Effects of atenolol on left ventricular hypertrophy and early left ventricular function in essential hypertension

Allen, John; Kaiser, Pamela; Montenegro, A

doi:10.1016/0002-9149(89)90870-9

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…group was within the range of our intra-observer variability and may in part have been caused by nifedipine, our results may be in agreement with those of Allen et al [27]. Schulman et al [7] did not observe changes in LVM, LVID or LVWT with atenolol, but their patients were > 60 years of age, only 3/21 subjects had LVM index 2 125 g mW2, and the follow-up period was only 6 months.…”

Section: Discussionsupporting

confidence: 92%

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Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year'r treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double‐blind, randomized study

Otterstad

Froeland

Soeyland

et al. 1992

Journal of Internal Medicine

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In a randomized double-blind study to compare the effect of atenolol vs. hydrochlorothiazide and amiloride (Moduretic) on left ventricular dimensions and systolic function, 100 hypertensive men were followed up during 1 year of treatment, 50 subjects being randomized to each drug. Echocardiography was performed at baseline, and after 3 and 12 months of treatment. A significant reduction in left ventricular mass with atenolol was paralleled by a decrease in left ventricular wall thickness and an increase in stroke volume. A similar reduction of left ventricular mass with Moduretic without a change in relative wall thickness and a decrease in stroke volume was observed. Cardiac output decreased in both groups.

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Section: Discussionsupporting

confidence: 92%

“…The reduction in LVM with atenolol is similar to most [1.2,3-51. but not all [27]. previous reports.…”

Section: Discussionmentioning

confidence: 57%

Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year'r treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double‐blind, randomized study

Otterstad

Froeland

Soeyland

et al. 1992

Journal of Internal Medicine

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“…After 30 weeks of monotherapy with atenolol in an open-label trial, LV mass and wall thickness decreased, but these reductions were not statistically significant. 206 The alterations in ventricular structure were associated with an increase in the ratio of ear1y:late diastolic filling, indicating a trend toward improved diastolic function. Systolic function showed no significant changes.…”

Section: P-adrenergic Blockersmentioning

confidence: 98%

Hypertension and Left Ventricular Hypertrophy: Is Drug Therapy Beneficial?

Eselin

Carter

1994

Pharmacotherapy

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Left ventricular hypertrophy (LVH) is a consequence of long-standing hypertension and is considered to be an independent risk factor for cardiovascular morbidity and mortality. Several antihypertensive agents are capable of inducing regression of LVH, but it is not known which class of drugs is most effective. The impact of drug-induced reversal of hypertrophy on ventricular function remains a controversial issue. Furthermore, the long-term clinical benefits of LVH regression have yet to be documented. Controversies also exist regarding the clinical outcomes associated with drug-induced LVH regression.

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Left ventricular filling in the hypertensive patient: Long‐Term course and influence of treatment

Gosse

Jullien

Jarnier

et al. 1999

Clinical Cardiology

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Effects of atenolol on left ventricular hypertrophy and early left ventricular function in essential hypertension

Cited by 6 publications

References 11 publications

Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year'r treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double‐blind, randomized study

Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year'r treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double‐blind, randomized study

Hypertension and Left Ventricular Hypertrophy: Is Drug Therapy Beneficial?

Left ventricular filling in the hypertensive patient: Long‐Term course and influence of treatment

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