Effects of Benidipine and Candesartan on Kidney and Vascular Function in Hypertensive Dahl Rats

Abstract

We examined the effect of the dihydropyridine calcium channel blocker (CCB) benidipine, the angiotensin II type 1 receptor blocker (ARB) candesartan, and the combination of these drugs on blood pressure and kidney and vascular function in rats with salt-induced hypertension. Dahl salt-sensitive (DS) rats were fed with a high-salt (8% NaCl) diet from 7 weeks of age. Benidipine (1, 3 mg/kg), candesartan (1, 3 mg/kg), benidipine

Calcium Channel Blockades Exhibit Anti-Inflammatory and Antioxidative Effects by Augmentation of Endothelial Nitric Oxide Synthase and the Inhibition of Angiotensin Converting Enzyme in the NG-Nitro-L-Arginine Methyl Ester-Induced Hypertensive Rat Aorta: Vasoprotective Effects beyond the Blood Pressure-Lowering Effects of Amlodipine and Manidipine

“…The calcium channel blockade amlodipine has been shown to limit the progression of arteriosclerosis and atherosclerosis in animals and humans (37,38). Although the mechanisms underlying the direct protective effects of calcium channel blockades on endothelial cell injury are not fully understood, such vasoprotective effects as the amelioration of endothelial dysfunction (39,40) and decreases in the proliferation of vascular smooth muscle cells (41), oxidative stress (37,42), and inflammation (43), are at least in part independent of the blood pressure-lowering effects of these agents. The calcium channel blockade has been shown to ameliorate hypertension and improve NO production in the vasculature and kidneys.…”

Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice

“…In addition, benidipine also appears to have renoprotective and vascular endothelial protective effects. 38 These results further suggest that the inhibition of aldosterone production and oxidative stresses contributes to the cardioprotective effect of benidipine and that benidipine provides a beneficial effect to multiple organs following cardiac I/R. In conclusion, benidipine, a calcium channel blocker, reduces I/R injury by inhibiting cardiac myocyte apoptosis, aldosterone production, oxidative stress and inflammation in mice.…”

Renoprotective Effect and Cost-Effectiveness of Using Benidipine, a Calcium Channel Blocker, to Lower the Dose of Angiotensin Receptor Blocker in Hypertensive Patients with Albumiuria

“…Benidipine, which blocks T-type and L-type calcium channels (8), decreases the resistance of the efferent and afferent arteries and lowers the glomerular capillary hydraulic pressure in rats (19,20). Yao et al reported renoprotective effects of benidipine in hypertensive Dahl rats (21,22). Therefore, benidipine is expected to have a renoprotective effect also in hypertensive patients.…”