Effects of Bariatric Surgery in Male Obesity-Associated Hypogonadism

Rigon, F; Ronsoni, Marcelo Fernando; Hohl, Alexandre; Sande‐Lee, Simone van de

doi:10.1007/s11695-019-03829-0

Cited by 19 publications

(11 citation statements)

References 47 publications

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“…In 2019, Rigon et al37 reported a study of 29 male patients with severe obesity and T2D who underwent RYGB or SG and were compared with an age-matched control group of 29 normal-weight men. The surgical group had a mean baseline testosterone of 2.29 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

Testosterone Changes in Men With Obesity and Type 2 Diabetes 6 Months After Sleeve Gastrectomy With Transit Bipartition

Taşkın

Al²

2022

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: Metabolic/bariatric surgery has been shown to increase testosterone in males with obesity. This study investigated the effect of the novel metabolic/bariatric surgery procedure, sleeve gastrectomy with transit bipartition (SG-TB), on serum total testosterone and metabolic variable changes in men with obesity and type 2 diabetes.Methods: In a prospective single-center cohort study, laboratory samples were analyzed preoperatively and at 6 months following SG-TB in patients with a body mass index (BMI) ≥ 30 kg/m 2 . Changes in metabolic parameters and testosterone were evaluated.

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Section: Discussionmentioning

confidence: 99%

Testosterone Changes in Men With Obesity and Type 2 Diabetes 6 Months After Sleeve Gastrectomy With Transit Bipartition

Taşkın

Al²

2022

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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“…Bariatric surgery in obese males also improves sexual dysfunction, including erectile dysfunction, libido, and satisfaction with sexual intercourse [ 142 , 143 ]. Lower levels of seminal lipid peroxidation were reported after bariatric surgery, along with improved semen parameters, mitochondrial activity, and sperm DNA integrity [ 144 ], and improved testosterone in male obesity-associated secondary hypogonadal patients [ 145 ]. Bariatric surgery further improves the inflammatory and oxidative stress markers in males and females [ 146 , 147 ].…”

Section: Management Of Male Hypogonadism Associated With Non-communicable Chronic Diseasesmentioning

confidence: 99%

The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

Leisegang¹,

Roychoudhury

Sláma

et al. 2021

Antioxidants

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Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly seen in ageing males, and has a complex relationship as a risk factor and a comorbidity in age-related noncommunicable chronic diseases (NCDs), such as obesity, metabolic syndrome, type 2 diabetes, and malignancy. Oxidative stress, as a significant contributor to the ageing process, is a common feature between ageing and NCDs, and the related comorbidities, including hypertension, dyslipidemia, hyperglycemia, hyperinsulinemia, and chronic inflammation. Oxidative stress may also be a mediator of hypogonadism in males. Consequently, the management of oxidative stress may represent a novel therapeutic approach in this context. Therefore, this narrative review aims to discuss the mechanisms of age-related oxidative stress in male hypogonadism associated with NCDs and discusses current and potential approaches for the clinical management of these patients, which may include conventional hormone replacement therapy, nutrition and lifestyle changes, adherence to the optimal body mass index, and dietary antioxidant supplementation and/or phytomedicines.

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“…These aberrations may be attributed to lack of glucose entry into hypothalamus and various Pituitary cells as well as Pituitary dependent endocrine cells induced by insulin deficiency in type 1 and insulin resistance in type 2 diabetes. Furthermore, thyroid hormonal changes in various "Euthyroid Sick States" and gonadal dysfunction in PCOS and obese subjects are also attributed to insulin resistance at the level of thyroid gland as well as hormonal metabolism in peripheral tissues as well as on the part of ovarian theca cells respectively [147] [154]- [163]. Alternatively, metabolemic changes in several chronic disorders including HIV syndrome, chronic renal failure, malignancy etc.…”

Section: Hypothalamic Pituitary Dysfunctionmentioning

confidence: 99%

“…[162] [163] [167][168] [169] [170][171].Finally, improved outcomes e.g. prompt remission, delay or prevention of recurrences as well as longer survival are reported recently by adjunctive therapy with Metformin or thiazolidinediones in combination with chemotherapy in subjects with various cancers[168] [169][170].…”

mentioning

confidence: 99%

Diabetes Mellitus: Disorder of Cellular Dysfunction Due to Lack of Entry into Cell of Glucose. The Most Efficient Fuel for Cellular Function*

Kabadi¹

2021

OJEMD

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Background: Diabetes Mellitus is established to be a chronic hyperglycemic disorder secondary to altered glucose metabolism. Alternatively, hyperglycemia may be one of several manifestations in subjects with type 1 and type 2 diabetes Mellitus. Most tissues require insulin for entry of glucose, exceptions being red blood cells, renal medulla and nervous system. Hyperglycemia in intravascular compartment and other extra cellular milieu may be attributed to impaired glucose entry into endothelial cells of the vessel wall and cells in other tissues due to absence of insulin in type 1 and both insulin resistance and decline in insulin secretion in type 2 Diabetes. Objective: Hypothesis is proposed that Diabetes mellitus is a disorder of cellular dysfunction due to lack of entry of glucose, the most efficient fuel. Literature review was conducted to establish the perspective. Results: Declines in both phases of insulin secretion are induced by lack of glucose entry into pancreatic beta cells. Hyperglycemia is perpetuated by increased hepatic glucose production caused by sustained hyperglucagonemia secondary to lack of glucose entry into the pancreatic alpha cells. Moreover, decline in insulin secretion by beta cells and rise in glucagon release by alpha cells are enhanced by fall in GLP1 and GIP caused by dysfunction of L cells and K cells secondary to lack of glucose entry in both types of diabetes. Increased prevalence of infections and thromboembolic events may be attributed to dysfunction of leukocytes and platelets due to impaired glucose entry. Finally, alterations in metabolemics including Adiponectin, TNF alpha, Plasminogen inhibitor factor 1, Homocysteine, CRP, Lipids etc. as

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Effects of Bariatric Surgery in Male Obesity-Associated Hypogonadism

Cited by 19 publications

References 47 publications

Testosterone Changes in Men With Obesity and Type 2 Diabetes 6 Months After Sleeve Gastrectomy With Transit Bipartition

Testosterone Changes in Men With Obesity and Type 2 Diabetes 6 Months After Sleeve Gastrectomy With Transit Bipartition

The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

Diabetes Mellitus: Disorder of Cellular Dysfunction Due to Lack of Entry into Cell of Glucose. The Most Efficient Fuel for Cellular Function*

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