Effects of bacteria on male fertility: Spermatogenesis and sperm function

Oghbaei, Hajar; Rezaei, Yeganeh Rastgar; Nikanfar, Saba; Zarezadeh, Reza; Sadegi, Mohammadreza; Latifi, Zeinab; Nouri, Mohammad; Fattahi, Amir; Ahmadi, Yasin; Bleisinger, Nathalie

doi:10.1016/j.lfs.2020.117891

Cited by 25 publications

(27 citation statements)

References 150 publications

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“…Escherichia coli is one of the most frequent species found in human semen 6 , 7 and in genitourinary infections 8 , in particular epididymitis 9 . E. coli rapidly adheres to human spermatozoa in vitro, resulting in agglutination of spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

“…Evaluation of the direct effects of bacteria on sperm functions in vitro is of great help in understanding the role of infections in male infertility. So far, most in vitro studies evaluating the effects of Enterobacteriaceae on human spermatozoa, employed E. coli strains as pathogen (for review see 2 , 8 ). In addition, most studies were limited to evaluate the effect of E. coli on human sperm motility and viability, and have been performed on highly motile selected sperm populations 11 – 15 , which are poorly representative of the real environment where bacteria, present in the male genital tract, may produce the damage.…”

Section: Introductionmentioning

confidence: 99%

“…Inhibitory effect of E. coli on sperm motility have been attributed to release of SIF 2 , 8 , however, whether SIF is involved in the inhibitory effect of other bacterial species is presently less clear, nor it is known the role of this factor in other sperm alterations due to bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

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Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions

Marchiani

Baccani

Mattiuz

et al. 2021

Sci Rep

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Male genitourinary tract (MGT) bacterial infections are considered responsible for 15% of male infertility, but the mechanisms underlying decreased semen quality are poorly known. We evaluated in vitro the effect of strains of Gram-negative uropathogenic species (two E.coli strains, three K. pneumoniae strains, P. aeruginosa and E. cloacae) on motility, viability, mitochondrial oxidative status, DNA fragmentation and caspase activity of human spermatozoa. All strains, except P. aeruginosa, reduced significantly sperm motility, with variable effects. Sperm Immobilizing Factor (SIF) was largely responsible for deteriorating effects on sperm motility of E. coli strains since they were completely reverted by knockout of SIF coding recX gene. Sequence alignment for RecX showed the presence of high homologous sequences in K. pneumoniae and E. cloacae but not in P. aeruginosa. These results suggest that, in addition to E.coli, other common uropathogenic Gram-negative bacteria affect sperm motility through RecX products. In addition to sperm motility, the E. coli strain ATCC 35218 also affected sperm viability, and induced caspase activity, oxidative stress and DNA fragmentation suggesting an interspecies variability in the amount and/or type of the produced spermatotoxic factors. In general, our results highlight the need for a careful evaluation of semen infections in the diagnostic process of the infertile man.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions

Marchiani

Baccani

Mattiuz

et al. 2021

Sci Rep

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“…Although the antibiotic agent in the extender was effective against the bacterial load in semen doses, this interaction may indicate that the initial contamination might have influenced the storage environment. We speculate that initial bacterial contamination, even if controlled with antibiotics, can play a role in sperm viability during storage due to the bacteria-secreted toxins and metabolites or by direct attachment of bacteria on the sperm cells and subsequent activation of signalling pathways related to oxidative stress, and apoptosis (Oghbaei et al, 2020). It is also important to emphasize that sperm motility had a slight decrease, but this effect may not be biologically relevant.…”

Section: Discussionmentioning

confidence: 94%

Adjusted method of penis fixation during boar semi‐automatic semen collection aiming to reduce bacterial contamination

Paschoal

Mellagi

Ferrari³

et al. 2021

Reprod Domestic Animals

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Boar ejaculates usually contain bacteria due to contamination during semen collection (Althouse & Lu, 2005;Goldberg et al., 2013) that may impair in vitro quality (motility, agglutination, membrane integrity), and fertility (Martín et al., 2010); therefore, antimicrobials are standard components in semen extenders (Knox, 2016). In this sense, some efforts have been developed to determine critical factors for contamination to reduce bacterial load in extended boar semen

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“…The effect of bacterial infection on reproductive system function is important. Various bacteria have been isolated and identified from the male reproductive system, including Escherichia coli , Staphylococcus aureus , Ureaplasma urealyticum , C. trachomatis , N. gonorrhoeae , Streptococcus agalactia , and Staphylococcus saprophyticus ( Oghbaei et al, 2020 ). These bacteria lead to all kinds of diseases, such as chlamydiosis, gonorrhea, and ureaplasmosis, which can cause male reproductive system infections ( Trojian et al, 2009 ).…”

Section: Male Infertility and Bacterial Infectionsmentioning

confidence: 99%

Bacterial Infections Affect Male Fertility: A Focus on the Oxidative Stress-Autophagy Axis

Wang

Zhang

Yao

et al. 2021

Front. Cell Dev. Biol.

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Numerous factors trigger male infertility, including lifestyle, the environment, health, medical resources and pathogenic microorganism infections. Bacterial infections of the male reproductive system can cause various reproductive diseases. Several male reproductive organs, such as the testicles, have unique immune functions that protect the germ cells from damage. In the reproductive system, immune cells can recognize the pathogen-associated molecular patterns carried by pathogenic microorganisms and activate the host’s innate immune response. Furthermore, bacterial infections can lead to oxidative stress through multiple signaling pathways. Many studies have revealed that oxidative stress serves dual functions: moderate oxidative stress can help clear the invaders and maintain sperm motility, but excessive oxidative stress will induce host damage. Additionally, oxidative stress is always accompanied by autophagy which can also help maintain host homeostasis. Male reproductive system homeostasis disequilibrium can cause inflammation of the genitourinary system, influence spermatogenesis, and even lead to infertility. Here, we focus on the effect of oxidative stress and autophagy on bacterial infection in the male reproductive system, and we also explore the crosslink between oxidative stress and autophagy during this process.

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Effects of bacteria on male fertility: Spermatogenesis and sperm function

Cited by 25 publications

References 150 publications

Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions

Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions

Adjusted method of penis fixation during boar semi‐automatic semen collection aiming to reduce bacterial contamination

Bacterial Infections Affect Male Fertility: A Focus on the Oxidative Stress-Autophagy Axis

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