Effects of Bay Leaves on the Patients with Diabetes Mellitus

Aljamal, Abdulrahim

doi:10.3923/rjmp.2011.471.476

Cited by 22 publications

(17 citation statements)

References 4 publications

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“…Laurus nobilis leaves are commonly used in culinary purposes as spice. The anti-diabetic potential [40,41] and in vitro antiglycation potential of L. nobilis is reported [42]. In our studies, we have also found that L. nobilis has in vivo antiglycation potential.…”

Section: Laurus Nobilissupporting

confidence: 76%

Preventing Diabetic Complications by Dietary Agents

Hafizur

2019

CRDOJ

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Diet is vital for survival whereas balanced diet and nutrition are crucial for healthy living. Dietary agents, such as fruits, vegetables, and spices; are consumed in daily meals. Dietary agents are available and affordable all over the world which makes them suitable candidate for preventing diabetic complications. The scientific validation for their health-related benefits and anti-diabetic potential; mainly, is a big trumpet for their usefulness in indigenous cultures all around the world. In order to successfully manage diabetes, medicinal and nutritional interventions are supposed to go hands in hands. At present, medicines are available for diabetes managements; but diabetic complications are completely ignored. Therefore, dietary agents should be given more emphasis for the prevention and/or management of diabetes related complication. Dietary agents are rich in nutritional values and daily consumption makes them more palatable. In this regard, dietary agents may play an important role for preventing diabetic complication.

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Section: Laurus Nobilissupporting

confidence: 76%

Preventing Diabetic Complications by Dietary Agents

Hafizur

2019

CRDOJ

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“…The primary in vivo model identified for studying the anti-diabetic activity of these plant extracts was either streptozotocin-induced or alloxan-induced diabetic rats. Aniseed [32], bay leaves [44,45,210], cardamom [211], cinnamon [66,211], cumin [212,213], dill [214], ginger [211], hops [118], rosemary [215], saffron [211,216], sage [217,218], and turmeric [219] have also been evaluated in type 2 diabetic patients. The major in vivo effects observed for the herbs and spices are a reduction in hyperglycemia and hyperlipidemia.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening

et al. 2019

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Culinary herbs and spices are widely used as a traditional medicine in the treatment of diabetes and its complications, and there are several scientific studies in the literature supporting the use of these medicinal plants. However, there is often a lack of knowledge on the bioactive compounds of these herbs and spices and their mechanisms of action. The aim of this study was to use inverse virtual screening to provide insights into the bioactive compounds of common herbs and spices, and their potential molecular mechanisms of action in the treatment of diabetes. In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasaponin I from fenugreek, bisdemethoxycurcumin from turmeric, carlinoside from lemongrass, cinnamtannin B1 from cinnamon, crocin from saffron and glabridin from liquorice. The major targets identified for the herbs and spices compounds were dipeptidyl peptidase-4 (DPP4), intestinal maltase-glucoamylase (MGAM), liver receptor homolog-1 (NR5A2), pancreatic alpha-amylase (AM2A), peroxisome proliferator-activated receptor alpha (PPARA), protein tyrosine phosphatase non-receptor type 9 (PTPN9), and retinol binding protein-4 (RBP4) with over 250 compounds observed to be potential inhibitors of these particular protein targets. Only bay leaves, liquorice and thyme were found to contain compounds that could potentially regulate all 18 protein targets followed by black pepper, cumin, dill, hops and marjoram with 17 protein targets. In most cases more than one compound within a given plant could potentially regulate a particular protein target. It was observed that through this multi-compound-multi target regulation of these specific protein targets that the major anti-diabetic effects of reduced hyperglycemia and hyperlipidemia of the herbs and spices could be explained. The results of this study, taken together with the known scientific literature, indicated that the anti-diabetic potential of common culinary herbs and spices was the result of the collective action of more than one bioactive compound regulating and restoring several dysregulated and interconnected diabetic biological processes.

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“…L. nobilis ground leaves ingestion (1-3 g/day; 30 days) was reported to improve insulin function, decrease serum levels of glucose, total cholesterol, low density lipoprotein cholesterol (LDL), and increase high density lipoprotein cholesterol (HDL) in humans with type II diabetes (Khan et al, 2009). Same treatment administered to type I diabetic patients resulted in similar beneficial effects (Aljamal, 2011). Cookies containing bay leaf powder (not less than 6% w/w) exhibited significant benefit on postprandial glucose level in healthy human subjects (Khan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats

Daher¹,

Taleb²,

Mroueh³

et al. 2021

J. Pharmacognosy Phytother.

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Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight, respectively), and groups 5, 6, and 7 (bay leaves methanol/acetone (MeAc) extract; 50, 100, and 250 mg/kg of body weight, respectively). Animals were fed an isocaloric high fat diet for four weeks. The intake of bay leaves extracts was associated with a significant decreases in serum levels of glucose (AQ, 100 and 250 mg/kg; MeAc, 50, 100, and 250 mg/kg) and serum triglyceride (AQ, 250 mg/kg; MeAc, 100, and 250 mg/kg) as well as lower abdominal fat (all AQ and MeAc groups) and body weight gain (MeAc groups only). In conclusion, L. nobilis leaves extract intake provides a protective remedy against high fat diet-induced type 2 diabetes.

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Effects of Bay Leaves on the Patients with Diabetes Mellitus

Cited by 22 publications

References 4 publications

Preventing Diabetic Complications by Dietary Agents

Preventing Diabetic Complications by Dietary Agents

Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening

Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats

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