Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers

Alassaf, Fawaz A.; Jasim, Mahmood H. M.; Alfahad, Mohanad; Qazzaz, Mohannad E.; Abed, Mohammed N.; Thanoon, Imad A.

doi:10.4274/tjps.galenos.2020.50024

Cited by 12 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, Samadi et al reported that consumption of 900 mg of propolis for 12 weeks reduced FBG in people with T2DM with no concomitant changes in insulin, insulin resistance, HDL-c, or TG (Samadi et al, 2017). In another study, after 60 days of supplementation with 1000 mg of propolis, Alassaf et al observed a significant decrease in FBG (Alassaf et al, 2021). Our findings for FBG are consistent with the aforementioned results.…”

Section: Discussionsupporting

confidence: 91%

The effects of propolis supplementation on high‐sensitivity C‐reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple‐blinded, placebo‐controlled clinical trial

Abbasi,

Bagherniya,

Soleimani

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

One of the most prevalent ovulation disorders is polycystic ovarian syndrome (PCOS). According to the anti‐inflammatory and beneficial effects of propolis, this triple‐blind controlled trial was designed to evaluate the effect of propolis on metabolic factors, high‐sensitivity C‐reactive protein, and testosterone in women with PCOS. Recruited patients from the gynecologist clinic were randomized based on a stratified permuted four‐block randomization procedure to supplement with propolis tablets, two tablets/day (500 mg propolis/day) (n = 30) or identical placebo tablets (n = 30) for 12 weeks in 2021 until 2022. Data were collected using a demographic questionnaire, blood samples, and a checklist to record the measured parameters. A total of 57 patients completed the trial. ANCOVA test showed that hip circumference (HC)) p = 0.03), fasting insulin (p = 0.007), homeostatic model assessment for insulin resistance (p = 0.004), testosterone (p = 0.004), and low‐density lipoprotein (LDL)/high‐density lipoprotein (HDL) (p = 0.02) were significantly decreased in the propolis versus the placebo group after adjustment for confounders. Although fasting blood glucose (p = 0.04) decreased significantly in the propolis group compared to the placebo, after adjusting for confounders, significance was lost (p = 0.09). Supplementation with propolis elicited positive effects on fasting insulin and insulin resistance, in addition to reducing the testosterone level, LDL/HDL, and HC, in PCOS women.

show abstract

Section: Discussionsupporting

confidence: 91%

The effects of propolis supplementation on high‐sensitivity C‐reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple‐blinded, placebo‐controlled clinical trial

Abbasi,

Bagherniya,

Soleimani

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…These interesting reports about the activity of propolis motivated this research team to study the effects of bee propolis on thyroid functions. In a previous study by the same team which evaluated effects of bee propolis on fasting blood glucose, glycosylated haemoglobin and insulin sensitivity in healthy subjects, an increase in body weight and BMI, as well as a decrease in FBG and HbA1c levels in healthy individuals were reported [8]. In the current study, the effects of bee propolis on thyroid function tests are reported to evaluate an additional aspect of its safety in healthy individuals.…”

Section: Introductionmentioning

confidence: 84%

“…This correlation was argued in our previous study on bee propolis and the glycemic control. The potential mechanism of the increased body weight could be explained by increased volunteers' appetite or enhanced peripheral tissue glucose uptake [8].…”

Section: Discussionmentioning

confidence: 99%

Effects of bee propolis on thyroid function tests in healthy volunteers

Alassaf¹,

Qazzaz²,

Alfahad³

et al. 2022

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

Purpose: The current study investigates the effects of bee propolis as a dietary supplement on thyroid function in healthy individuals. Methods: Sixty-nine apparently healthy subjects of both genders aged between 25 and 45 years and had a body mass index in the range of 18.5-25 kg m-2 were enrolled in the study. The participants were divided into two groups, 34 volunteers treated with 1 gram of bee propolis daily and the other 35 were on placebo pills for 2 months. Total triiodothyronine (TT3), total thyroxine (TT4) and ultra-sensitive thyroid stimulating hormone (USTSH) were measured in the two groups before and after treatment to assess thyroid function. Results: The results showed a significant increase in body weight (from 73.4 ± 7.2 to 74.8 ± 7.5 kg, p < 0.05) and BMI (from 24.2 ± 1.2 to 24.7 ± 1.5 kg m-2 , p < 0.05) with significantly decreased TT3 (from 2.17 ± 0.07 to 1.87 ± 0.09 nmol/L, p < 0.01) in bee propolis-treated group, whereas TT4 and USTSH showed non-significant changes. Conclusion: The results reveal a significant association of bee propolis supplementation with reduced TT3 levels in healthy subjects. The link may assist clinicians in monitoring the safety of bee propolis supplementation.

show abstract

“…Nonetheless, significant differences were observed between two groups for WC, but not regarding BMI and body weight. In three previous interventional studies that assessed the effects of propolis on WC measurement [44][45][46] , propolis had no considerable effects on WC. In addition, some clinical trials 23,27,34,[43][44][45][46] indicated that propolis consumption had no favorable effects on weight and BMI.…”

Section: Discussionmentioning

confidence: 99%

“…In three previous interventional studies that assessed the effects of propolis on WC measurement [44][45][46] , propolis had no considerable effects on WC. In addition, some clinical trials 23,27,34,[43][44][45][46] indicated that propolis consumption had no favorable effects on weight and BMI. However, a clinical trial showed that daily intake of 900 mg of raw propolis supplementation for 12 weeks in diabetic subjects could reduce weight and BMI 24 .…”

Section: Discussionmentioning

confidence: 99%

Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial

Sajjadi

Bagherniya

Soleimani

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Metabolic syndrome (MeS) is a common multifaceted disorder. Plants contain antioxidant bioactive compounds, which are beneficial to improve the health condition of patients with MeS. Propolis is a hive natural product that is composed of various constituent. We aimed to assess the effects of Iranian propolis as a natural and safe agent on indicators of MeS, quality of life and mood status in individuals with MeS. In total, 66 interested eligible patients recruited to the present study. Participants were randomly assigned to consume a tablet at dose of 250 mg of propolis extract, twice daily for 12 weeks or placebo. Propolis supplementation could lead to a significant reduction in waist circumference (WC), increase in physical functioning, general health and the overall score of SF-36 compared with placebo group (P-value < 0.05). However, no significant differences were observed regarding other anthropometric indices and biochemical parameters between two groups (P-value > 0.05). The current study indicated that propolis can be effective in decreasing WC and improving physical health and quality of life, while had no significant effects on other components of MeS among subjects with this syndrome. Clinical trials registration Iran Registry of Clinical Trials.ir IRCT20121216011763N49, registration date 23/12/2020.

show abstract

Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers

Cited by 12 publications

References 29 publications

The effects of propolis supplementation on high‐sensitivity C‐reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple‐blinded, placebo‐controlled clinical trial

The effects of propolis supplementation on high‐sensitivity C‐reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple‐blinded, placebo‐controlled clinical trial

Effects of bee propolis on thyroid function tests in healthy volunteers

Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial

Contact Info

Product

Resources

About