Effects of atriopeptin infusion versus effects of left atrial stretch in awake dogs

Goetz, K. L.; Wang, B. C.; Geer, P. G.; Sundet, W. D.; Needleman, Philip

doi:10.1152/ajpregu.1986.250.2.r221

Cited by 24 publications

(11 citation statements)

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“…Therefore, we conclude that increase in the circulating plasma volume is an important factor in controlling hANP release, but that elevation of the serum sodium concentra¬ tion, like increase in the plasma osmolality, is not essential for stimulating hANP release in the physiological state. The infusion of atriopeptin at a rate of 3 µg·kg"1·min"1 caused a significant increase in the urinary output and sodium excretion in conscious dogs (Goetz et al 1986a). An intravenous bolus injection of 100 µg of hANP induced a four-fold increase in urinary sodium excretion and a two¬ fold increase in the urinary volume in men (Ri¬ chards et al 1985).…”

Section: Discussionmentioning

confidence: 99%

Effects of an oral water load and intravenous administration of isotonic glucose, hypertonic saline, mannitol and furosemide on the release of atrial natriuretic peptide in men

Yamasaki

Nishiuchi²,

Kojima³

et al. 1988

Acta Endocrinologica

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The effects of an oral water load and iv administration of isotonic glucose, hypertonic saline, mannitol and furosemide on release of human atrial natriuretic peptide (hANP) were examined in normal subjects to determine the main factors causing its release. In addition, the influence of age on hANP secretion was investigated. The mean plasma hANP level in normal subjects, 0\p=n-\89 years old, was 20.6 \m=+-\1.1 ng/l (mean \m=+-\sem) and showed age-related change. The plasma hANP level did not change significantly after a water load or infusion of isotonic glucose, but rose significantly from 11.4 \m=+-\1.4 to 15.6 \m=+-\3.2 ng/l after infusion of hypertonic saline and from 10.9 \m=+-\1.6 to 17.8 \m=+-\ 4.1 ng/l after infusion of 20% mannitol in parallel with the increase in plasma volume. The plasma hANP level decreased from 17.3 \ m=+-\2.5 to 9.0 \ m=+-\2.5 ng/l after injection of 40 mg of furosemide. A positive correlation was found between change in the plasma hANP level and percent change in the plasma volume (P < 0.001) on these treatments. The response of plasma hANP to hypertonic saline infusion was greater in older than in young men. These results indicate that 1) the secretion of hANP shows an age-related change and 2) increase in the circulating plasma volume is an important factor regulating hANP secretion.-, ß-and -human atrial natriuretic peptides (h AN ) were first isolated from human atria by Kangawa and coworkers (Kangawa & Matsuo 1984; Kangawa et al. 1985). -hANP, consisting of 28 amino acids, has been shown to have potent diuretic, natriuretic and vasorelaxant actions in man (Richards et al. 1985). Radioimmunoassays of plasma hANP have been developed by several groups including us (Nishiuchi et al. 1986) and used to measure the plasma hANP concentrations in normal subjects and patients with various di¬ seases (Hasegawa et al. 1986;Tikkanen et al. 1985). We previously reported that patients with congestive heart failure, renal failure and liver cirrhosis had higher concentrations of plasma hANP than normal subjects (Nishiuchi et al. 1986). It was also reported that hANP is secreted in response to volume expansion owing to isotonic saline infusion (Ogihara et al. 1986), but that other factors regulating ANP secretion were not fully known. There are some reports on the relation between age and plasma hANP concen¬ tration, in children (Weil et al. 1986) and in adults (Ohashi et al. 1987a,b). Therefore, in this work we examined the effects of plasma volume, plasma osmolality and serum sodium concentration on hANP secretion in normal subjects by measuring the plasma hANP concentration after intravenous infusion of isotonic glucose, hypertonic saline or mannitol and after a bolus injection of furosemide. In addition, we measured the plasma levels of hANP in young and older men in the basal state and after infusion of hypertonic saline.

