Effects of Ascaris suum Extract and Sulfamethoxazole on Allergic Airway Inflammation

Cho, Eunsang; Park, Bae‐Keun; Son, Hwa–Young

doi:10.4062/biomolther.2011.19.4.466

Cited by 1 publication

(2 citation statements)

References 27 publications

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“…ConA causes a massive increase of activated T cells in the hepatic parenchyma, leading to the secretion of pro‐inflammatory cytokines (IL‐2, IL‐4, IL‐6, TNF‐α, IFN‐γ) and extensive hepatocyte necrosis 1,3 . The anti‐inflammatory and immunosuppressive effect of adult Ascaris suum worms (ASC) has been demonstrated in experimental models for allergic asthma, rheumatoid arthritis and autoimmune hepatitis 4‐6 . Its suppressive capacity is due to high molecular weight components 7 .…”

Section: Introductionmentioning

confidence: 99%

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Extract from Ascaris suum and N‐acetyl‐L‐cysteine induces an immunosuppressant effect in model of autoimmune hepatitis

Silva

Souto

et al. 2021

Parasite Immunology

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Background Extract of adult Ascaris suum (ASC) worms attenuated the liver damage in experimental autoimmune hepatitis (EAH) with induction of Th2 immune response, but fibrosis occurred. N‐acetyl‐L‐cysteine (NAC) has protective effects against liver fibrosis. Objectives Evaluate the association ASC + NAC on the T‐ and B‐cell activation, inflammation and fibrogenic markers in the liver in EAH. Methods Experimental autoimmune hepatitis was induced intravenously with concanavalin A in BALB/c mice. EAH + ASC+NAC group received NAC and ASC; EAH + ASC group received ASC; EAH group received PBS. Doubly labelled CD4+ T (CD28, CTLA‐4, CD40L or IL‐10) and CD45R+ B lymphocytes (IL‐10) and CD4+CD25+FoxP3+ cells were evaluated, along with gene expression of Col1a1, α‐SMA, Fizz1, Arg1 and PPAR‐γ and histomorphometry. Results Experimental autoimmune hepatitis group showed high frequency of CD28+ and CD40L+ T lymphocytes, but not the EAH + ASC group. In relation to EAH group, the Fizz1 expression was lower in both groups treated, but Arg1 expression was lower in only EAH + ASC+NAC group. In the EAH + ASC+NAC group, there were higher frequencies of CD4+IL‐10+ and CD4+CD25+FoxP3+ cells, but not CD45R+IL‐10+, along with mitigated inflammation and collagen production. Conclusions Ascaris suum favoured immunosuppression in EAH limiting the T cells activation. However, association ASC and NAC was necessary for attenuating the inflammatory process and collagen production.

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Section: Introductionmentioning

confidence: 99%

“…arthritis and autoimmune hepatitis. [4][5][6] Its suppressive capacity is due to high molecular weight components. 7 We observed that in EAH, ASC attenuates the liver damage with induction of a Th2 immune, through increasing the levels of IL-4, IL-10 and IL-13 in the spleen; however, an increase in liver fibrosis was also observed in the animals.…”

mentioning

confidence: 99%

Extract from Ascaris suum and N‐acetyl‐L‐cysteine induces an immunosuppressant effect in model of autoimmune hepatitis

Silva

Souto

et al. 2021

Parasite Immunology

View full text Add to dashboard Cite

show abstract

Effects of Ascaris suum Extract and Sulfamethoxazole on Allergic Airway Inflammation

Cited by 1 publication

References 27 publications

Extract from Ascaris suum and N‐acetyl‐L‐cysteine induces an immunosuppressant effect in model of autoimmune hepatitis

Extract from Ascaris suum and N‐acetyl‐L‐cysteine induces an immunosuppressant effect in model of autoimmune hepatitis

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