Effects of Atherosclerosis on the Cutaneous Regional and Microcirculatory Response to Ischemia

Schwartz, Richard W.; Qing-Fu, Hu; Logan, Nancy M.; Richardson, Daniel R.; Hyde, Gordon L.

doi:10.1001/archsurg.1990.01410160071015

“…The cause of this intermittency is called vasomotion, which is controlled by the precapillary sphincters [8], It has been indicated that both myogenic and metabolic fac tors are involved in the regulation of cutaneous capillary blood flow following arterial occlusion. The hyperemic response after 1 min occlusion is largely of myogenic ori gin; metabolic factors are probably responsible for the prolonged hyperemia seen with longer durations of occlu sion [17]. The most important factor found thus far affect ing the precapillary sphincter is the concentration of oxy gen in the tissue [8].…”

Section: Morphology a Nalysismentioning

confidence: 99%

Study of Dynamic Microcirculatory Problems in 'Blackfoot Disease' - Emphasizing Its Differences from Arteriosclerosis

Yu¹,

Chang²,

Chen³

et al. 1995

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The cutaneous microcirculation can be divided into thermoregulatory shunt vessels and nutritive skin capillaries. Flux in nonnutritional shunt vessels dominates the signal recorded by the laser Doppler flowmeter. Computerized videophotometric capillaroscopy is a sensitive method for assessing cutaneous nutritive microcirculation. Using patients with blackfoot disease and arteriosclerosis as disease models, we evaluated the sensitivity and clinical usefulness of these relatively new techniques for peripheral vascular disorders. In blackfoot disease, blood flux measured by the laser Doppler flowmeter in the affected toe was lower than that in the nonaffected toe. In symptom-free fingers, blood flow was not significantly different between blackfoot disease and arteriosclerosis. However, blood flow in both diseases was lower than that of the control group. Patients who had the same status of thermoregulatory flow and eyeground arteriosclerotic classification underwent a 1-min arterial occlusion of the digits. The postocclusive reactive hyperemia response (PRH) of nailfold capillary loops was evaluated. All parameters for PRH for the cutaneous nutrient microcirculation including resting capillary blood cell velocity (rCBV), peak capillary blood cell velocity (pCBV) and time to pCBV were more significantly disturbed in the blackfoot disease group than in the arteriosclerotic group. On the basis of the results of this study, dynamic capillaroscopy provides a new approach for the early detection of circulatory disturbances resulting from different mechanisms.

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Study of dynamic microcirculatory problems in ‘blackfoot disease’ -emphasizing its differences from arteriosclerosis

Yu

¹

,

Chang

²

,

Chen

³

et al. 1995

View full text Add to dashboard Cite

The cutaneous microcirculation can be divided into thermoregulatory shunt vessels and nutritive skin capillaries. Flux in nonnutritional shunt vessels dominates the signal recorded by the laser Doppler flowmeter. Computerized videophotometric capillaroscopy is a sensitive method for assessing cutaneous nutritive microcirculation. Using patients with blackfoot disease and arteriosclerosis as disease models, we evaluated the sensitivity and clinical usefulness of these relatively new techniques for peripheral vascular disorders. In blackfoot disease, blood flux measured by the laser Doppler flowmeter in the affected toe was lower than that in the nonaffected toe. In symptom-free fingers, blood flow was not significantly different between blackfoot disease and arteriosclerosis. However, blood flow in both diseases was lower than that of the control group. Patients who had the same status of thermoregulatory flow and eyeground arteriosclerotic classification underwent a 1-min arterial occlusion of the digits. The postocclusive reactive hyperemia response (PRH) of nailfold capillary loops was evaluated. All parameters for PRH for the cutaneous nutrient microcirculation including resting capillary blood cell velocity (rCBV), peak capillary blood cell velocity (pCBV) and time to pCBV were more significantly disturbed in the blackfoot disease group than in the arteriosclerotic group. On the basis of the results of this study, dynamic capillaroscopy provides a new approach for the early detection of circulatory disturbances resulting from different mechanisms. Copyright 1995 S. Karger AG, Basel

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Simultaneous Changes in Leg Arterial Pulsatile Blood Flow and Toe Laser-Doppler Perfusion Accompanying Graded Thigh Compression

Mayrovitz

¹

1998

Vascular Surgery

1

0

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Previous findings showed that regional ankle cuff compression and below-knee compression bandaging cause significant decreases in skin blood perfusion distal to the compressed regions. Contrastingly, with compression bandaging, as is commonly used in the treatment of venous ulcers and other conditions, an increase in leg pulsatile blood flow in compressed regions has been reported without corresponding decreases in sub-bandage skin blood perfusion. The explanation for these differential effects is unclear in part because of the fact that foot-to-knee compression bandaging has both direct sub-bandage tissue effects and effects on distal and sub-bandage venous hemodynamics. To help clarify this issue, the present study was done to determine the role of compression-induced changes in venous pressure per se on both skin microvascular and calf pulsatile blood flow. This was done using graded thigh cuff compression up to 50 mm Hg to modify lower extremity venous pressure. During these compressions mid-calf pulsatile blood flow via magnetic resonance flowmetry and toe-skin laser-Doppler blood perfusion

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Effects of Atherosclerosis on the Cutaneous Regional and Microcirculatory Response to Ischemia

Cited by 3 publications

References 13 publications

Study of Dynamic Microcirculatory Problems in 'Blackfoot Disease' - Emphasizing Its Differences from Arteriosclerosis

Study of Dynamic Microcirculatory Problems in 'Blackfoot Disease' - Emphasizing Its Differences from Arteriosclerosis

Study of dynamic microcirculatory problems in ‘blackfoot disease’ -emphasizing its differences from arteriosclerosis

Simultaneous Changes in Leg Arterial Pulsatile Blood Flow and Toe Laser-Doppler Perfusion Accompanying Graded Thigh Compression

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