Effects of Atorvastatin on Vascular Intimal Hyperplasia: An Experimental Rodent Model

Abstract

Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation.

A systematic review and meta-analysis on the effect of statins on plasma asymmetric dimethylarginine concentrations

“…Since both ROS and systemic inflammation are responsible for increased ADMA levels, and statins are recognized as anti-inflammatory and antioxidant agents 41 , the hypothesis was that statin therapy might decrease ADMA levels. Indeed, several smaller studies have shown that statin therapy reduces ADMA levels 25,42 , however other studies with high dose statins (e.g.…”

Metabolic syndrome and renal disease

“…It has also been demonstrated that statins exert significant BP-lowering effects, particularly on systolic BP [161,[163][164][165]. Furthermore, animal models revealed that statins decrease the severity of lipid-induced glomerular damage and thus preserve renal function [110,[166][167][168]. In humans, statins may have a favorable impact on the slowing of CKD progression, since it was proved that they significantly decrease proteinuria [169,170].…”

Nephroprotective and clinical potential of statins in dialyzed patients

“…Controlled and randomized clinical trials do not definitively support the clinical efficacy of statins in CKD and HD patients. Laboratory data also provide evidence for the biochemical and anti-inflammatory benefit of statins that should not be ignored despite the lack of comprehensive clinical evidence [85][86][87]. Nevertheless, the routine use of statins in this population remains the decision of individual physicians in discussion with their patients.…”