Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review

Abstract

Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes.

Effects of cold atmospheric gas phase plasma on anthocyanins and color in pomegranate juice

“…That results with adiabatic system with high content of kinetic energy at lower temperatures (<70°C) (Schluter, Ehlbeck, Hertel, Habermeyer, Roth, Engel, et al, 2013). Furthermore, cold plasma emits highly energetic and charged particles (electrons, positive and negative ions), radicals, neutral species (excited atoms and molecules) and photons (visible and UV), able to break down covalent bonds and initiate numerous chemical reactions with significant importance for various technological application (Arjunan, Sharma, & Ptasinska, 2015;Song, Kim, Choe, Jung, Moon, Choe, et al, 2009). Otherwise stated, plasma is partially ionized gas where its temperature is determined by thermally inefficient interaction of gas ions/neutrals with walls (energized electrons have low heat capacity) that will generally yield lower temperatures for the entire system with substantial content of kinetic energy (Butz & Tauscher, 2002).…”

Mechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation

“…The effects of plasma radiation on DNA alteration and the mechanisms of the ensuing damage repair processes need to be investigated comprehensively because control of plasma-mediated DNA damage is crucial both for the optimization of cancer therapy or bactericidal activity in some applications and for the avoidance of chromosomal damage in others such as the wound healing process (Arjunan et al 2015). Moreover, it is not yet clear whether ROS generated by plasma treatment are crucial for apoptosis and its associated DNA fragmentation or whether plasma-induced direct DNA damage provokes cell cycle checkpoint signaling that leads to apoptosis.…”

Atmospheric cold plasma interactions with modified atmosphere packaging inducer gases for safe food preservation

“…By comparison with the strong sterilization effect of ROS, the cellular damage with RNS was 339 reported in conjunction with ROS or by inducing oxidative stress (Boxhammer, et al, 2012;340 Sakudo, et al, 2014 and alkylperoxynitrite (ROONO) (Arjunan, et al, 2015;Graves, 2012). The main RNS for …”