Effects of arsenic exposure during the pre- and postnatal development on the puberty of female offspring

Dávila-Esqueda, Ma. Eugenia; Jiménez-Capdeville, M E; Delgado, Juan Manuel; Cruz, Esperanza de la; Aradillas‐García, Celia; Jiménez-Suárez, Verónica; Escobedo, Reynaldo Falcón; Llerenas, Joel Rodríguez

doi:10.1016/j.etp.2010.06.001

Cited by 32 publications

(9 citation statements)

References 21 publications

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“…The VO day and occurrence of the first estrus are markers of this event (Guyton & Hall, , 1996). In the present work, both parameters were delayed in females after prenatal arsenic exposure corroborating the findings of Dávila-Esqueda et al (2012) in female rats exposed to 3 ppm sodium arsenite in drinking water from gestation to 4 months of age. Delayed puberty usually occurs due to reduced estradiol levels resulting from either hypothalamic and/or pituitary dysfunction or from damage in the ovary (Pine, Hiney, Lee, & Dees, 2008).…”

Section: Discussionsupporting

confidence: 91%

“…However, no differences were observed in serum levels of estradiol and progesterone in these females at PND 85. Dávila-Esqueda et al (2012) also showed changes in the frequency of estrous phases in female rats exposed to 3 ppm sodium arsenite from gestation to 4 months of age, without alteration in estradiol and progesterone levels after PND 30. Thus, it is possible that changes in the HPG axis occurred only during the fetal programming in females from the sodium arsenite group, compromising their puberty onset and estrous cycle, but they were re-established during adulthood maintaining the normal serum levels of progesterone and estradiol.…”

Section: Discussionmentioning

confidence: 82%

“…Kozul-Horvath, Zandbergen, Jackson, Enelow and Hamilton (2012) also showed low birth weight and weight gain of female mice exposed to 10 ppb arsenic in drinking water during gestation and lactation. Moreover, recent studies have demonstrated that arsenic exposure has affected the time of sexual maturation in female offspring (Dávila-Esqueda et al, 2012;Li et al, 2018;Reilly et al, 2014;Rodriguez et al, 2016). Delayed puberty was reported in female rats exposed to 3 ppm sodium arsenite in drinking water from gestation to 4 months of age (Dávila-Esqueda et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Reproductive disorders in female rats after prenatal exposure to sodium arsenite

Souza

Ervilha

Coimbra

et al. 2019

J of Applied Toxicology

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Arsenic is a metalloid widely found in the environment in organic and inorganic forms. Exposure to inorganic arsenic forms via drinking water has been associated with an increased incidence of negative health effects, including reproductive disorders and dysfunction of the endocrine system. However, the impact of arsenic exposure on female reproductive development is still unclear. Therefore, in the present study, we evaluated the effects of prenatal exposure to arsenic on the initial sexual development and puberty onset, and in the morphology of the female reproductive organs, estrous cycle regularity and fertility parameters during adulthood. To do that, pregnant female Wistar rats were exposed to 10 mg/L sodium arsenite via drinking water from gestational day (GD) 1 until GD 21 and the female offspring was evaluated in different postnatal days. Our results showed that prenatal arsenic exposure induced a decrease of litter weight and morphological masculinization in females at postnatal day 1. Moreover, these females had a delay in the age of puberty onset and alteration in estrous cycle number and length. During adulthood, females from the sodium arsenite group showed an increase in endometrium, myometrium and perimetrium areas, and an imbalance in uterine antioxidant enzyme activity. These animals also presented an increase in post‐implantation loss and reabsorption number, leading to reduced viable fetus number. In conclusion, prenatal arsenic exposure in rats was able to promote female masculinization, alter sexual development and impair reproductive performance.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Reproductive disorders in female rats after prenatal exposure to sodium arsenite

