Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

Shahinfar, Hossein; Bazshahi, Elham; Amini, Mohammad Reza; Payandeh, Nastaran; Pourreza, Sanaz; Noruzi, Zahra; Shab‐Bidar, Sakineh

doi:10.1002/ptr.7247

Cited by 7 publications

(4 citation statements)

References 66 publications

(161 reference statements)

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“…In our study, there is no significant effect of artichoke on HDL-C level. This finding is in agreement with work in (Shahinfar et al, 2021) which demonstrated, that no significant effect of artichoke on HDL-C level, and also with study in (Sahebkar et al, 2018) which reported that no significant alteration in plasma High Density Lipoprotein-Cholesterol by artichoke.…”

Section: Discussionsupporting

confidence: 93%

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Adawi¹,

PEKER²

2022

AJRSP

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Objective: Dietary plants have gained great attention, because they can play important role in enhancement of health and wellbeing. The purpose of our study was to look into the effect of artichoke extract on hypercholesterolemic status of bile duct ligation rat model. Materials and Methods: In this study we used 21 Wistar albino rats. They randomly assigned into three groups; Group 1 (control group) underwent laparotomy alone and the common bile duct was only exposed and no drug was applied. Group 2 (BDL group) was subjected only to bile duct ligation (BDL) and no drug was applied. Group 3 (BDL +Ac) received a daily dose of 1.5 g/kg/per os of artichoke extract starting 24 hours after BDL. After 7 days of treatment, the animals were sacrificed, the blood samples were taken and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were analysed. Results: TC decreased in BDL+ Ac group compared to BDL group (44.42±21.19, 61.2±11.3). The LDL-C decreased in BDL+ Ac group compared to BDL group (28,5±10,05, 38,4±3,91) with a statistical significance (p<0,05). HDL decreased in BDL group and in BDL+ Ac group compared to the control group; however, it indicated no statistically significant difference (p>0,05). Conclusion: In this research, artichoke extract application may improve hypercholesterolemic status of bile duct ligation. Further studies with larger volume are required to support our promising results.

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Section: Discussionsupporting

confidence: 93%

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Adawi¹,

PEKER²

2022

AJRSP

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“…According to existing literature, the consumption of artichoke leaf extract (ALE) may lead to a reduction in cholesterol levels among individuals with hypercholesterolemia (6). Furthermore, it has been observed that ALE exhibits a reduction in the generation of reactive oxygen species, as well as the oxidation of low-density lipoproteins (LDL) and lipid peroxidation (7).This study 's primary purpose is to evaluate the therapeutic efficacy of artichoke in modulating biochemical oxidants, antioxidant enzymes, and liver biomarkers in adult male albino rats with nonalcoholic fatty liver disease.…”

Section: Introductionmentioning

confidence: 99%

Role of Artichoke Leaf Extract as Antioxidant in Nonalcoholic Fatty Liver Disease of Adult Male Albino Rats

Zoair,

Abdelhay,

El-Said

2023

Benha Medical Journal

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Background:The artichoke plant, scientifically known as Cynara scolymus, is often planted in Mediterranean regions. It has a notable abundance of antioxidants. This research aims to evaluate the medical capacity of artichoke in modulating biochemical oxidant and antioxidant enzymes, as well as liver biomarkers, in adult male albino rats with nonalcoholic fatty liver disease. Methods: The rats were allocated into three distinct cohorts for the purpose of the study: a control group, a group that was provided with a high-fat diet to induce hyperlipidemia, and a group that received treatment with artichoke leaf extract. Following the conclusion of the experimental phase, blood samples were obtained and subjected to analysis to assess the lipid profile, liver enzyme activity, as well as the levels of malondialdehyde (MDA) and glutathione peroxidase (GSH-PX). Additionally, liver specimens had been subjected to examination using a light microscope. Results: Artichoke extract improved blood serum lipids in rats with NAFLD. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), very lowdensity lipoprotein (VLDL), and TC/HDL and LDL/HDL ratios decreased significantly. HDL values also rose. The treatment with artichoke extract to rats with NAFLD significantly reduced liver enzyme levels. In the group with non-alcoholic fatty liver disease (NAFLD), artichoke extract restored GSH and MDA levels to normal levels. Conclusions: The use of artichoke in rat models of non-alcoholic fatty liver disease (NAFLD) had a relation to diminished indicators of oxidative stress.

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“…Dyslipidemia, clinically featured by abnormally high blood lipid concentrations, is frequently associated with atherosclerotic heart disease, including coronary heart disease, stroke, and peripheral artery disease [1][2][3]. Evidence from 1127 population-based studies measuring blood lipids in 102.6 million people aged 18 years and older showed that although there was little change in total cholesterol, or non-HDL lipoprotein cholesterol in the global population from 1980 to 2018, the net effect in low-and middle-income countries, particularly in East and Southeast Asia, increased but declined in high-income western countries, particularly in Northwest Europe, and in Central and Eastern Europe.…”

Section: Introductionmentioning

confidence: 99%

The Effect of MUFA-Rich Food on Lipid Profile: A Meta-Analysis of Randomized and Controlled-Feeding Trials

Cao

Xia

Zhou

et al. 2022

Foods

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Since the effects of mono-unsaturated fatty acids (MUFA) on lipid profile are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of MUFA-rich food on lipid profiles. The study was designed, conducted, and reported according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. A systematic and comprehensive search was performed in several databases from inception up to 30 January 2022. The results showed that the intake of edible oil-derived MUFA (EDM) could increase the blood HDL-C level (mean difference = 0.08; 95%CI: −0.01, 0.17, p = 0.03), but did not affect the level of TC, TG, or LDL-C. Moreover, the consumption of other food-derived MUFA (ODM) significantly decreased TG concentration (mean difference = −0.35; 95%CI: −0.61, −0.09, p = 0.01)), but did not affect the level of TC, LDL-C, or HDL-C. Findings from this study suggest that MUFA-rich food might be beneficial to modulate the blood lipid profile.

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Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

Cited by 7 publications

References 66 publications

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Effect of Artichoke Extract on Hypercholesterolemic Status of Bile Duct Ligation Rat Model

Role of Artichoke Leaf Extract as Antioxidant in Nonalcoholic Fatty Liver Disease of Adult Male Albino Rats

The Effect of MUFA-Rich Food on Lipid Profile: A Meta-Analysis of Randomized and Controlled-Feeding Trials

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