Effects of Autoantibodies on the Course of Pregnancy and Fetal Growth

Iijima, Takashi; Tada, Hayato; Hidaka, Yoh; Mitsuda, Nobuaki; Murata, Yuji; Amino, Nobuyuki

doi:10.1016/s0029-7844(97)00283-4

Cited by 127 publications

(89 citation statements)

References 26 publications

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“…However, the negative results may be skewed by the fact that the analysis was performed only in positively screened women. Nevertheless, some other previous studies also didn't find any link between TPOAb titers and obstetric complications [23,28].…”

Section: Discussionmentioning

confidence: 70%

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Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

et al. 2011

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Section: Discussionmentioning

confidence: 70%

“…The rate of PTD varied from 4 to 26.8 % in TPOAb-positive women and 3-8.2 % in TPOAbnegative controls [22,23,24,25]. The causality of this…”

Section: Discussionmentioning

confidence: 92%

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

et al. 2011

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“…Negro et al demonstrated that T 4 treatment in women with TAI significantly decreased the number of miscarriages (94,119). In a Japanese study (120) in which seven different types of autoantibodies were evaluated, excluding anticardiolipin, a similar prevalence of prematurity was observed in the control group compared with women with at least one positive antibody. A review (121) indicates that, besides antiphospholipid antibodies, the presence of other autoantibodies is also associated with recurrent pregnancy loss.…”

Section: European Journal Of Endocrinologymentioning

confidence: 91%

CONTROVERSIES IN ENDOCRINOLOGY: On the need for universal thyroid screening in pregnant women

Vila

Velasco

González

et al. 2014

European Journal of Endocrinology

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There is a well-known controversy among scientific societies regarding the recommendation to screen for thyroid dysfunction (TD) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive effects of thyroxine (T 4 ) treatment in such cases. Despite the scarcity of this evidence, there is a widespread agreement among clinicians on the need for treatment of clinical hypothyroidism during pregnancy and the risks that could arise due to therapeutic abstention. As maternal TD is a quite prevalent condition, easily diagnosed and for which an effective and safe treatment is available, some scientific societies have proposed to assess thyroid function during the first trimester of pregnancy and ideally before week 10 of gestational age. Given the physiologic changes of thyroid function during pregnancy, hormone assessment should be performed using trimester-specific reference values ideally based on locally generated data as geographic variations have been detected. Screening of TD should be based on an initial determination of TSH performed early during the first trimester and only if abnormal should it be followed by either a free or total T 4 measurement. Furthermore, adequate iodine supplementation during pregnancy is critical and if feasible it should be initiated before the woman attempts to conceive.

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“…The studies differed in various aspects. Some had followed a cohort (235)(236)(237)248,250,252,253,(260)(261)(262)(263)(264)(265)(266)(267)(268)(269)(270)(271) (B,A,B,B,B,B,B,A,B-B) and others were "case-controlled" studies (251,254,(272)(273)(274)(275) (C,C,C,C,C).…”

Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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Effects of Autoantibodies on the Course of Pregnancy and Fetal Growth

Abstract: Antithyroid microsomal antibody and antinuclear antibody are the only autoantibodies that increase the abortion rate.

Cited by 127 publications

References 26 publications

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

CONTROVERSIES IN ENDOCRINOLOGY: On the need for universal thyroid screening in pregnant women

Clinical practice guidelines for the management of hypothyroidism

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