Effects of atorvastatin on circulating CD34+/CD133+/ CD45− progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitus

Abstract

Abstract. Jaumdally RJ, Goon PKY, Varma C, Blann AD, Lip GYH (City Hospital, Birmingham, United Kingdom). Effects of atorvastatin on circulating CD34+ ⁄ CD133+ ⁄ CD45) progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitus. J Intern Med 2010; 267: 385-393.

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

“…In addition to their lipid-lowering effect, statins have many pleiotropic effects that may explain their cardiovascular benefit. Both experimental 81,82 and clinical studies 83 demonstrate that statins increase the number and function of circulating EPCs by increasing the bioavailability of NO and reducing oxidative stress and apoptosis of EPCs. Blockade of the renin-angiotensin system with angiotensinconverting enzyme inhibitors or angiotensin receptor blockers has also been shown to increase EPC number in patients with DM, 84,85 possibly mediated by their anti-inflammatory and antioxidative actions through the suppression of angiotensin II.…”

Statins in Low Doses Reduce VEGF and bFGF Serum Levels in Patients with Type 2 Diabetes Mellitus

“…It was demonstrated that angiogenesis is also modified by diabetes-related mechanisms [20,21,22], but there are only a few studies analyzing the serum levels of angiogenesis-promoting factors among patients with type 2 diabetes treated with statins [23,24]. Moreover, most clinical studies concern statins given at high doses (e.g.…”

Endothelial Progenitor Cell Number: A Convergence of Cardiovascular Risk Factors

“…LDL-C is inversely correlated with EPC number and function in human patients (Chen, Zhang et al 2004). Statin therapy has been shown to increase EPC numbers and function (Fadini, Albiero et al 2010;Jaumdally, Goon et al 2010) and to enhance EPC numbers in response to ischemic stimuli (Spadaccio, Pollari et al 2010;Hibbert, Ma et al 2011). The improvement of endothelial function associated with statin use is directly correlated with the increase in EPC numbers and measures of EPC function (Higashi, Matsuoka et al 2010).…”