Effects of avermectin on immune function and oxidative stress in the pigeon spleen

Liu, Ci; Li, Ming; Cao, Yangsen; Qu, Jianping; Zhang, Ziwei; Xu, Shiwen; Li, Shu

doi:10.1016/j.cbi.2013.12.015

Cited by 56 publications

(29 citation statements)

References 49 publications

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“…We observed that IFN-γ was lower in the chicken bursa of Fabricius. Our results are consistent with those reported by Liu et al, who showed that IFN-γ was lower in the spleen of pigeons exposed to avermectin (Liu et al 2014a). Another study showed that the downregulation of IFN-γ causes a decrease in the immune function of chickens (Fleshner et al 1998).…”

Section: Discussionsupporting

confidence: 93%

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Khoso

Yang

Liu

et al. 2015

Cell Stress and Chaperones

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Selenium (Se) is necessary for the immune system in chicken and mediates its physiological functions through selenoproteins. Heat shock proteins (Hsps) are indispensable for maintaining normal cell function and for directing the immune response. The aim of the present study was to investigate the effects of Se deficiency on the messenger ribonucleic acid (mRNA) expression levels of selenoproteins and Hsps as well as immune functions in the chicken bursa of Fabricius. Two groups of chickens, namely the control and Se-deficient (L group) groups, were reared for 55 days. The chickens were offered a basal diet, which contained 0.15 mg Se/kg in the diet fed to the control group and 0.033 mg Se/kg in the diet fed to the L group. We performed real-time quantitative polymerase chain reactionto detect the mRNA expression levels of selenoproteins and Hsps on days 15, 25, 35, 45 and 55. Western blotting was used to determine the protein expression levels of Hsps on days 35, 45 and 55, and immune functions were assessed through an enzyme-linked immunosorbent assay on days 15, 35, and 55. The data showed that the mRNA expression levels of selenoproteins, such as Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, GPx1, GPx2, GPx3 GPx4, Sepp1, Selo, Sel-15, Sepx1, Sels, Seli, Selu, Selh, and SPS2, were significantly lower (P<0.05) in the L group compared with the control group. Additionally, the mRNA and protein expression levels of Hsps (Hsp27, Hsp40, Hsp60, Hsp70, and Hsp90) were also significantly higher (P<0.05) in the L group. The expression levels of IL-2, IL-6, IL-8, IL-10, IL-17, IL-1β, IFN-α, IFN-β, and IFN-γ were significantly lower (P<0.05) and TNF-α was significantly higher (P<0.05) in the L group compared with the control group. Our results show that immunosuppression was accompanied by a downregulation of mRNA expression levels of selenoproteins and an upregulation of the Hsp mRNA expression levels. Thus, Se deficiency causes defects in the chicken bursa of Fabricius, and selenoproteins and Hsps play important roles in immunosuppression in the bursa of Fabricius of chickens with Se deficiency.

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Section: Discussionsupporting

confidence: 93%

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Khoso

Yang

Liu

et al. 2015

Cell Stress and Chaperones

Self Cite

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“…Moreover, these discrepancies might also be caused by the fish species, age, physiological status, and different laboratory conditions, such as the temperature and water quality. IFN-c is a pleiotropic pro-inflammatory and antiviral cytokine, and it can rapidly activate host macrophages, resulting in enhancement of the immune response (Nakamura et al, 1984;Liu et al, 2014). Moreover, it plays an important role in regulating immune responses and inhibiting cellular proliferation as well as in repressing tumor growth (Schroder et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Alteration in the cytokine levels and histopathological damage in common carp induced by glyphosate

2015

Chemosphere

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“…Pro-inflammatory cytokines allow organisms to respond to infectious agents and induce inflammation; over-production of these agents can occur as well, leading to chronic inflammation and/or autoimmunity [51,52]. While the immune system and its cells have mechanisms to inhibit the inflammation induced by these cytokines [53], changes in levels of these proteins can serve as an indirect index to assess immune function status [54].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

Hassan¹

2014

J Cytol Histol

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Citation: Hassan ZA, Arafa MH, Soliman WI, Atteia HH, Al-Saeed HF (2014) The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study). AbstractMonosodium glutamate (MSG), a flavor enhancer, is used in modern nutrition to improve food palatability.The objectives of the current study were to investigate the effect of MSG on thymus as well as spleen structures and functions. Also, to evaluate the possibility of recovery after cessation of administration. Adult male rats were divided into three groups: control, MSG (3 g MSG/kg body weight daily for 8 weeks by oral gavages), and Recovery (MSG for same period and then left untreated for additional 4 weeks). The results showed that MSG treatments significantly increased serum interleukin (IL)-1β as well as thymic and splenic malondialdehyde and decreased serum levels of IL-10 and also reduced glutathione (GSH) levels and both catalase and superoxide dismutase activities in the thymus and spleen. Histological examination showed that MSG induced a remarkable disruption in the lobular architecture of the thymus with marked decrease of the T lymphocytes with darkly stained nuclei and dilated blood sinusoid in the cortical region. Medullary region were enlarged and repopulated with small lymphocytes and dilated blood sinusoids. The cortical-medullary differentiation was difficult to be determined. Small sized splenic lymphatic follicles with absence of germinal centers and large congested blood vessels were also noticed. The differentiation between the red and the white pulps was indistinct. Recovery groups showed preserved thymic lobular architecture with repopulation of the cortical thymocytes enclosing the paler staining medulla .Splenic lymphatic follicles of different sizes with absence of germinal centers were noticed. Marginal zone is differentiated from the red pulp. Immunohistochemical staining of MSG group demonstrated a marked decrease in CD3-positive T-lymphocytes in both thymus and spleen that significantly increased in recovery group. Taken together, the data showed that MSG consumption may have immunotoxic effects on the thymus and spleen of adult rats which is reversible but the normal structure of the spleen would need time to be regained. It is recommended that further studies aimed at corroborating these findings be carried out.

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Effects of avermectin on immune function and oxidative stress in the pigeon spleen

Cited by 56 publications

References 49 publications

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Alteration in the cytokine levels and histopathological damage in common carp induced by glyphosate

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

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