Effects of “Bacuri” Seed Butter (Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia

Abstract

This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)—maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)—maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing p < 0.05 the atherogenic index, coronary artery risk index, and LDL/CT ratio p < 0.05 and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.

Perspectivas do uso de extratos de plantas amazônicas (açaí, copaíba, salva-do-marajó, pupunha e bacuri) como potenciais moduladores da fermentação ruminal: um breve panorama

“…Devido à presença desses compostos fitoquímicos, a polpa de açaí apresenta alta capacidade antioxidante, principalmente, pela presença de luteolina, quercetina e diidrocaempferol, que podem contribuir com a redução do estresse oxidativo causado dentro das células (24) . Em ensaios in vitro, o óleo da polpa de açaí mostra efeito inibitório no crescimento de bactérias gram-positivas (Staphylococcus aureus, Enterococcus faecalis) (32,36) .…”

The Platonia insignis Mart. as the Promising Brazilian ‘Amazon Gold’: The State-of-the-Art and Prospects

“…Furthermore, studies have shown that bacuri seed oil possesses an important healing activity and it can be used in the treatment of burns and wounds [34,38]. Moreover, recently, in vivo studies point to an important potential antioxidant and cardioprotective action [39,40].…”

“…Compounds extracted from the shell, seeds, flowers, and stem bark have shown that parts of the plant can be used as an alternative in the treatment of various diseases. Its potential as cardioprotective [39,47], vasorelaxant [48], leishmanicidal [49], immunomodulatory [38], and for glycemic control [50], among others, has been reported in a variety of studies (Table 7). These effects are associated with the presence of compounds derived from terpenes, xanthones, and phenolics, in addition to saturated and unsaturated fatty acids, as can be seen in Figure 3.…”

“…These effects are associated with the presence of compounds derived from terpenes, xanthones, and phenolics, in addition to saturated and unsaturated fatty acids, as can be seen in Figure 3. Hypolipidemic Seed Unsaturated fatty acids, xanthones, prenylated benzophenone [39] Legend: (*) Compounds not specified. There is excellent potential for bacuri to develop drugs of natural origin, which have added economic value to the fruit, including the inedible parts of the plant [52].…”

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

“…Previous studies have investigated the effect of food derived-by products from grapes [ 37 , 44 ], beetroot [ 43 ], apricot [ 41 , 42 ], jaboticaba [ 15 , 23 ], onion [ 25 ], cranberry [ 24 ], pear [ 16 ], olive [ 26 ], peach [ 17 ], blueberry [ 31 ], and bacuri [ 33 ] on serum lipids. Araújo et al [ 23 ] investigated the effect of jaboticaba peel flour supplementation in rats fed with a hyperlipidemic diet for 4 weeks.…”