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Section: Discussionmentioning

confidence: 99%

Effects of an oral water load and intravenous administration of isotonic glucose, hypertonic saline, mannitol and furosemide on the release of atrial natriuretic peptide in men

Yamasaki

Nishiuchi²,

Kojima³

et al. 1988

Acta Endocrinologica

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“…Numerous previous studies have demonstrated that the decrease in arterial blood pressure elicited by the administration of ANP is not accompanied by a reflex tachycardia (Baum et al, 1986;Goetz et al, 1986;Bie et al, 1988;Ebert et al, 1988;Lambert et al, 1994). These results form the basis of a first hypothesis that ANP interferes with the baroreflex control of the circulation via the autonomic nervous system.…”

Section: Discussionmentioning

confidence: 56%

Direct chronotropic effects of atrial and C‐type natriuretic peptides in anaesthetized dogs

Beaulieu¹,

Cardinal²,

Léan³

et al. 1996

British J Pharmacology

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1 The chronotropic effects of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) were investigated using injections (50 Mg in 1 ml of Tyrode solution as bolus over 1 min) directly into the sinus node artery of 21 anaesthetized and vagotomized dogs which had been pretreated with a f,-adrenoceptor antagonist. The injections were also repeated following: (a) a-adrenoceptor antagonism (prazosin) and muscarinic receptor antagonism (atropine); (b) inhibition of prostaglandin synthesis (indomethacin); (c) angiotensin II AT1 receptor antagonism (losartan); (d) histamine HI (mepyramine) and H2 (cimetidine) receptor antagonism. 2 The results obtained indicate that ANP had no significant effect on the basal sinus rate, whereas CNP produced a slight but significant increase of 12+2 beats min-'. The effect of CNP was long-lasting (return to pre-injection levels after maximum effect in 17+3 min) and was not influenced by the various antagonists mentioned above. 3 During in vitro experiments on spontaneously beating right atria isolated from 6 dogs, the injection of CNP (50 pg in 1 ml of Tyrode solution) into the sinus node artery produced an increase in atrial rate of 14+1 beats min-'. 4 The results of this work indicate that CNP exerts a significant and prolonged positive chronotropic effect both in vivo and in vitro. Other studies are required to elucidate the mechanism of action of CNP on the heart conduction system, to ascertain the presence of natriuretic peptide receptor B in the region of the sinoatrial node and to determine the role of CNP in the control of heart rate.

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“…However, some peptides, such as atrial natri uretic factor, are also vasorelaxants [11,12], but reduce ABP by lowering CO [13,14] not through peripheral vasodilation. In our study, because of the reduction in TPRI and the increase in Cl, the increase in ABP was con sidered to be mediated, at least in part, by the increase of the Cl not through the increase in peripheral vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Effects of Centrally Administered Adrenomedullin (13–52) in Anesthetized Rats

Wei

Tian

et al. 1995

Neurosignals

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This study was conducted to investigate the effect of intracerebroventricular administration of adrenomedullin (13–52) [ADM(13–52)], a novel hypotensive peptide, on the hemodynamic parameters of anesthetized rats. ADM(13–52) was administered centrally in a dose of 0.4–3.2 nmol/kg. It provoked marked, prolonged and dose-dependent increases in mean arterial blood pressure, heart rate, stroke volume, cardiac index, left ventricular pressure, left ventricular dp/dt_maxand dp/dt_min, but reduction in total peripheral resistance index. In addition, intracerebroventricular administration of ADM(13–52; 1.6 nmol/kg) provoked a marked increase in renal sympathetic nerve activity. Intracerebroventricular administration of artificial cerebrospinal fluid had no effect on the hemodynamic parameters and renal sympathetic nerve activity. The results indicate that ADM(13–52) exerts a central action on the cardiovascular system. The mechanisms of hemodynamic changes induced by central ADM(13–52) were preliminarily analyzed in this study. ADM might play a role in the central control of the cardiovascular system, although the confirmed mechanisms and the physiological implications are undetermined.

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Effects of atriopeptin infusion versus effects of left atrial stretch in awake dogs

Cited by 24 publications

References 0 publications

Effects of an oral water load and intravenous administration of isotonic glucose, hypertonic saline, mannitol and furosemide on the release of atrial natriuretic peptide in men

Effects of an oral water load and intravenous administration of isotonic glucose, hypertonic saline, mannitol and furosemide on the release of atrial natriuretic peptide in men

Direct chronotropic effects of atrial and C‐type natriuretic peptides in anaesthetized dogs

Hemodynamic Effects of Centrally Administered Adrenomedullin (13–52) in Anesthetized Rats

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