiac injuries via inhibiting the inflammatory responses and oxidative stress partially through regulating the Nrf2/HO-1/HMGB1 signaling pathway, thereby providing additional supportive evidence for the clinical treatment of SAP.

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Section: Introductionmentioning

confidence: 99%

Dao-Chi Powder Ameliorates Pancreatitis-Induced Intestinal and Cardiac Injuries via Regulating the Nrf2-HO-1-HMGB1 Signaling Pathway in Rats

et al. 2022

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“…Recently, a variety of natural products/phytochemicals, such as resveratrol, berberine, curcumin, and ASI, have been proven regulate the autophagy of cardiac myocytes in different ways. 19,20 The ability of new therapeutic drugs to modify autophagy has gradually become a new therapeutic target. More and more research shows that changes in autophagy are associated with myocardial injury in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway

Xu,

Xia,

et al. 2023

J Cellular Molecular Medi

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Diabetic cardiomyopathy (DCM) is a chronic microvascular complication of diabetes that is generally defined as ventricular dysfunction occurring in patients with diabetes and unrelated to known causes. Several mechanisms have been proposed to contribute to the occurrence and persistence of DCM, in which oxidative stress and autophagy play a non‐negligible role. Diabetic cardiomyopathy is involved in a variety of physiological and pathological processes. The 5′ adenosine monophosphate‐activated protein kinase/nuclear factor‐erythroid 2‐related factor 2 (AMPK/Nrf2) are expressed in the heart, and studies have shown that asiaticoside (ASI) and activated AMPK/Nrf2 have a protective effect on the myocardium. However, the roles of ASI and AMPK/Nrf2 in DCM are unknown. The intraperitoneal injection of streptozotocin (STZ) and high‐fat feed were used to establish the DCM models in 100 C57/BL mice. Asiaticoside and inhibitors of AMPK/Nrf2 were used for intervention. Cardiac function, oxidative stress, and autophagy were measured in mice. DCM mice displayed increased levels of oxidative stress while autophagy levels declined. In addition, AMPK/Nrf2 was activated in DCM mice with ASI intervention. Further, we discovered that AMPK/Nrf2 inhibition blocked the protective effect of ASI by compound C and treatment with ML‐385. The present study demonstrates that ASI exerts a protective effect against DCM via the potential activation of the AMPK/Nrf2 pathway. Asiaticoside is a potential therapeutic target for DCM.

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“…All the procedures were performed between 8:00 AM and 10:00 AM to reduce errors caused by circadian rhythms. [45,46] Experimental Protocol: The WAS model was referred to in our previous report. [47] Rats were placed on a platform (10 × 8 × 8 cm; length × width × height) in the center of a water-filled tank (45 × 25 × 35 cm; length × width × height) for 1 h per day for ten consecutive days in room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…All the procedures were performed between 8:00 AM and 10:00 AM to reduce errors caused by circadian rhythms. [ 45,46 ]…”

Section: Methodsmentioning

confidence: 99%

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

Xia,

Tan,

Yuan

et al. 2023

Molecular Nutrition Food Res

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ScopeIrritable bowel syndrome (IBS) is an intestinal disorder, whose symptoms can be alleviated by certain dietary phytochemicals. This study explores the role and potential mechanisms of a natural flavonoid luteolin (LUT) in alleviating the excessive motility of colonic smooth muscles and reducing oxidative stress in IBS with diarrhea (IBS‐D) rats.Methods and resultsLUT reduces excessive intestinal motility and lowers reactive oxygen species (ROS) levels in a water avoidance stress (WAS) rat model. Moreover, LUT increases the protein expression levels of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1), activates the nuclear translocation of Nrf2, and greatly reduces the hydrogen peroxide (H2O2)‐induced oxidative damage in intestinal epithelial cells.ConclusionsLUT, a phyto‐active component, protects against excessive intestinal motility and diarrhea by regulating the Nrf2 signaling pathway and effectively reduces oxidative stress damage in the colon.

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Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor pathway and changes in the mitochondrial state

Cited by 10 publications

References 48 publications

Dao-Chi Powder Ameliorates Pancreatitis-Induced Intestinal and Cardiac Injuries via Regulating the Nrf2-HO-1-HMGB1 Signaling Pathway in Rats

Dao-Chi Powder Ameliorates Pancreatitis-Induced Intestinal and Cardiac Injuries via Regulating the Nrf2-HO-1-HMGB1 Signaling Pathway in Rats

Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

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