Effects of atrazine and chlorpyrifos on the mRNA levels of HSP70 and HSC70 in the liver, brain, kidney and gill of common carp (Cyprinus carpio L.)

Xing, Houjuan; Li, Shu; Wang, Xu; Gao, Xuejiao; Xu, Shiwen; Wang, Xiaolong

doi:10.1016/j.chemosphere.2012.06.028

Cited by 76 publications

(29 citation statements)

References 46 publications

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“…Chen et al reported that the mRNA expression of Hsp90 was inhibited by Cd [40]. Liu et al reported that high dose pesticide exposure curtailed protein synthesis [41]. Our results suggested that with chronic exposure to As 2 O 3 for 30 to 90 days, Hsp90 expression in the immune organs of the L, M and H groups increased compared with the C group in a dose-dependent manner (Fig.…”

Section: Discussionsupporting

confidence: 54%

Effects of Arsenic Trioxide Exposure on Heat Shock Protein Response in the Immune Organs of Chickens

Guo

Zhao

Guo

et al. 2015

Biol Trace Elem Res

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Arsenic trioxide (As2O3), a kind of pentavalent arsenic, has recently been linked to disrupted immune function. Heat shock proteins (Hsps), a group of highly conserved proteins, are rapidly synthesised when living organisms are exposed to various stress conditions. The objective of this study is to determine the effects of As2O3 on the expression level of Hsps (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27) in the immune organs (spleen, thymus and bursa of Fabricius (BF)) of chickens. A total of 72 1-day-old male Hy-line chickens were randomly divided into four groups, including the low-As group (L group), middle-As group (M group), high-As group (H group) and control group (C group). Immune organs were collected, and levels of Hsp messenger RNA (mRNA) and protein were examined on days 30, 60 and 90. The results showed that the levels of Hsp mRNA (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27) and protein (Hsp70 and Hsp60) expression were significantly increased (p < 0.05 or p < 0.01) in the As2O3 treatment groups compared with the corresponding control groups. Taken together, these results suggest that As2O3 influences the level of Hsps in immune organs.

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Section: Discussionsupporting

confidence: 54%

Effects of Arsenic Trioxide Exposure on Heat Shock Protein Response in the Immune Organs of Chickens

Guo

Zhao

Guo

et al. 2015

Biol Trace Elem Res

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“…However, in the present study a decrease in the hsp70 expression levels was found. Although this may seem contradictory, expression levels of hsp70 were also reported to be lower in other studies, including in Salvelinus alpinus (Aluru et al, 2004), Cyprinus carpio (Xing et al, 2013), and Salmo salar (Olsvik et al, 2014). Differences in the species, exposure protocol, concentration, sampling timing, and methodology might all account for the disparate results both for hsp70 and brain StAR protein expression levels.…”

Section: Discussionmentioning

confidence: 66%

Impaired brain StAR andHSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide

Rosa

Koakoski

Piato

et al. 2015

Journal of Toxicology and Environmental Health, Part A

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Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression. Data demonstrated that MPBI produced a decrease brain StAR and hsp70 gene expression.

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“…This pattern of effects is just the opposite to the observed decrease in IL-6 secretion ( Figure 51.2), indicating that stress response at the HSP level does not result in increased IL-6 secretion. Increase in HSP70 was also demonstrated in several organs of common carp exposed to chlorpyrifos (Xing et al, 2013), suggesting a conservative mechanism unrelated to specific species, tissue, or OP. From the standpoint of muscle regeneration, it remains to be investigated whether the observed HSP response to DFP in any way protects proliferative potential of myoblasts that may be hampered by DFP-induced decrease in IL-6 secretion.…”

Section: Heat Shock Proteins In Human Myoblasts and Myotubes After Trmentioning

confidence: 80%

The Effects of Organophosphates in the Early Stages of Human Muscle Regeneration

Marš¹,

Miš²,

Pirkmajer³

et al. 2015

Handbook of Toxicology of Chemical Warfare Agents

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Effects of atrazine and chlorpyrifos on the mRNA levels of HSP70 and HSC70 in the liver, brain, kidney and gill of common carp (Cyprinus carpio L.)

Cited by 76 publications

References 46 publications

Effects of Arsenic Trioxide Exposure on Heat Shock Protein Response in the Immune Organs of Chickens

Effects of Arsenic Trioxide Exposure on Heat Shock Protein Response in the Immune Organs of Chickens

Impaired brain StAR andHSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide

The Effects of Organophosphates in the Early Stages of Human Muscle Regeneration

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