Effects of aspartic acid salts (Mg and K) on swimming performance of rats and dogs

Abstract

Five separate experiments were performed to evaluate the effects, if any, of Mg and K salts of aspartic acid on the swimming times of rats and dogs. Experiments 1 and 2 were with rats doing a single swim-to-exhaustion in water maintained at 17 C and 25 C. In experiment 3 dogs performed a single swim-to-exhaustion in 17 C water. During the first three experiments each animal underwent two treatments; a no-treatment control, and an aspartate therapy. Experiment 4 was a long-term single swim-to-exhaustion test. The rats were divided into two groups: one group receiving a placebo and the other group receiving aspartate. Each group swam to exhaustion in 25 C water twice a week for 6 weeks. Experiment 5 was of the same experimental design as experiment 4 with the exception that a double swim-to-exhaustion was used to measure performance. Statistical analysis of the mean swimming times for both rats and dogs in the five experiments showed that average swimming times under control and aspartate therapy were not significantly different. exercise; ergogenic drugs; swimming time to exhaustion endurance criterion Submitted on May 8, 1963

Absence of Effect of Potassium-Magnesium Aspartate on Physiologic Responses to Prolonged Work in Aerobically Trained Men

“…However, the treatlmill performance time of two well-trained men was unaffected. This lack of effect on physiologic responses to work and performance times was also reported by Matoush et al (9) who found that K + Mg Asp administered 30 mm prior to work did not improve swimming performance in rats and dogs and that daily administration for 2 weeks also had no effect on the swimming performance times of rats. In addition, Consolazio et al 4 In previous studies (1,7,10,18), a control trial devoid of placebo and K+Mg Asp tablets was not conducted while the sequence of the trials was first, placebo and second, K+Mg Asp.…”

“…Enhanced exercise performance has been reported after acute administration of potassium (K) and magnesium (Mg) aspartate (Asp) in rats (15) and man (1,7,12,18) and after prolonged, daily consumption in man (10). However, other investigations in rats and dogs (9) and man (4) suggest that the ergogenic benefits of acute and prolonged administration of K ÷ Mg Asp are nonexistent.…”

The Effects of Oral Administration of Salts of Aspartic Acid on the Metabolic Response to Prolonged Exhausting Exercise in Man

“…This is in contrast to earlier reports, which found that treatment with salts of aspartic acid was effective in improving the work tolerance of rats (14,21) and men (1). Neither Matoush et al (15) in a study using rats and dogs, nor Consolazio et al 6and 1-lagan et al (8) studying humans, found any effect of aspartate administration on physical performance, in agreement with the present results. it should be noted, however, that Consolazio et al (6) and Hagan et al (8) made no measurement of work time to exhaustion.…”

A reconsideration of psychological precursors of sudden death in infrahuman animals.

“…The diameter of the cylinder, on the other hand, needs to be narrow enough to prevent the rat from floating at the periphery of the cylinder, away from the jet. Regarding water depth in the cylinder, we found that at the shallower depths (30-38 cm) the rats were able to get support from their tails to help keep their nostrils above water (see Figure 2), a finding reported in other accounts of rodent swimming tests (e.g., Matoush, Consolazio, Nelson, Isaac, & Torres, 1964). In addition to tail-sitting, we saw a type of bobbing in which the rat sinks to the bottom, rests, and then springs from the bottom to the surface-also described elsewhere (e.g., Baker & Horvath, 1964a, 1964b.…”