Souza

Ervilha

Coimbra

et al. 2019

J of Applied Toxicology

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“…In animals, arsenic induces the spermatotoxicity (Pant, Murthy, & Srivastava, ; Waalkes, Ward, Liu, & Diwan, ) by reducing the weight of testes and accessory sex organs as well as the synthesis of male reproductive hormone especially testosterone (Sarkar, Chaudhari, Chattopadhyay, & Biswas, ). Some authors also reported that arsenic may induce gonad dysfunction through declined testosterone synthesis, apoptosis and necrosis (Davila‐Esqueda et al., ; Khan, Telangb, & Malik, ; Shen et al., ). Many studies have reported that arsenic accumulates in testes, epididymis, seminal vesicle and prostate glands (Danielsson, Dencker, Lindgren, & Tjälve, ; Pant, Kumar, Murthy, & Srivastava, ).…”

Section: Introductionmentioning

confidence: 99%

Review on arsenic-induced toxicity in male reproductive system and its amelioration

2017

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Arsenic is an environmental toxicant which causes mutagenic, teratogenic and carcinogenic defects. It is used as herbicide, fungicide and rodenticide and results in contamination of air, soil and water. Arsenic is also produced through burning of coal industries. The sludge of factories contaminates the fodder and drinking source of water of human and livestock. Arsenic binds thiol groups in tissue proteins and impairs the function of the proteins. This metal affects the mitochondrial enzymes and interrupts the production of energy. Oxidative stress and the generation of reactive oxygen species could also be a consequence of arsenic exposure. High arsenic level may suppress the sensitivity of gonadotroph cells to GnRH as well as gonadotropin secretion by elevating plasma levels of glucocorticoids. These ultimately lead to the development of gonad toxicity in animals and cause the reduction in sperm number, sperm viability and motility. Massive degeneration of germ cells and alterations in the level of LH, FSH and testosterone are also reported. The objective of this review was to find out the effects of arsenic-induced toxicity on male reproductive system in animals and its amelioration.

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“…In males, compromised testosterone production, apoptosis and necrosis seem accountable for the arsenic‐induced gonadal dysfunction (Davila‐Esqueda et al, 2012; Shen et al, 2013). Epidemiologic studies demonstrated that arsenic exposure might deteriorate sperm quality, cause erectile dysfunction and induce infertility (Hsieh et al, 2008; Meeker et al, 2010; Nie, Pei, Han, Xu, & Mu, 2006).…”

Section: Introductionmentioning

confidence: 99%

Casein‐ and pea‐enriched high‐protein diet can take care of the reprotoxic effects of arsenic in male rats

Biswas

Mukhopadhyay

2020

Andrologia

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Arsenic toxicity is a significant health problem featured with several incidents of male reproductive dysfunctions. We studied the protective effects of a casein‐ and pea‐enriched formulated high‐protein diet (FHPD) on arsenic‐mediated testicular dysfunctions in rats. Adult male rats sustained on either a benchmark diet (n = 8) or an isocaloric FHPD (n = 8) were gavaged with arsenic trioxide (3mg/kg body wt/rat/day) for 30 consecutive days. A vehicle‐fed group (n = 8) maintained on the standard diet served as control. The arsenic‐treated group continued on the standard diet had a significantly reduced testicular and accessory sex organs weights. They exhibited decreased count, motility, viability and disrupted plasma membrane integrity of caudal spermatozoa with a higher incidence of gross morphological anomalies and DNA damage. Attenuated steroidogenic enzyme activities and low serum testosterone level vouched for a compromised state of testicular steroidogenesis. An increased testicular malondialdehyde and protein carbonyl contents coupled with impaired activities of antioxidant enzymes and free radical scavengers mirrored a situation of exacerbated testicular oxidative imbalance and disrupted redox homeostasis. FHPD, by and large, countermanded testicular steroidogenesis and antioxidant defence system and revoked the ill effects of arsenic. We conclude that specific protein‐enriched diet may serve as prospective weaponry in encountering the arsenic‐threatened testicular functions.

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Effects of arsenic exposure during the pre- and postnatal development on the puberty of female offspring

Cited by 32 publications

References 21 publications

Reproductive disorders in female rats after prenatal exposure to sodium arsenite

Reproductive disorders in female rats after prenatal exposure to sodium arsenite

Review on arsenic-induced toxicity in male reproductive system and its amelioration

Casein‐ and pea‐enriched high‐protein diet can take care of the reprotoxic effects of arsenic in male rats

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