Effects of Ashwagandha (Roots of <i>Withania somnifera</i>) on Neurodegenerative Diseases

Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera DUNAL) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors

“…Adaptogens refer to substances that increase the "state of non-specific resistance to stressors of the everyday life," have normalizing action and are relati used in the Ayurvedic medicinal system to treat general conditions like debility, stress, nervous exhaustion, insomnia, loss of memory, and to enhance cognitive function (Sivarajan and Balachandran, 1994;Warrier et al, 1996;Usmanghani et al, 1997;Kuboyama et al, 2014). Double-blind, placebo-controlled and randomized clinical studies have shown that WS has beneficial precognitive effects on bipolar disorder (Chengappa et al, 2013), and reduction of stress and anxiety measured by the Beck Anxiety Inventory that support its traditional use (Cooley et al, 2009).…”

Anticancer activities ofWithania somnifera: Current research, formulations, and future perspectives

“…Methanolic extract of W. somnifera contains withanolide A, withanoside IV, and withanoside VI. These are reported to induce outgrowths in neurites in neuroblastoma disease (Kuboyama et al, 2014).…”

Management of Alzheimers Disease: Role of Existing Therapies, Traditional Medicines and New Treatment Targets

“…Various Ayurvedic herbs like Amla (Phyllanthus emblica), Guduchi (Tinospora cordifolia), Shankhapushpi (Convolvulus pluricaulis), Ashwagandha (Withania somnifera), Tulsi (Ocimum sanctum), Mandukaparni (Centella asiatica) and Haritaki (Terminalia chebula) have been used in the treatment of memory disorders effectively [105][106][107][108][109][110][111] . Nishteswar et al has reviewed the use of these indigenous herbs in the management of AD and highlighted the potential of these herbs [105] .…”