Effects of balanced deep‐sea water on adipocyte hypertrophy and liver steatosis in high‐fat, diet‐induced obese mice

Ha, Byung Geun; Park, Jung-Eun; Shin, Eun Ji; Shon, Yun Hee

doi:10.1002/oby.20740

Cited by 30 publications

(36 citation statements)

References 40 publications

(44 reference statements)

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“…DOW not only demonstrated hypolipidemic effects but also improved the health functions of fatty livers. Another study indicated that DOW suppresses lipogenesis and cholesterol synthesis in the liver, increases β-oxidation-related gene expression, and improves the phosphorylation of IRS-1, LKB1, AMPK, and mTOR in fat and liver tissues (Ha et al 2014). …”

Section: Prevention Of Cardiovascular Diseasementioning

confidence: 99%

The advantages of deep ocean water for the development of functional fermentation food

Lee¹

2015

Appl Microbiol Biotechnol

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Deep ocean water (DOW) is obtained from 600 m below the sea surface. In recent years, DOW has been applied in the development of fermentation biotechnologies and functional foods. DOW is rich in trace minerals, comprises multiple physiological and health functions, and is able to promote microbe growth; therefore, the application of DOW directly benefits the development of the fermentation industry and functional foods. This study integrated the current health functions and applications of DOW with the latest results from studies related to fermentation biotechnology. Subsequently, the influence of applying DOW in fermented functional food development and the effects in health function improvements were summarized. According to the previous studies, the main reasons for the increased effect of fermented functional foods through the application of DOW are increased generation of functional metabolite contents in the microbes, intrinsic health functions of DOW, and the microbial use of mechanisms of converting the absorbed inorganic ions into highly bioavailable organic ions for the human body. These combined advantages not only enhance the health functions of fermentation products but also provide fermentation products with the intrinsic health functions of DOW.

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Section: Prevention Of Cardiovascular Diseasementioning

confidence: 99%

The advantages of deep ocean water for the development of functional fermentation food

Lee¹

2015

Appl Microbiol Biotechnol

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“…Numerous studies have confirmed that DSW has pharmacological effects, including protecting the cardiovascular system (12,13), improving metabolic processes (14,15), anti-osteoporosis properties (16), treating atopic dermatitis skin lesions (17), accelerating recovery from physical fatigue (18), providing intestinal protection against duodenal ulcers (9) and inhibiting the metastatic potential of human breast cancer cell lines (19 Although DSW has already been studied for its alleviating fatigue effect in Wistar rats, the beneficial effects isolated in that study were only attributed to the minerals of DSW (20). In addition, the mechanism behind the beneficial effect has not yet been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Fan¹,

Tan²,

Yue³

et al. 2016

Biomedical Reports

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Abstract. Physical fatigue is extremely common and occurs daily, and is considered to be associated with oxidative stress. The diverse functions of deep sea water (DSW) have recently gained increasing attention. Previous studies have emphasized the anti-fatigue effect of DSW, but the intrinsic mechanism behind the effect remains to be elucidated. In the imprinting control region (ICR) mice model, DSW delayed the exhaustive swimming time. In addition, DSW decreased the area under the blood lactate (BLA) curve, which was associated with the area under the BLA curve of pre-swimming, post-swimming and post-rest. Furthermore, DSW reduced the basal levels of malondialdehyde and the post-swimming concentration of blood urea nitrogen, lactate dehydrogenase and creatine kinase after swimming, along with an increase in the normal level of antioxidant enzyme activity such as superoxide dismutase and glutathione peroxidase. However, no significant effect on body weight, hepatic glycogen and muscle glycogen was observed between any group. In conclusion, DSW can improve the athletic ability and alleviate physical fatigue of ICR mice. This effect is achieved by enhancing the antioxidant capacity.

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“…From each sample, total RNA (10 µg) was reverse transcribed into cDNA using the Moloney murine leukemia virus transcriptase and Oligo(dT) 15 Statistical analysis. All data are expressed as the mean ± standard error of the mean and differences between the groups were analyzed using a Student's t-test.…”

Section: Reverse Transcription-polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

“…Deep sea water (DSW) generally refers to sea water from a depth of >200 m (11). DSW has been the subject of many studies due to its high content of inorganic nutrients such as magnesium (Mg), calcium (Ca), potassium (K), zinc (Zn) and vanadium (V), and has been indicated to be associated with prevention of obesity (11)(12)(13)(14)(15). Sesame (Sesamum indicum L.), which is an annual herbaceous plant, has long been an ingredient in human foods (16).…”

Section: Introductionmentioning

confidence: 99%

Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue

Yuan

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the protective effects of a combination of deep sea water (DSW) and Sesamum indicum leaf extract (SIE) against high-fat diet (HFD)-induced obesity and investigate its molecular mechanisms in adipose tissue. ICR mice were randomly divided into three groups: HFD control (HFC), DSW and DSW + 125 mg/kg SIE (DSS) groups. The mice in the HFC group had free access to drinking water while those in the DSW and DSS groups had free access to DSW. The mice in the DSS group were treated with SIE once per day for 8 weeks. The mice in all three groups were allowed to freely access a HFD. Compared with the HFC group, the DSS group showed lower body weight gain and serum levels of glucose, triglycerides and leptin. Histological analyses of the epididymal white, retroperitoneal white and scapular brown adipose tissue of mice in the DSS group revealed that the adipocytes were markedly decreased in size compared with those in the HFC group. Moreover, DSS significantly increased the levels of phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase (ACC) in mice epididymal adipose tissues. Furthermore, DSS upregulated the expression levels of lipolysis-associated mRNA, specifically peroxisome proliferator-activated receptor-α (PPAR-α) and cluster of differentiation 36 (CD36), and energy expenditure-associated mRNA, namely uncoupling protein 2 (UCP2) and carnitine palmitoyltransferase-1 (CPT1) in the epididymal adipose tissues. By contrast, DSS suppressed the expression of the lipogenesis-related gene sterol regulatory element-binding protein-1 (SREBP1) at the mRNA level. These results suggest that DSS is effective for suppressing body weight gain and enhancing the lipid profile.

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Effects of balanced deep‐sea water on adipocyte hypertrophy and liver steatosis in high‐fat, diet‐induced obese mice

Cited by 30 publications

References 40 publications

The advantages of deep ocean water for the development of functional fermentation food

The advantages of deep ocean water for the development of functional fermentation food

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue

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