Effects of Bariatric Surgery on Inflammatory, Functional and Structural Markers of Coronary Atherosclerosis

Habib, Phillip; Scrocco, John; Terek, Megan; Vanek, Vincent W.; Mikolich, J. Ronald

doi:10.1016/j.amjcard.2009.06.042

Cited by 91 publications

(46 citation statements)

References 22 publications

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“…In our study, mean triglyceride level dropped by 122 mg/dL after 1-year follow up. As previously described, bariatric surgery results in 30 % to 40 % reduction in triglyceride concentration [38,41]. We want to emphasize that the benefit on improvement of cholesterol fractions of RYGB surgery are greater than those obtained with available pharmacological strategies for severely obese patients.…”

Section: Discussionmentioning

confidence: 93%

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Fallahi-shahabad

Mazidi

Tavasoli

et al. 2016

Indian J Gastroenterol

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Section: Discussionmentioning

confidence: 93%

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Fallahi-shahabad

Mazidi

Tavasoli

et al. 2016

Indian J Gastroenterol

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“…26 Previous studies demonstrated that long-term weight loss after bariatric surgery is accompanied by a decreased proinflammatory state. Bariatric surgery decreased circulating levels of c-reactive protein (CRP), 27-30 IL-6, 29 serum amyloid A (SAA), 31-32 and leptin, 8 but increased the circulating level of adiponectin. 8 Bariatric surgery also reduced subcutaneous adipose tissue macrophage attraction, and gene expression of inflammatory cytokines, such as TNFα and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Bariatric Surgery Reduces Visceral Adipose Inflammation and Improves Endothelial Function in Type 2 Diabetic Mice

Zhang

Wang

Zhang

et al. 2011

ATVB

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Objective Bariatric surgery is emerging as an effective method to alleviate a multitude of medical conditions associated with morbid obesity and type 2 diabetes. However, little is known about the effects and mechanisms of bariatric surgery on visceral fat inflammation and endothelial dysfunction in type 2 diabetes. We hypothesize that bariatric surgery ameliorates interferon-gamma (IFNγ-mediated adipose tissue inflammation/oxidative stress and improves endothelial function in type 2 diabetic mice. Methods and Results Control mice (m Leprdb) and diabetic mice (Leprdb) were treated with either sham surgery or Improved Gastric Bypass Surgery (IGBS) and then evaluated at 5, 10, 20, and 30 days to assess post-surgical effects. Surgery reduced body weight, abdominal adiposity, blood glucose level, and food intake in Leprdb. The surgery-induced decrease in visceral adiposity was accompanied by amelioration of T-lymphocytes and macrophage infiltration, as well as reduction in the expression of IFNγ and other inflammatory cytokines in the mesenteric adipose tissue (MAT) of Leprdb mice. Furthermore, surgery improved endothelium-dependent, but not endothelium-independent vasorelaxation in small mesenteric arteries (SMA) of Leprdb mice. The improvement in endothelial function was largely attenuated by nitric oxide synthase inhibitor (L-NAME) incubation. IFNγ treatment increased the mRNA expression of tumor necrosis factor-alpha (TNFα) in the MAT of control mice, and incubation of SMA of control mice with TNFα caused impairment of endothelial function. Superoxide production in MAT/SMA and nitrotyrosine protein level in SMA were elevated in diabetic mice. Surgery reduced MAT/SMA oxidative stress in Leprdb mice. Conclusions The amelioration of adipose tissue inflammation and the improvement of endothelial function may represent important mechanisms that result in cardiovascular benefits following bariatric surgery.

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“…In fact, bariatric surgery was recently recognized as a valid treatment option for type 2 diabetes in obese patients by both the International Diabetes Federation and the American Diabetes Association. Further, long-term (6-year) remission rates post-gastric bypass reached up to 31% in a study by Brethauer et al [17] and up to 72% in the Swedish Obese Subjects Study (SOS; with a follow-up of 2 years) [18], and result in improvements in cardiovascular function [19]. Biliopancreatic diversion (BPD) with or without duodenal switch (DS) is frequently used and has shown improvement in insulin and glucose metabolism in most patients [20].…”

Section: Introductionmentioning

confidence: 99%

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease

Lapointe

Poirier

Martin

et al. 2014

Cardiovasc Diabetol

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BackgroundAlthough no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, insulin resistance, metabolic syndrome and chronic inflammation.MethodsChanges in Omentin levels at 1 and 5 days and 6 and 12 months in response to biliopancreatic diversion with duodenal switch bariatric surgery were evaluated, specifically to investigate if changes preceded gain of insulin sensitivity.ResultsPre-operative plasma Omentin was not different between men (n = 18) vs women (n = 48), or diabetic status but correlated with body mass index (BMI). Altogether, Omentin increased as early as 24-h post-surgery, with changes maintained up to 1-year. Fifty-nine percent of subjects increased Omentin >10% by 24-H following surgery (OmentinINC p < 0.0001), while 18% of subjects decreased (OmentinDEC p < 0.0001), with changes maintained throughout one-year. These two groups had comparable age, sex distribution, diabetes, BMI, waist circumference and fat mass, however OmentinDEC had elevated levels of cardiovascular risk markers; homocysteine (p = 0.019), NT-proBNP (p = 0.006) and total bilirubin (p = 0.0001) while red blood cell (RBC) count was lower (p = 0.0005) over the one-year period. Omentin levels at 1-DAY also correlated with immune parameters (white blood cell count, % neutrophil, % monocytes, % lymphocytes).ConclusionOmentinDEC at 1 day following surgery may be a marker of cardiovascular “at-risk” group before weight loss or insulin sensitivity restoration.

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Effects of Bariatric Surgery on Inflammatory, Functional and Structural Markers of Coronary Atherosclerosis

Cited by 91 publications

References 22 publications

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Bariatric Surgery Reduces Visceral Adipose Inflammation and Improves Endothelial Function in Type 2 Diabetic Mice

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease

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