Effects of Atorvastatin Therapy on the Low-Density Lipoprotein Subfraction, Remnant-Like Particles Cholesterol, and Oxidized Low-Density Lipoprotein Within 2 Weeks in Hypercholesterolemic Patients

Short-term effects of low-dose atorvastatin on inflammatory status and lipid profiles in perimenopausal hypercholesterolemic, hypertriglyceridemic women

“…However, there was no correlation between the pleiotropic effects and the improvement of lipid profiles except for positive correlation between the inhibition in the coagulation activity (PAI-1 / t-PA ratio) and the improvement in the TG and RLP-C levels. Previous studies indicate that several statin-induced pleiotropic effects are lipid-independent, which is in keeping with our results [28,42,43]. The precise mechanism responsible for the beneficial effect of atorvastatin on coagulation activity is controversial.…”

Comparisons of short- and intermediate-term effects of pitavastatin versus atorvastatin on lipid profiles, fibrinolytic parameter, and endothelial function

“…Enrollment criteria included a low-density lipoprotein (LDL) cholesterol concentration N160 mg/dl and a triglyceride concentration b400 mg/dl while following the diet therapy [2,3]. Patients who smoked or had diabetes, hypertension, vascular events, revascularization procedures, coronary artery disease, or active liver disease, or took any concomitant drug, were excluded [2,3].…”

“…At baseline and after 2 weeks and 3 months of therapy, we measured lipid concentrations (total cholesterol, triglyceride, LDL-cholesterol, and high-density lipoprotein cholesterol) and fibrinolytic parameter (plasminogen activator inhibitor type 1) after more than 12 h of fasting, and also assessed endothelial function ultrasonographically by endothelium-dependent and -independent vasodilation of the brachial artery (flowmediated vasodilation and nitroglycerin-induced vasodilation, respectively), as described previously [2,3]. In addition, 30 healthy volunteers were examined as a control group.…”

The Clinical Relevance of Low-Density-Lipoproteins Size Modulation by Statins

“…Treatment with atorvastatin resulted more frequently in a beneficial effect (nineteen studies) [26,30,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] than not (eleven studies) [36,46,[71][72][73][74][75][76][77][78][79] and this has been confirmed at different doses and in a wide-range of different categories of patients: with hypercholesterolaemia [60,63,64,70], with hypertriglyceridemia [65], with combined [30,55,56,58,59,67,69] or familial combined hyperlipidemia [26], with familial hypercholesterolemia [54,61], with type 1 [68] and 2 diabetes [57,58,…”