Effects of atrazine on the gill cells and ionic balance in a neotropical fish, Prochilodus lineatus

Paulino, Marcelo Gustavo; Sakuragui, Marise Margareth; Fernandes, Marisa N.

doi:10.1016/j.chemosphere.2011.08.033

Cited by 59 publications

(25 citation statements)

References 27 publications

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“…In our case, the supply of HCO 3 − decreased with H + excretion (35). Accordingly, we can say that chlorpyrifos inhibited the enzyme at very low concentrations due to the electronegative atoms in the pesticide's chemical structures (9).…”

Section: +mentioning

confidence: 82%

In vivo changes in carbonic anhydrase activity and histopathology of gill and liver tissues after acute exposure to chlorpyrifos in rainbow trout

Topal¹,

Atamanalp²,

Oruç³

et al. 2014

Archives of Industrial Hygiene and Toxicology

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Chlorpyrifos is an organophosphate pesticide widely used in agriculture and aquaculture. This study investigated its effects on carbonic anhydrase (CA) enzyme activity and histopathology of rainbow trout gill and liver. The fish were exposed to 2.25 (25 % of 96 h LC 50 ), 4.5 (50 % of 96 h LC 50 ), and 6.75 µg L -1 (75 % of 96 h LC 50 ) of chlorpyrifos for 24, 48, 72, and 96 h. CA activity was measured in liver and gills and histopathological changes were examined by light microscopy. The most common liver changes at most of the chlorpyrifos concentrations were hyperaemia and degenerative changes. Gill tissues were characterised by lamellar hyperaemia, lamellar oedemas, clumping, cellular degeneration, hyperplasia, and lamellar atrophy. CA enzyme activity in the gills decreased at all concentrations at 48, 72, and 96 h after exposure to chlorpyrifos (p<0.05). Similarly, there was a time-dependent decrease in CA activity at all of the concentrations in liver tissues (p<0.05). The present study indicated that chlorpyrifos inhibits CA enzyme activity and causes histopathological damage in gill and liver tissues.

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Section: +mentioning

confidence: 82%

In vivo changes in carbonic anhydrase activity and histopathology of gill and liver tissues after acute exposure to chlorpyrifos in rainbow trout

Topal¹,

Atamanalp²,

Oruç³

et al. 2014

Archives of Industrial Hygiene and Toxicology

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show abstract

“…The most logical reason for the larger surface area of the ionocytes in the atrazineexposed group would be hypertrophy of these cells which we observed in our histo pathological study of the gills. Edema in gill ionocytes has also been reported as one of the effects of atrazine in Prochilodus lineatus (Paulino et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Histopathological effects of atrazine on gills of Caspian kutum Rutilus frisii kutum fingerlings

Khoshnood¹,

Jamili²,

Khodabandeh³

2015

Dis. Aquat. Org.

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The use of chemical pesticides has increased environmental pollution and affects fishes as non-target organisms. To investigate the toxic effects of the widely used herbicide atrazine on Caspian kutum Rutilus frisii kutum fingerlings, fish were exposed to a sublethal concentration of half LC 50 for 96 h. The main alterations visible in the gill tissue were detachment of the epithelium of the lamellae, necrosis, lamellar fusion, hyperplasia, club shaped lamellae, collapse of the lamellae, shrinkage and curling of the lamellae, and ultrastructural alterations such as necrosis of the apical microridges of the pavement cells. Results also showed that the gill ionocytes were fewer in number and larger in size in the atrazine-exposed fish. Atrazine appears to be highly toxic to Caspian kutum fingerlings even at a sublethal concentration (12.47 mg l

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“…In addition, ATPases are a group of membrane-bound enzymes responsible for transporting the cations across the cell membrane, maintaining intracellular functions [37, 38]. Although it is reported the effects of atrazine on ionic disorder and ATPases disturbance in mice, the data concerning the birds were limited.…”

Section: Introductionmentioning

confidence: 99%

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

Lin

Qin

et al. 2016

Oncotarget

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The widely used atrazine has been reported to exhibit extensive ecological hazards. Due to the biological accumulation, atrazine elicits widespread toxic effects on different organisms. However, true proof for the mechanism of atrazine-induced toxicity is lacking. To determine the potential mechanism by which atrazine exerted toxic effects, quails were treated with atrazine (0, 50, 250 and 500 mg/kg) by gavage administration for 45 days. Atrazine significantly increased the histological alterations and serum creatine kinase, lactate dehydrogenase and choline esterase levels. A marked disorder in ionic (Na+, K+, Ca2+ and Mg2+)contents and the decrease of ATPases (Na+-K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and Ca2+-Mg2+-ATPase) activities were observed in the heart and liver of atrazine-exposed quails. Of note, it was also observed that atrazine suppressed the transcription of Na+, K+ transfer associated genes (Na+-K+-ATPase subunits) and Ca2+ transfer associated genes (Ca2+-ATPase subunits, solute carriers) in heart and liver. In conclusion, atrazine induced cardiac and hepatic damage via causing the ionic disorder, triggering the transcription of the ion transporters and leading the histopathological and functional alternations in the heart and liver of quails. This study demonstrated atrazine significantly induced the ionic disorder via decreasing the ATPases activities and disturbing the transcription of the ion transporters.

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Effects of atrazine on the gill cells and ionic balance in a neotropical fish, Prochilodus lineatus

Cited by 59 publications

References 27 publications

In vivo changes in carbonic anhydrase activity and histopathology of gill and liver tissues after acute exposure to chlorpyrifos in rainbow trout

In vivo changes in carbonic anhydrase activity and histopathology of gill and liver tissues after acute exposure to chlorpyrifos in rainbow trout

Histopathological effects of atrazine on gills of Caspian kutum Rutilus frisii kutum fingerlings

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

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